Spns2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Spns2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate) Heterocephalus glaber
Analyze
Symbol: Spns2
Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate (Ensembl:sphingolipid transporter 2)
RGD ID: 18914920
Description: ENCODES a protein that exhibits sphingolipid transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN B cell homeostasis (ortholog); bone development (ortholog); lymph node development (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 115 (ortholog); genetic disease (ortholog); Hearing Loss (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein spinster homolog 2; sphingolipid transporter 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,066,142 - 7,102,501 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247867,065,992 - 7,103,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spns2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,066,142 - 7,102,501 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247867,065,992 - 7,103,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPNS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,498,881 - 4,539,035 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,498,881 - 4,539,035 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,402,176 - 4,442,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,348,878 - 4,389,977 (+)NCBINCBI36Build 36hg18NCBI36
Celera174,414,308 - 4,455,423 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,291,496 - 4,332,622 (+)NCBIHuRef
CHM1_1174,410,907 - 4,452,037 (+)NCBICHM1_1
T2T-CHM13v2.0174,388,772 - 4,428,933 (+)NCBIT2T-CHM13v2.0
Spns2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,342,464 - 72,380,797 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,342,464 - 72,380,730 (-)EnsemblGRCm39 Ensembl
GRCm381172,451,638 - 72,489,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,451,638 - 72,489,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,265,140 - 72,303,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1179,972,105 - 80,010,084 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1144.31NCBI
Spns2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,565,909 - 57,604,546 (-)NCBIGRCr8
mRatBN7.21057,067,348 - 57,105,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,066,897 - 57,105,957 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1061,730,551 - 61,769,146 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,219,031 - 61,257,622 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,718,113 - 56,756,704 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,010,428 - 59,049,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,010,428 - 59,049,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01058,749,467 - 58,788,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,335,327 - 59,374,485 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1056,193,499 - 56,232,580 (-)NCBICelera
Cytogenetic Map10q24NCBI
Spns2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,406,666 - 12,441,490 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,405,172 - 12,441,490 (-)NCBIChiLan1.0ChiLan1.0
SPNS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,116,084 - 12,155,667 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,084,500 - 14,124,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,554,524 - 4,593,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,547,588 - 4,586,562 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,547,597 - 4,584,493 (+)Ensemblpanpan1.1panPan2
SPNS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1530,494,355 - 30,527,669 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha530,698,147 - 30,724,161 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0530,602,774 - 30,628,798 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl530,565,374 - 30,628,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,568,887 - 30,593,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0530,527,403 - 30,553,400 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,700,824 - 30,726,847 (+)NCBIUU_Cfam_GSD_1.0
Spns2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560254,807,734 - 54,842,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366771,058,595 - 1,093,147 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366771,058,601 - 1,093,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPNS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,454,063 - 50,491,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,454,051 - 50,491,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,453,862 - 52,489,002 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPNS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,978,262 - 4,019,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,978,845 - 4,022,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605917,641,634 - 17,682,817 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000020400   ⟹   ENSHGLP00000020199
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247867,066,142 - 7,102,501 (+)Ensembl
RefSeq Acc Id: XM_004857246   ⟹   XP_004857303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,065,995 - 7,102,615 (+)NCBI
RefSeq Acc Id: XM_013076813   ⟹   XP_012932267
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,067,708 - 7,103,944 (+)NCBI
RefSeq Acc Id: XM_021238449   ⟹   XP_021094108
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,066,060 - 7,103,944 (+)NCBI
RefSeq Acc Id: XM_021238450   ⟹   XP_021094109
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,065,992 - 7,103,944 (+)NCBI
RefSeq Acc Id: XM_021238451   ⟹   XP_021094110
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,066,060 - 7,103,944 (+)NCBI
RefSeq Acc Id: XM_021238452   ⟹   XP_021094111
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,066,058 - 7,101,840 (+)NCBI
RefSeq Acc Id: XM_021238453   ⟹   XP_021094112
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247867,066,060 - 7,102,615 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021094109   ⟸   XM_021238450
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004857303   ⟸   XM_004857246
- Peptide Label: isoform X7
- UniProtKB: G5B922 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094111   ⟸   XM_021238452
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021094108   ⟸   XM_021238449
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021094110   ⟸   XM_021238451
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021094112   ⟸   XM_021238453
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012932267   ⟸   XM_013076813
- Peptide Label: isoform X6
RefSeq Acc Id: ENSHGLP00000020199   ⟸   ENSHGLT00000020400


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014461 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020400 ENTREZGENE
Gene3D-CATH MFS general substrate transporter like domains UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_spinster-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
NCBI Gene Spns2 ENTREZGENE
PANTHER PROTEIN SPINSTER HOMOLOG 2 UniProtKB/TrEMBL
  SPINSTER UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL
UniProt G5B922 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-25 Spns2  SPNS lysolipid transporter 2, sphingosine-1-phosphate  Spns2  sphingolipid transporter 2  Symbol and/or name change 5135510 APPROVED