Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Pilocarpine results in decreased expression of APLP1 mRNA | CTD | PMID:19448684 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of APLP1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APLP1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of APLP1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of APLP1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of APLP1 mRNA | CTD | PMID:22467019 | 17beta-estradiol | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of APLP1 mRNA | CTD | PMID:30165855 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:21394737 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APLP1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of APLP1 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of APLP1 mRNA | CTD | PMID:17942748 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of APLP1 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of APLP1 exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Aplp1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of APLP1 mRNA | CTD | PMID:36041667 | 6-propyl-2-thiouracil | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of APLP1 mRNA | CTD | PMID:30047161 | 6-propyl-2-thiouracil | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of APLP1 mRNA | CTD | PMID:36843608 | acetamide | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of APLP1 mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | APLP1 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of APLP1 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in decreased expression of APLP1 mRNA | CTD | PMID:33354967 | aflatoxin B1 | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of APLP1 mRNA | CTD | PMID:21632981 | all-trans-retinoic acid | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of APLP1 protein | CTD | PMID:16150056 | all-trans-retinoic acid | increases N-linked glycosylation | ISO | APLP1 (Homo sapiens) | 6480464 | Tretinoin results in increased N-linked glycosylation of APLP1 protein | CTD | PMID:16150056 | all-trans-retinoic acid | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | BDNF protein inhibits the reaction [Tretinoin results in increased N-linked glycosylation of APLP1 protein] | CTD | PMID:16150056 | amitrole | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of APLP1 mRNA | CTD | PMID:30047161 | antimycin A | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Antimycin A results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | aristolochic acid A | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of APLP1 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | APLP1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of APLP1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | APLP1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of APLP1 gene | CTD | PMID:25304211 | atrazine | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Atrazine results in increased expression of APLP1 mRNA | CTD | PMID:22378314 | azoxystrobin | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | azoxystrobin results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of APLP1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | APLP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of APLP1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of APLP1 mRNA | CTD | PMID:20106945 and PMID:21632981 | bisphenol A | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of APLP1 mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | multiple interactions | ISO | Aplp1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of APLP1 mRNA | CTD | PMID:36041667 | bisphenol F | multiple interactions | ISO | Aplp1 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of APLP1 mRNA | CTD | PMID:36041667 | butyric acid | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Butyric Acid results in increased expression of APLP1 mRNA | CTD | PMID:34581912 | cisplatin | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of APLP1 mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of APLP1 mRNA | CTD | PMID:27392435 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of APLP1 mRNA | CTD | PMID:16629173 | copper atom | affects localization | ISO | APLP1 (Homo sapiens) | 6480464 | Copper affects the localization of APLP1 protein | CTD | PMID:24855651 | copper atom | affects binding | ISO | APLP1 (Homo sapiens) | 6480464 | APLP1 protein binds to Copper | CTD | PMID:24855651 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of APLP1 mRNA | CTD | PMID:16629173 | copper(0) | affects localization | ISO | APLP1 (Homo sapiens) | 6480464 | Copper affects the localization of APLP1 protein | CTD | PMID:24855651 | copper(0) | affects binding | ISO | APLP1 (Homo sapiens) | 6480464 | APLP1 protein binds to Copper | CTD | PMID:24855651 | crocidolite asbestos | increases expression | EXP | | 6480464 | Asbestos and Crocidolite results in increased expression of APLP1 mRNA | CTD | PMID:29279043 | cyclosporin A | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of APLP1 mRNA | CTD | PMID:27989131 | deguelin | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | deguelin results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | dibenzofurans | decreases expression | EXP | | 6480464 | Dibenzofurans results in decreased expression of APLP1 mRNA | CTD | PMID:34254344 | dieldrin | affects expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Dieldrin affects the expression of APLP1 mRNA | CTD | PMID:22546817 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of APLP1 mRNA | CTD | PMID:25270620 | doxorubicin | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of APLP1 mRNA | CTD | PMID:29803840 and PMID:30031762 | endosulfan | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of APLP1 mRNA | CTD | PMID:29391264 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of APLP1 mRNA | CTD | PMID:30319688 | ethylenediaminetetraacetic acid | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] | CTD | PMID:24855651 | etoposide | decreases expression | EXP | | 6480464 | Etoposide results in decreased expression of APLP1 mRNA | CTD | PMID:25270620 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of APLP1 mRNA | CTD | PMID:22206623 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of APLP1 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of APLP1 mRNA | CTD | PMID:33387578 | Heptachlor epoxide | increases expression | EXP | | 6480464 | Heptachlor Epoxide results in increased expression of APLP1 mRNA | CTD | PMID:25270620 | hydrazine | decreases expression | EXP | | 6480464 | hydrazine results in decreased expression of APLP1 mRNA | CTD | PMID:15282401 | lipopolysaccharide | increases expression | EXP | | 6480464 | Lipopolysaccharides results in increased expression of APLP1 mRNA | CTD | PMID:15919760 | methimazole | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of APLP1 mRNA | CTD | PMID:30047161 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of APLP1 mRNA | CTD | PMID:18502557 | methylmercury chloride | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of APLP1 mRNA | CTD | PMID:28001369 | paracetamol | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of APLP1 mRNA | CTD | PMID:22230336 | picoxystrobin | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of APLP1 mRNA | CTD | PMID:17426115 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of APLP1 mRNA | CTD | PMID:23811191 | pyrimidifen | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | quercetin | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Quercetin results in increased expression of APLP1 mRNA | CTD | PMID:21632981 | rotenone | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of APLP1 mRNA | CTD | PMID:33512557 | sarin | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Sarin results in increased expression of APLP1 mRNA | CTD | PMID:19522546 | silicon dioxide | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of APLP1 mRNA | CTD | PMID:25895662 | sodium arsenite | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of APLP1 mRNA | CTD | PMID:34032870 | sulfadimethoxine | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of APLP1 mRNA | CTD | PMID:30047161 | sulforaphane | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of APLP1 mRNA | CTD | PMID:31838189 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of APLP1 mRNA | CTD | PMID:17555576 | temozolomide | decreases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of APLP1 mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of APLP1 mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of APLP1 mRNA | CTD | PMID:23557971 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of APLP1 mRNA | CTD | PMID:29264374 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of APLP1 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | APLP1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of APLP1 mRNA | CTD | PMID:23179753 and PMID:29154799 | valproic acid | affects expression | ISO | APLP1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of APLP1 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | ISO | Aplp1 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of APLP1 mRNA | CTD | PMID:23034163 | zinc atom | affects localization | ISO | APLP1 (Homo sapiens) | 6480464 | Zinc affects the localization of APLP1 protein | CTD | PMID:24855651 | zinc atom | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] more ... | CTD | PMID:24855651 | zinc atom | affects binding | ISO | APLP1 (Homo sapiens) | 6480464 | APLP1 protein binds to Zinc | CTD | PMID:24855651 | zinc(0) | affects localization | ISO | APLP1 (Homo sapiens) | 6480464 | Zinc affects the localization of APLP1 protein | CTD | PMID:24855651 | zinc(0) | affects binding | ISO | APLP1 (Homo sapiens) | 6480464 | APLP1 protein binds to Zinc | CTD | PMID:24855651 | zinc(0) | multiple interactions | ISO | APLP1 (Homo sapiens) | 6480464 | Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] more ... | CTD | PMID:24855651 | |