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Gene: LOC103231893 (synapsin-1) Chlorocebus sabaeus

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Symbol:

LOC103231893 (Ensembl: SYN1)

Name:

synapsin-1 (Ensembl:synapsin I)

RGD ID:

18755424

Description:

ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); INVOLVED IN neuron development (ortholog); neurotransmitter secretion (ortholog); synapse organization (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); congenital disorder of glycosylation type IIm (ortholog); FOUND IN axon (ortholog); cell body (ortholog); dendrite (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

SYN1; synapsin I

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SYN1 (synapsin I)	NCBI	Ortholog
Mus musculus (house mouse):	Syn1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Syn1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Syn1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SYN1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SYN1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Syn1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SYN1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Syn1 (synapsin I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,748,994 - 44,797,053 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,750,046 - 44,797,009 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666566	1,064 - 38,215 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

congenital disorder of glycosylation type IIm (ISO)

epilepsy (ISO)

genetic disease (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

Insulin Resistance (ISO)

intellectual disability (ISO)

major depressive disorder (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

Neurodevelopmental Disorders (ISO)

non-syndromic X-linked intellectual disability 50 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

neuron development (ISO)

neurotransmitter secretion (IEA,ISO)

regulation of synaptic vesicle cycle (IEA)

regulation of synaptic vesicle exocytosis (IEA)

synapse organization (ISO)

synaptic vesicle cycle (IEA)

Cellular Component

axon (IEA,ISO)

cell body (IEA,ISO)

cell projection (IEA)

cytoplasmic vesicle (IEA)

cytoskeleton (IEA)

dendrite (IEA,ISO)

extrinsic component of synaptic vesicle membrane (ISO)

Golgi apparatus (IEA)

postsynaptic density (IEA)

presynapse (IEA)

presynaptic active zone (IEA)

Schaffer collateral - CA1 synapse (IEA,ISO)

synapse (IEA)

synaptic vesicle (IEA)

synaptic vesicle membrane (IEA)

synaptonemal complex (IEA)

Molecular Function

actin binding (IEA)

ATP binding (IEA)

calcium-dependent protein binding (ISO)

identical protein binding (IEA)

protein binding (ISO)

protein kinase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC103231893
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,748,994 - 44,797,053 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,750,046 - 44,797,009 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666566	1,064 - 38,215 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SYN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	47,571,901 - 47,619,857 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	47,571,901 - 47,619,857 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	47,431,300 - 47,479,256 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	47,316,244 - 47,364,200 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	47,188,586 - 47,235,511	NCBI
Celera	X	51,626,557 - 51,674,518 (-)	NCBI		Celera
Cytogenetic Map	X	p11.3-p11.23	NCBI
HuRef	X	45,143,520 - 45,192,091 (-)	NCBI		HuRef
CHM1_1	X	47,462,402 - 47,510,356 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,981,791 - 47,029,757 (-)	NCBI		T2T-CHM13v2.0

Syn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	20,726,750 - 20,787,157 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	20,726,750 - 20,787,243 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	20,860,511 - 20,920,918 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,860,511 - 20,921,004 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	20,437,637 - 20,498,044 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	20,017,470 - 20,077,855 (-)	NCBI		MGSCv36	mm8
Celera	X	18,991,650 - 19,054,780 (-)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI
cM Map	X	16.37	NCBI

Syn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	3,725,745 - 3,780,940 (+)	NCBI		GRCr8
mRatBN7.2	X	1,172,208 - 1,227,400 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,172,208 - 1,227,396 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,200,284 - 1,255,539 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,675,978 - 4,731,230 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	997,205 - 1,052,394 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,321,315 - 1,379,202 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,321,315 - 1,379,198 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,136,336 - 2,194,393 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,512,241 - 12,556,160 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,585,157 - 12,585,610 (-)	NCBI
Celera	X	1,741,094 - 1,795,235 (+)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

Syn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	460,198 - 521,484 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955516	460,258 - 521,484 (+)	NCBI	ChiLan1.0	ChiLan1.0

SYN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	49,198,319 - 49,246,366 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	49,201,691 - 49,249,738 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	40,007,777 - 40,055,801 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	47,905,598 - 47,951,786 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SYN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,191,571 - 41,241,557 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,191,571 - 41,241,640 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,566,597 - 15,616,166 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,325,757 - 41,375,351 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,325,762 - 41,375,291 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,313,364 - 41,362,911 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,301,640 - 41,351,196 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,394,278 - 41,443,858 (-)	NCBI		UU_Cfam_GSD_1.0

Syn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	33,494,248 - 33,546,336 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	13,334,995 - 13,387,172 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	13,334,998 - 13,387,082 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SYN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,090,246 - 42,142,224 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	42,090,245 - 42,142,254 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,336,634 - 47,388,655 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Syn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624978	110,506 - 180,568 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624978	110,640 - 179,910 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LOC103231893
656 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	18	34	34	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007991542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007991543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037995863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037995864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011715 ⟹ ENSCSAP00000009779

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	X	44,750,046 - 44,797,009 (-)	Ensembl

RefSeq Acc Id:

XM_037995863 ⟹ XP_037851791

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666566	1,064 - 38,215 (+)	NCBI

RefSeq Acc Id:

XM_037995864 ⟹ XP_037851792

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666566	1,064 - 38,215 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_037851791	(Get FASTA)	NCBI Sequence Viewer
	XP_037851792	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009779.1

Ensembl Acc Id:

ENSCSAP00000009779 ⟸ ENSCSAT00000011715

RefSeq Acc Id:	XP_037851791 ⟸ XM_037995863
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037851792 ⟸ XM_037995864
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013616	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011715.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1490.20	UniProtKB/TrEMBL
	3.40.50.20	UniProtKB/TrEMBL
	ATP-grasp fold, B domain	UniProtKB/TrEMBL
InterPro	ATP_grasp_subdomain_1	UniProtKB/TrEMBL
	PreATP-grasp_dom_sf	UniProtKB/TrEMBL
	Synapsin	UniProtKB/TrEMBL
	Synapsin_ATP-bd_dom	UniProtKB/TrEMBL
	Synapsin_CS	UniProtKB/TrEMBL
	Synapsin_P_site	UniProtKB/TrEMBL
	Synapsin_pre-ATP-grasp_dom	UniProtKB/TrEMBL
NCBI Gene	SYN1	ENTREZGENE
PANTHER	PTHR10841:SF24	UniProtKB/TrEMBL
	SYNAPSIN	UniProtKB/TrEMBL
Pfam	Synapsin	UniProtKB/TrEMBL
	Synapsin_C	UniProtKB/TrEMBL
	Synapsin_N	UniProtKB/TrEMBL
PRINTS	SYNAPSIN	UniProtKB/TrEMBL
PROSITE	SYNAPSIN_1	UniProtKB/TrEMBL
	SYNAPSIN_2	UniProtKB/TrEMBL
Superfamily-SCOP	Glutathione synthetase ATP-binding domain-like	UniProtKB/TrEMBL
	SSF52440	UniProtKB/TrEMBL
UniProt	A0A0D9RME0_CHLSB	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	LOC103231893	synapsin-1	SYN1	synapsin I	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM