DENND2D (DENN domain containing 2D) - Rat Genome Database

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Gene: DENND2D (DENN domain containing 2D) Sus scrofa
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Symbol: DENND2D
Name: DENN domain containing 2D
RGD ID: 13950249
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DENN domain-containing protein 2D; DENN/MADD domain containing 2D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,121,966 - 109,142,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,121,876 - 109,142,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,300,763 - 119,316,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA)
nucleoplasm  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
DENND2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,121,966 - 109,142,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,121,876 - 109,142,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,300,763 - 119,316,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DENND2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,185,969 - 111,204,578 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,185,969 - 111,204,535 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,728,591 - 111,747,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,531,324 - 111,544,804 (-)NCBINCBI36Build 36hg18NCBI36
Celera1109,976,779 - 109,990,260 (-)NCBICelera
Cytogenetic Map1p13.3-p13.2NCBI
HuRef1109,600,147 - 109,618,726 (-)NCBIHuRef
CHM1_11111,843,731 - 111,862,311 (-)NCBICHM1_1
T2T-CHM13v2.01111,200,774 - 111,219,466 (-)NCBIT2T-CHM13v2.0
Dennd2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,389,745 - 106,410,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,389,721 - 106,410,346 (+)EnsemblGRCm39 Ensembl
GRCm383106,482,431 - 106,503,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3106,482,405 - 106,503,030 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,285,349 - 106,303,972 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,614,106 - 106,629,098 (+)NCBIMGSCv36mm8
Celera3108,814,378 - 108,832,982 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.49NCBI
Dennd2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,661,465 - 196,680,505 (+)NCBIGRCr8
mRatBN7.22193,973,231 - 193,992,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,973,231 - 193,992,270 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2201,565,765 - 201,584,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02199,472,026 - 199,491,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02194,288,984 - 194,307,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,097,894 - 209,116,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,097,927 - 209,116,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02228,507,586 - 228,526,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,780,928 - 201,799,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,743,755 - 201,762,719 (+)NCBI
Celera2186,655,681 - 186,674,719 (+)NCBICelera
Cytogenetic Map2q34NCBI
Dennd2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,746,553 - 14,764,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,744,226 - 14,764,034 (-)NCBIChiLan1.0ChiLan1.0
DENND2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,838,988 - 115,856,425 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,987,907 - 115,006,981 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,830,395 - 113,850,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,497,131 - 126,515,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,497,131 - 126,514,484 (+)Ensemblpanpan1.1panPan2
DENND2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,821,016 - 40,836,211 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,821,754 - 40,835,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha643,596,024 - 43,614,302 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,149,953 - 41,168,235 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,149,311 - 41,168,229 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,871,245 - 40,889,500 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,841,183 - 40,859,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,276,466 - 41,294,747 (+)NCBIUU_Cfam_GSD_1.0
Dennd2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,544,930 - 17,561,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,552,591 - 2,569,120 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,552,147 - 2,564,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,374,530 - 22,391,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,378,279 - 22,391,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,085,148 - 36,102,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,965,643 - 6,982,558 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,963,788 - 6,982,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DENND2D
540 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 5 3
Low 4 3 18 2 3
Below cutoff 1 1 2 5

Sequence


RefSeq Acc Id: ENSSSCT00000007445   ⟹   ENSSSCP00000007250
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4109,121,916 - 109,142,420 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000024251   ⟹   ENSSSCP00000024967
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4109,126,493 - 109,142,718 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045732   ⟹   ENSSSCP00000036864
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4109,121,966 - 109,142,694 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057937   ⟹   ENSSSCP00000034706
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4109,125,954 - 109,142,254 (+)Ensembl
RefSeq Acc Id: XM_001928941   ⟹   XP_001928976
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14109,126,287 - 109,142,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003125854   ⟹   XP_003125902
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14109,124,981 - 109,142,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663560   ⟹   XP_005663617
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14109,121,876 - 109,142,253 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005663617   ⟸   XM_005663560
- Peptide Label: isoform X3
- UniProtKB: A0A481ARR9 (UniProtKB/TrEMBL),   A0A8D1QV29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003125902   ⟸   XM_003125854
- Peptide Label: isoform X2
- UniProtKB: A0A286ZST8 (UniProtKB/TrEMBL),   A0A8D0Z5Z2 (UniProtKB/TrEMBL),   A0A0B8S094 (UniProtKB/TrEMBL),   A0A480QDU9 (UniProtKB/TrEMBL),   A0A4X1TAQ7 (UniProtKB/TrEMBL),   A0A8D0J7A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001928976   ⟸   XM_001928941
- Peptide Label: isoform X1
- UniProtKB: I3LLJ7 (UniProtKB/TrEMBL),   A0A8D1U2Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036864   ⟸   ENSSSCT00000045732
RefSeq Acc Id: ENSSSCP00000007250   ⟸   ENSSSCT00000007445
RefSeq Acc Id: ENSSSCP00000024967   ⟸   ENSSSCT00000024251
RefSeq Acc Id: ENSSSCP00000034706   ⟸   ENSSSCT00000057937
Protein Domains
uDENN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025704 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005025145 UniProtKB/TrEMBL
  ENSSSCG00015010199 UniProtKB/TrEMBL
  ENSSSCG00030037820 UniProtKB/TrEMBL
  ENSSSCG00035025658 UniProtKB/TrEMBL
  ENSSSCG00040023579 UniProtKB/TrEMBL
  ENSSSCG00045036029 UniProtKB/TrEMBL
  ENSSSCG00050054130 UniProtKB/TrEMBL
  ENSSSCG00055014321 UniProtKB/TrEMBL
  ENSSSCG00060020568 UniProtKB/TrEMBL
  ENSSSCG00065034989 UniProtKB/TrEMBL
  ENSSSCG00070007774 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024251 ENTREZGENE
  ENSSSCT00000024251.4 UniProtKB/TrEMBL
  ENSSSCT00000045732 ENTREZGENE
  ENSSSCT00000045732.3 UniProtKB/TrEMBL
  ENSSSCT00000057937 ENTREZGENE
  ENSSSCT00000057937.3 UniProtKB/TrEMBL
  ENSSSCT00005039874.1 UniProtKB/TrEMBL
  ENSSSCT00005039948.1 UniProtKB/TrEMBL
  ENSSSCT00005039989.1 UniProtKB/TrEMBL
  ENSSSCT00015013366.1 UniProtKB/TrEMBL
  ENSSSCT00015013428.1 UniProtKB/TrEMBL
  ENSSSCT00015013778.1 UniProtKB/TrEMBL
  ENSSSCT00030052626.1 UniProtKB/TrEMBL
  ENSSSCT00030052651.1 UniProtKB/TrEMBL
  ENSSSCT00030052677.1 UniProtKB/TrEMBL
  ENSSSCT00030052707.1 UniProtKB/TrEMBL
  ENSSSCT00035033793.1 UniProtKB/TrEMBL
  ENSSSCT00035033801.1 UniProtKB/TrEMBL
  ENSSSCT00035033805.1 UniProtKB/TrEMBL
  ENSSSCT00035033808.1 UniProtKB/TrEMBL
  ENSSSCT00040031572.1 UniProtKB/TrEMBL
  ENSSSCT00040031675.1 UniProtKB/TrEMBL
  ENSSSCT00040031767.1 UniProtKB/TrEMBL
  ENSSSCT00045061872.1 UniProtKB/TrEMBL
  ENSSSCT00045061944.1 UniProtKB/TrEMBL
  ENSSSCT00045062005.1 UniProtKB/TrEMBL
  ENSSSCT00045062053.1 UniProtKB/TrEMBL
  ENSSSCT00050073802.1 UniProtKB/TrEMBL
  ENSSSCT00050073820.1 UniProtKB/TrEMBL
  ENSSSCT00050073823.1 UniProtKB/TrEMBL
  ENSSSCT00055028222.1 UniProtKB/TrEMBL
  ENSSSCT00055028280.1 UniProtKB/TrEMBL
  ENSSSCT00055028347.1 UniProtKB/TrEMBL
  ENSSSCT00055028414.1 UniProtKB/TrEMBL
  ENSSSCT00060027873.1 UniProtKB/TrEMBL
  ENSSSCT00060027876.1 UniProtKB/TrEMBL
  ENSSSCT00060027883.1 UniProtKB/TrEMBL
  ENSSSCT00060027886.1 UniProtKB/TrEMBL
  ENSSSCT00065047638.1 UniProtKB/TrEMBL
  ENSSSCT00070015043.1 UniProtKB/TrEMBL
  ENSSSCT00070015052.1 UniProtKB/TrEMBL
  ENSSSCT00070015065.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.200 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/TrEMBL
  dDENN_dom UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
NCBI Gene DENND2D ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  DENN DOMAIN-CONTAINING PROTEIN 2D UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PROSITE DENN UniProtKB/TrEMBL
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A0B8S094 ENTREZGENE
  A0A286ZST8 ENTREZGENE, UniProtKB/TrEMBL
  A0A286ZZE0_PIG UniProtKB/TrEMBL
  A0A480QDU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A481ARR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TAK9_PIG UniProtKB/TrEMBL
  A0A4X1TAQ7 ENTREZGENE
  A0A4X1TCM3_PIG UniProtKB/TrEMBL
  A0A8D0J7A9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JCJ5_PIG UniProtKB/TrEMBL
  A0A8D0Z5Z2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Z9E3_PIG UniProtKB/TrEMBL
  A0A8D0ZBK8_PIG UniProtKB/TrEMBL
  A0A8D0ZCJ5_PIG UniProtKB/TrEMBL
  A0A8D1J144_PIG UniProtKB/TrEMBL
  A0A8D1J5Z4_PIG UniProtKB/TrEMBL
  A0A8D1N5U8_PIG UniProtKB/TrEMBL
  A0A8D1QV29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1U2Q8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UNF4_PIG UniProtKB/TrEMBL
  I3LLJ7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1TAQ7 UniProtKB/TrEMBL
VGNC ID VGNC:87249 ENTREZGENE