Aplp1 (amyloid beta precursor like protein 1) - Rat Genome Database

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Gene: Aplp1 (amyloid beta precursor like protein 1) Heterocephalus glaber
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Symbol: Aplp1
Name: amyloid beta precursor like protein 1
RGD ID: 18908186
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to norepinephrine stimulus (ortholog); cytosolic mRNA polyadenylation (ortholog); extracellular matrix organization (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); hereditary spastic paraplegia 75 (ortholog); FOUND IN nucleoplasm (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amyloid beta (A4) precursor-like protein 1; amyloid-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,148,522 - 10,167,543 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,148,575 - 10,158,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aplp1Naked Mole-RatBrugada syndrome 5  ISOAPLP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Brugada syndrome 5ClinVarPMID:28492532
Aplp1Naked Mole-Rathereditary spastic paraplegia 75  ISOAPLP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 75ClinVarPMID:28492532


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aplp1Naked Mole-Ratendomembrane system located_inIEAARBA:ARBA00028953150520179 UniProtGO_REF:0000117
Aplp1Naked Mole-RatGolgi apparatus located_inIEAPANTHER:PTN000559861 and PANTHER:PTN000559862150520179 TreeGrafterGO_REF:0000118
Aplp1Naked Mole-Ratmembrane located_inIEAInterPro:IPR008155150520179 InterProGO_REF:0000002
Aplp1Naked Mole-Ratmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Aplp1Naked Mole-Ratmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
Aplp1Naked Mole-Ratnucleoplasm located_inISOAPLP1 (Homo sapiens)9068941 HPAGO_REF:0000052
Aplp1Naked Mole-Ratperinuclear region of cytoplasm located_inISOAPLP1 (Homo sapiens)9068941 PMID:16531006BHF-UCLPMID:16531006
Aplp1Naked Mole-Ratplasma membrane located_inIEAPANTHER:PTN000559861 and PANTHER:PTN000559862150520179 TreeGrafterGO_REF:0000118

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Aplp1Naked Mole-Ratalpha-2A adrenergic receptor binding enablesIEAPANTHER:PTN000559861 and PANTHER:PTN000559862150520179 TreeGrafterGO_REF:0000118
Aplp1Naked Mole-Ratalpha-2B adrenergic receptor binding enablesIEAPANTHER:PTN000559861 and PANTHER:PTN000559862150520179 TreeGrafterGO_REF:0000118
Aplp1Naked Mole-Ratalpha-2C adrenergic receptor binding enablesIEAPANTHER:PTN000559861 and PANTHER:PTN000559862150520179 TreeGrafterGO_REF:0000118
Aplp1Naked Mole-Ratheparin binding enablesIEAInterPro:IPR015849 and InterPro:IPR036454150520179 InterProGO_REF:0000002
Aplp1Naked Mole-Ratheparin binding enablesIEAUniRule:UR000976770150520179 UniProtGO_REF:0000104
Aplp1Naked Mole-Ratidentical protein binding enablesISOUniProtKB:P516939068941 PMID:16193067 and PMID:21930949IntActPMID:16193067 and PMID:21930949
Aplp1Naked Mole-Ratprotein binding enablesISOPR:Q9QXJ19068941 PMID:8894693MGIPMID:8894693
Aplp1Naked Mole-Ratprotein binding enablesISOPR:P701669068941 PMID:16314516MGIPMID:16314516
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:Q8C1429068941 PMID:17727637BHF-UCLPMID:17727637
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:Q9UBQ0-29068941 PMID:32814053IntActPMID:32814053
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:P170289068941 PMID:16169070IntActPMID:16169070
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:Q930749068941 PMID:21293490IntActPMID:21293490
Aplp1Naked Mole-Ratprotein binding  ISOApbb1 (Rattus norvegicus)9068941 RGDPMID:9461550 and REF_RGD_ID:634556
Aplp1Naked Mole-Ratprotein binding  ISOApbb3 (Rattus norvegicus)9068941 RGDPMID:9461550 and REF_RGD_ID:634556
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:P973189068941 PMID:10460257 and PMID:12826668IntActPMID:10460257 and PMID:12826668
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:P120239068941 PMID:16193067 and PMID:17934213IntActPMID:16193067 and PMID:17934213
Aplp1Naked Mole-Ratprotein binding enablesISOUniProtKB:P05067-4 and UniProtKB:Q064819068941 PMID:16193067IntActPMID:16193067
Aplp1Naked Mole-Rattransition metal ion binding enablesIEAInterPro:IPR011178 and InterPro:IPR036669150520179 InterProGO_REF:0000002
1 to 18 of 18 rows

PMID:22301074   PMID:30032202  



Aplp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,148,522 - 10,167,543 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479410,148,575 - 10,158,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
APLP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,868,574 - 35,879,792 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,867,899 - 35,879,803 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,359,476 - 36,370,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,051,241 - 41,062,539 (+)NCBINCBI36Build 36hg18NCBI36
Build 341941,051,309 - 41,062,530NCBI
Celera1933,073,585 - 33,084,883 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,864,721 - 32,875,938 (+)NCBIHuRef
CHM1_11936,360,683 - 36,371,980 (+)NCBICHM1_1
T2T-CHM13v2.01938,414,328 - 38,425,546 (+)NCBIT2T-CHM13v2.0
Aplp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,134,405 - 30,144,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,134,407 - 30,144,960 (-)EnsemblGRCm39 Ensembl
GRCm38730,434,980 - 30,445,582 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,434,982 - 30,445,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,220,001 - 31,230,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,143,742 - 30,154,321 (-)NCBIMGSCv36mm8
Celera725,026,598 - 25,037,193 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.32NCBI
Aplp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,824,330 - 94,834,705 (-)NCBIGRCr8
mRatBN7.2185,696,880 - 85,707,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,696,882 - 85,707,155 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,113,388 - 91,123,714 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,579,915 - 99,590,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,871,656 - 92,881,982 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,897,525 - 88,908,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,897,532 - 88,908,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,053,390 - 90,063,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,390,217 - 85,401,952 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera180,069,348 - 80,079,276 (-)NCBICelera
Cytogenetic Map1q21NCBI
Aplp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,694,591 - 2,703,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,694,286 - 2,703,658 (-)NCBIChiLan1.0ChiLan1.0
APLP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,867,959 - 41,879,251 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,852,723 - 43,864,012 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,786,362 - 32,797,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,534,776 - 41,545,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,534,569 - 41,545,906 (+)Ensemblpanpan1.1panPan2
APLP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,774,392 - 116,783,101 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,728,529 - 116,783,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,179,958 - 116,188,648 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,377,571 - 117,386,261 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,377,575 - 117,386,219 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,941,125 - 116,949,814 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,564,643 - 116,573,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,620,429 - 117,629,122 (-)NCBIUU_Cfam_GSD_1.0
Aplp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,161,610 - 11,170,431 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570474,902 - 484,188 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570475,446 - 484,379 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,285,718 - 45,295,350 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,285,698 - 45,295,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,669,837 - 40,672,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APLP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,780,112 - 30,791,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,780,085 - 30,791,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,572,301 - 8,583,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000024193   ⟹   ENSHGLP00000023975
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479410,148,522 - 10,167,543 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000024194   ⟹   ENSHGLP00000023976
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479410,148,522 - 10,167,543 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000024195   ⟹   ENSHGLP00000023977
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462479410,148,642 - 10,167,135 (+)Ensembl
RefSeq Acc Id: XM_004858949   ⟹   XP_004859006
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,588 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_004858950   ⟹   XP_004859007
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,590 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_013077414   ⟹   XP_012932868
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,581 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_013077415   ⟹   XP_012932869
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,583 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_013077416   ⟹   XP_012932870
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,578 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_013077417   ⟹   XP_012932871
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,582 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_021239454   ⟹   XP_021095113
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,575 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_021239455   ⟹   XP_021095114
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,579 - 10,158,101 (+)NCBI
RefSeq Acc Id: XM_021239456   ⟹   XP_021095115
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462479410,148,578 - 10,158,101 (+)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: XP_021095113   ⟸   XM_021239454
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RGZ4 (UniProtKB/TrEMBL),   G5BXP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932870   ⟸   XM_013077416
- Peptide Label: isoform X4
- UniProtKB: A0AAX6R2A7 (UniProtKB/TrEMBL),   G5BXP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095115   ⟸   XM_021239456
- Peptide Label: isoform X8
- UniProtKB: A0AAX6RD67 (UniProtKB/TrEMBL),   G5BXP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021095114   ⟸   XM_021239455
- Peptide Label: isoform X5
- UniProtKB: A0AAX6RGM8 (UniProtKB/TrEMBL),   G5BXP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932868   ⟸   XM_013077414
- Peptide Label: isoform X1
- UniProtKB: A0AAX6R416 (UniProtKB/TrEMBL),   G5BXP2 (UniProtKB/TrEMBL)



1 to 40 of 41 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000017091 Ensembl
Gene3D-CATH Amyloid precursor protein, E2 domain UniProtKB/TrEMBL
  Amyloidogenic glycoprotein, copper-binding domain UniProtKB/TrEMBL
  Amyloidogenic glycoprotein, heparin-binding domain UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/TrEMBL
  E2_sf UniProtKB/TrEMBL
NCBI Gene Aplp1 ENTREZGENE
PANTHER ALZHEIMER'S DISEASE BETA-AMYLOID RELATED UniProtKB/TrEMBL
  AMYLOID-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_N UniProtKB/TrEMBL
PRINTS AMYLOIDA4 UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/TrEMBL
  APP_E1 UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_INTRA UniProtKB/TrEMBL
SMART A4_EXTRA UniProtKB/TrEMBL
Superfamily-SCOP A heparin-binding domain UniProtKB/TrEMBL
  Amyloid beta a4 protein copper binding domain (domain 2) UniProtKB/TrEMBL
  CAPPD, an extracellular domain of amyloid beta A4 protein UniProtKB/TrEMBL
UniProt A0AAX6PSS7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PU42 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R2A7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R416 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R569 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R5I0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RD67 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RGM8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RGZ4 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows