IMPDH1 (inosine monophosphate dehydrogenase 1) - Rat Genome Database

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Gene: IMPDH1 (inosine monophosphate dehydrogenase 1) Chlorocebus sabaeus
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Symbol: IMPDH1
Name: inosine monophosphate dehydrogenase 1
RGD ID: 18761795
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN 'de novo' XMP biosynthetic process (ortholog); lymphocyte proliferation (ortholog); purine nucleotide biosynthetic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH fundus dystrophy (ortholog); genetic disease (ortholog); Leber congenital amaurosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inosine-5'-monophosphate dehydrogenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,188,835 - 97,231,871 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,189,481 - 97,206,726 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,199,094 - 6,217,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IMPDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,188,835 - 97,231,871 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,189,481 - 97,206,726 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,199,094 - 6,217,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
IMPDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,392,277 - 128,409,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,392,277 - 128,409,986 (-)EnsemblGRCh38hg38GRCh38
GRCh377128,032,331 - 128,050,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,819,567 - 127,837,272 (-)NCBINCBI36Build 36hg18NCBI36
Build 347127,626,282 - 127,643,992NCBI
Celera7122,835,429 - 122,853,135 (-)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,393,708 - 122,411,003 (-)NCBIHuRef
CHM1_17127,965,901 - 127,983,582 (-)NCBICHM1_1
T2T-CHM13v2.07129,704,030 - 129,721,735 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,415,442 - 127,433,147 (-)NCBI
Impdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,200,435 - 29,216,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,200,433 - 29,216,363 (-)EnsemblGRCm39 Ensembl
GRCm38629,200,436 - 29,216,364 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,200,434 - 29,216,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv37629,150,440 - 29,162,271 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,150,450 - 29,162,281 (-)NCBIMGSCv36mm8
Celera629,206,299 - 29,218,129 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Impdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,767,230 - 58,782,825 (-)NCBIGRCr8
mRatBN7.2457,801,842 - 57,817,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,801,831 - 57,819,076 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,784,631 - 62,800,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,700,781 - 58,716,310 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,102,678 - 57,118,207 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,478,383 - 56,493,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,478,384 - 56,493,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,245,545 - 56,261,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,075,236 - 56,090,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,328,720 - 56,344,413 (-)NCBI
Celera452,909,914 - 52,925,453 (-)NCBICelera
Cytogenetic Map4q22NCBI
Impdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,388,108 - 9,406,764 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,388,241 - 9,406,717 (-)NCBIChiLan1.0ChiLan1.0
IMPDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,246,060 - 165,263,800 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,256,310 - 17,274,047 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,382,719 - 120,400,417 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,036,328 - 133,053,496 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,036,328 - 133,053,580 (-)Ensemblpanpan1.1panPan2
IMPDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,001,575 - 8,013,181 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,996,717 - 8,012,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,683,371 - 7,699,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,763,475 - 7,779,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,763,396 - 7,779,755 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,968,180 - 7,984,460 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,709,322 - 7,725,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,855,531 - 7,872,037 (+)NCBIUU_Cfam_GSD_1.0
Impdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,399,577 - 54,416,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,523,037 - 15,540,173 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,523,342 - 15,540,229 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,979,983 - 19,996,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11819,979,983 - 19,996,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,049,179 - 21,065,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Impdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,574,093 - 7,590,909 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,574,025 - 7,590,920 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000008166   ⟹   ENSCSAP00000006318
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2197,189,481 - 97,206,726 (-)Ensembl
RefSeq Acc Id: XM_007982831   ⟹   XP_007981022
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12197,188,835 - 97,231,871 (-)NCBI
Vero_WHO_p1.0NW_0236660426,199,530 - 6,217,528 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007982835   ⟹   XP_007981026
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12197,188,835 - 97,206,964 (-)NCBI
Vero_WHO_p1.0NW_0236660426,199,532 - 6,217,528 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038004407   ⟹   XP_037860335
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,529 - 6,217,528 (+)NCBI
RefSeq Acc Id: XM_038004408   ⟹   XP_037860336
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,094 - 6,217,528 (+)NCBI
RefSeq Acc Id: XM_038004409   ⟹   XP_037860337
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,532 - 6,217,528 (+)NCBI
RefSeq Acc Id: XM_038004410   ⟹   XP_037860338
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,533 - 6,217,522 (+)NCBI
RefSeq Acc Id: XM_038004411   ⟹   XP_037860339
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,531 - 6,217,528 (+)NCBI
RefSeq Acc Id: XM_038004412   ⟹   XP_037860340
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660426,199,533 - 6,217,522 (+)NCBI
RefSeq Acc Id: XP_007981022   ⟸   XM_007982831
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007981026   ⟸   XM_007982835
- Peptide Label: isoform X8
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000006318   ⟸   ENSCSAT00000008166
RefSeq Acc Id: XP_037860336   ⟸   XM_038004408
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860335   ⟸   XM_038004407
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860339   ⟸   XM_038004411
- Peptide Label: isoform X6
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860337   ⟸   XM_038004409
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860338   ⟸   XM_038004410
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860340   ⟸   XM_038004412
- Peptide Label: isoform X7
- UniProtKB: A0A0D9RCH9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010128 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008166.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  CBS_dom UniProtKB/TrEMBL
  IMP_DH UniProtKB/TrEMBL
  IMP_DH/GMP_Rdtase_CS UniProtKB/TrEMBL
  IMP_DH_GMPRt UniProtKB/TrEMBL
NCBI Gene IMPDH1 ENTREZGENE
PANTHER INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 UniProtKB/TrEMBL
  PTHR11911 UniProtKB/TrEMBL
Pfam CBS UniProtKB/TrEMBL
  IMPDH UniProtKB/TrEMBL
PROSITE CBS UniProtKB/TrEMBL
  IMP_DH_GMP_RED UniProtKB/TrEMBL
SMART CBS UniProtKB/TrEMBL
  IMPDH UniProtKB/TrEMBL
Superfamily-SCOP Inosine monophosphate dehydrogenase (IMPDH) UniProtKB/TrEMBL
UniProt A0A0D9RCH9 ENTREZGENE, UniProtKB/TrEMBL