Sptbn1 (spectrin beta, non-erythrocytic 1) - Rat Genome Database

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Gene: Sptbn1 (spectrin beta, non-erythrocytic 1) Heterocephalus glaber
Analyze
Symbol: Sptbn1
Name: spectrin beta, non-erythrocytic 1
RGD ID: 18918487
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); GTPase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); Golgi to plasma membrane protein transport (ortholog); membrane assembly (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Beckwith-Wiedemann syndrome (ortholog); Bone Fractures (ortholog); DEVELOPMENTAL DELAY, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: spectrin beta chain, non-erythrocytic 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248336,947,273 - 7,089,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248336,947,611 - 7,144,688 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sptbn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248336,947,273 - 7,089,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248336,947,611 - 7,144,688 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPTBN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38254,456,327 - 54,671,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl254,456,327 - 54,671,446 (+)EnsemblGRCh38hg38GRCh38
GRCh37254,683,464 - 54,898,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36254,536,958 - 54,752,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34254,697,181 - 54,799,245NCBI
Celera254,523,740 - 54,739,107 (+)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef254,485,674 - 54,631,223 (+)NCBIHuRef
CHM1_1254,613,602 - 54,828,713 (+)NCBICHM1_1
T2T-CHM13v2.0254,450,519 - 54,665,452 (+)NCBIT2T-CHM13v2.0
Sptbn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,049,395 - 30,218,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,049,395 - 30,218,175 (-)EnsemblGRCm39 Ensembl
GRCm381130,099,395 - 30,268,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,099,395 - 30,268,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371129,999,395 - 30,119,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,000,434 - 30,119,772 (-)NCBIMGSCv36mm8
Celera1132,468,358 - 32,593,393 (-)NCBICelera
Cytogenetic Map11A3.3NCBI
cM Map1117.44NCBI
Sptbn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,042,629 - 108,217,884 (-)NCBIGRCr8
mRatBN7.214103,841,713 - 104,016,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14103,842,684 - 104,008,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14108,170,773 - 108,336,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014109,405,426 - 109,571,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014105,877,837 - 106,043,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014114,517,839 - 114,700,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14114,518,816 - 114,692,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014114,188,053 - 114,356,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414111,076,741 - 111,246,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114111,255,392 - 111,259,578 (+)NCBI
Celera14102,708,226 - 102,873,561 (-)NCBICelera
Cytogenetic Map14q22NCBI
Sptbn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544120,248,578 - 20,378,038 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544120,248,578 - 20,378,038 (+)NCBIChiLan1.0ChiLan1.0
SPTBN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21271,664,972 - 71,804,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A71,668,924 - 71,876,651 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A54,608,711 - 54,816,083 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A55,822,415 - 55,961,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A55,822,415 - 55,961,925 (+)Ensemblpanpan1.1panPan2
SPTBN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11055,429,989 - 55,571,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1055,429,940 - 55,571,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1055,325,541 - 55,524,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01056,373,040 - 56,571,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1056,374,468 - 56,571,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11056,064,719 - 56,261,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01056,353,568 - 56,552,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,700,647 - 56,842,710 (+)NCBIUU_Cfam_GSD_1.0
Sptbn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629227,462,919 - 27,650,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491956,986 - 1,108,640 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936491920,830 - 1,108,374 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTBN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl386,585,054 - 86,784,149 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1386,585,225 - 86,784,316 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPTBN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11452,266,197 - 52,487,111 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1452,262,416 - 52,487,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604559,248,465 - 59,459,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000027186   ⟹   ENSHGLP00000026947
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248336,947,273 - 7,089,924 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000027187   ⟹   ENSHGLP00000026948
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248336,956,589 - 7,059,518 (-)Ensembl
RefSeq Acc Id: XM_004867283   ⟹   XP_004867340
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248336,948,695 - 7,144,688 (-)NCBI
RefSeq Acc Id: XM_004867284   ⟹   XP_004867341
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248336,956,579 - 7,059,144 (-)NCBI
RefSeq Acc Id: XM_013066431   ⟹   XP_012921885
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248336,947,611 - 7,059,530 (-)NCBI
RefSeq Acc Id: XM_021246281   ⟹   XP_021101940
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248336,947,611 - 7,089,877 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004867340 (Get FASTA)   NCBI Sequence Viewer  
  XP_004867341 (Get FASTA)   NCBI Sequence Viewer  
  XP_012921885 (Get FASTA)   NCBI Sequence Viewer  
  XP_021101940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026947
  ENSHGLP00000026948
GenBank Protein JAO01763 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021101940   ⟸   XM_021246281
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JBS1 (UniProtKB/TrEMBL),   G5B8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012921885   ⟸   XM_013066431
- Peptide Label: isoform X2
- UniProtKB: G5B8V8 (UniProtKB/TrEMBL),   A0AAX6QMS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867340   ⟸   XM_004867283
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JBS1 (UniProtKB/TrEMBL),   G5B8V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867341   ⟸   XM_004867284
- Peptide Label: isoform X3
- UniProtKB: G5B8V8 (UniProtKB/TrEMBL),   A0AAX6Q6W6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026947   ⟸   ENSHGLT00000027186
Ensembl Acc Id: ENSHGLP00000026948   ⟸   ENSHGLT00000027187


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000027186 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00000027187 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  PH_dom-spectrin-type UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_bsu UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report hgl:101714374 UniProtKB/TrEMBL
NCBI Gene Sptbn1 ENTREZGENE
PANTHER SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PIRSF Spectrin_beta_subunit UniProtKB/TrEMBL
PRINTS SPECTRINPH UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A0P6JBS1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q6W6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QMS4 ENTREZGENE, UniProtKB/TrEMBL
  G5B8V8 ENTREZGENE, UniProtKB/TrEMBL