DENND2D (DENN domain containing 2D) - Rat Genome Database

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Gene: DENND2D (DENN domain containing 2D) Chlorocebus sabaeus
Analyze
Symbol: DENND2D
Name: DENN domain containing 2D
RGD ID: 18775213
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DENN domain-containing protein 2D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,374,530 - 22,391,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,378,279 - 22,391,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,085,148 - 36,102,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DENND2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,374,530 - 22,391,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,378,279 - 22,391,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,085,148 - 36,102,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DENND2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,185,969 - 111,204,578 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,185,969 - 111,204,535 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,728,591 - 111,747,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,531,324 - 111,544,804 (-)NCBINCBI36Build 36hg18NCBI36
Celera1109,976,779 - 109,990,260 (-)NCBICelera
Cytogenetic Map1p13.3-p13.2NCBI
HuRef1109,600,147 - 109,618,726 (-)NCBIHuRef
CHM1_11111,843,731 - 111,862,311 (-)NCBICHM1_1
T2T-CHM13v2.01111,200,774 - 111,219,466 (-)NCBIT2T-CHM13v2.0
Dennd2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,389,745 - 106,410,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,389,721 - 106,410,346 (+)EnsemblGRCm39 Ensembl
GRCm383106,482,431 - 106,503,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3106,482,405 - 106,503,030 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,285,349 - 106,303,972 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,614,106 - 106,629,098 (+)NCBIMGSCv36mm8
Celera3108,814,378 - 108,832,982 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.49NCBI
Dennd2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,661,465 - 196,680,505 (+)NCBIGRCr8
mRatBN7.22193,973,231 - 193,992,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,973,231 - 193,992,270 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2201,565,765 - 201,584,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02199,472,026 - 199,491,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02194,288,984 - 194,307,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,097,894 - 209,116,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,097,927 - 209,116,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02228,507,586 - 228,526,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,780,928 - 201,799,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,743,755 - 201,762,719 (+)NCBI
Celera2186,655,681 - 186,674,719 (+)NCBICelera
Cytogenetic Map2q34NCBI
Dennd2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,746,553 - 14,764,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,744,226 - 14,764,034 (-)NCBIChiLan1.0ChiLan1.0
DENND2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,838,988 - 115,856,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,987,907 - 115,006,981 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,830,395 - 113,850,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,497,131 - 126,515,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,497,131 - 126,514,484 (+)Ensemblpanpan1.1panPan2
DENND2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,821,016 - 40,836,211 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,821,754 - 40,835,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha643,596,024 - 43,614,302 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,149,953 - 41,168,235 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,149,311 - 41,168,229 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,871,245 - 40,889,500 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,841,183 - 40,859,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,276,466 - 41,294,747 (+)NCBIUU_Cfam_GSD_1.0
Dennd2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,544,930 - 17,561,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,552,591 - 2,569,120 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,552,147 - 2,564,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,121,966 - 109,142,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,121,876 - 109,142,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,300,763 - 119,316,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dennd2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,965,643 - 6,982,558 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,963,788 - 6,982,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DENND2D
254 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000016960   ⟹   ENSCSAP00000016455
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2022,378,279 - 22,391,421 (+)Ensembl
RefSeq Acc Id: XM_007977609   ⟹   XP_007975800
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12022,374,530 - 22,391,855 (+)NCBI
Vero_WHO_p1.0NW_02366603836,085,148 - 36,102,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007977610   ⟹   XP_007975801
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12022,375,042 - 22,391,855 (+)NCBI
Vero_WHO_p1.0NW_02366603836,085,148 - 36,098,829 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007975800 (Get FASTA)   NCBI Sequence Viewer  
  XP_007975801 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016455
  ENSCSAP00000016455.1
RefSeq Acc Id: XP_007975800   ⟸   XM_007977609
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007975801   ⟸   XM_007977610
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S6G6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000016455   ⟸   ENSCSAT00000016960


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016960.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/TrEMBL
  dDENN_dom UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENN_domain_containing_2 UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
NCBI Gene DENND2D ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  DENN DOMAIN-CONTAINING PROTEIN 2D UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PROSITE DENN UniProtKB/TrEMBL
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A0D9S6G6 ENTREZGENE, UniProtKB/TrEMBL