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Gene: TSKU (tsukushi, small leucine rich proteoglycan) Chlorocebus sabaeus

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Symbol:

TSKU

Name:

tsukushi, small leucine rich proteoglycan

RGD ID:

18742981

Description:

ENCODES a protein that exhibits transforming growth factor beta binding (inferred); INVOLVED IN anterior commissure morphogenesis (ortholog); camera-type eye development (ortholog); ciliary body morphogenesis (ortholog); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tsukushin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	67,988,729 - 68,003,959 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	68,001,429 - 68,002,490 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	57,785,591 - 57,800,748 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior commissure morphogenesis (IEA,ISO)

camera-type eye development (IEA,ISO)

cholesterol efflux (IEA)

cholesterol homeostasis (IEA)

cholesterol metabolic process (IEA)

ciliary body morphogenesis (IEA,ISO)

corpus callosum morphogenesis (IEA,ISO)

energy homeostasis (IEA,ISO)

hippocampus development (IEA)

inner ear receptor cell stereocilium organization (IEA)

lateral ventricle development (IEA,ISO)

negative regulation of myofibroblast differentiation (IEA)

negative regulation of neuron projection development (IEA)

negative regulation of transforming growth factor beta1 production (IEA)

negative regulation of Wnt signaling pathway (IEA,ISO)

positive regulation of hair cycle (IEA)

regulation of gene expression (IEA,ISO)

wound healing (IEA)

Cellular Component

extracellular space (IEA,ISO)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

transforming growth factor beta binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TSKU
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	67,988,729 - 68,003,959 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	68,001,429 - 68,002,490 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	57,785,591 - 57,800,748 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TSKU
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	76,782,280 - 76,798,144 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	76,782,251 - 76,798,153 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	76,493,324 - 76,509,188 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	76,171,933 - 76,186,846 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	73,801,738 - 73,816,651 (+)	NCBI		Celera
Cytogenetic Map	11	q13.5	NCBI
HuRef	11	72,791,056 - 72,806,897 (+)	NCBI		HuRef
CHM1_1	11	76,376,410 - 76,392,251 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	76,712,593 - 76,728,455 (+)	NCBI		T2T-CHM13v2.0

Tsku
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	97,999,875 - 98,010,602 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	97,999,875 - 98,010,535 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	98,350,668 - 98,361,390 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	98,350,668 - 98,361,328 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	105,499,178 - 105,509,838 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	98,226,060 - 98,236,480 (-)	NCBI		MGSCv36	mm8
Celera	7	98,670,613 - 98,681,273 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI
cM Map	7	53.66	NCBI

Tsku
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	162,071,459 - 162,082,972 (-)	NCBI		GRCr8
mRatBN7.2	1	152,660,259 - 152,671,682 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	152,656,693 - 152,672,588 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	160,648,580 - 160,659,888 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,828,744 - 167,840,052 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	160,702,272 - 160,713,580 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	163,317,281 - 163,328,697 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	163,317,282 - 163,328,591 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	169,524,020 - 169,535,831 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	155,611,069 - 155,622,378 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	155,689,480 - 155,700,780 (-)	NCBI
Celera	1	150,750,146 - 150,761,455 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Tsku
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	15,166,349 - 15,178,284 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	15,166,349 - 15,178,284 (-)	NCBI	ChiLan1.0	ChiLan1.0

TSKU
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	77,704,718 - 77,719,598 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	78,750,093 - 78,764,950 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	71,833,654 - 71,848,509 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	75,480,674 - 75,495,449 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	75,492,912 - 75,493,973 (+)	Ensembl	panpan1.1		panPan2

TSKU
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	21,910,333 - 21,927,758 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	21,915,956 - 21,928,119 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	21,743,504 - 21,757,126 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	22,116,699 - 22,130,306 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	22,116,701 - 22,130,823 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	21,887,862 - 21,901,417 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	22,107,232 - 22,120,834 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	22,030,572 - 22,044,179 (-)	NCBI		UU_Cfam_GSD_1.0

Tsku
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	63,835,116 - 63,887,751 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	5,434,911 - 5,447,147 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	5,434,912 - 5,487,354 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSKU
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	10,927,342 - 10,942,668 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	10,927,224 - 10,940,851 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	12,036,689 - 12,050,312 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tsku
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	366,101 - 373,034 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	364,543 - 379,742 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TSKU
440 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
75	36	17	33	33	59	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008020218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017917 ⟹ ENSCSAP00000017388

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	68,001,429 - 68,002,490 (+)	Ensembl

RefSeq Acc Id:

XM_008020218 ⟹ XP_008018409

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	1	67,988,729 - 68,003,959 (+)	NCBI
Vero_WHO_p1.0	NW_023666043	57,785,591 - 57,800,748 (-)	NCBI

Sequence:

show sequence

CTGGCCCGAGCAGCCACCCGGCGCCCGGCAGGGGGGAGCCCGGCTACGAGCGGGGACCGGGGGG
CGGGCCGCGCCGCCGGGAGAAAAGCGCCGGCCGGAGGGCCCGCGGCCGGGCCGCCGGGGTGAGC
GTGCCGAGGCGGCTGCGGCGCAGGCTTCCAGCCCCCACCATGCCGTGGCCCCTGCTGCTGCTGC
TGGCCGTGAGTGGGGCCCAGACAACCCGGCCATGCTTTCCCGGGTGCCAGTGCGAGGTGGAGAC
CTTCGGCCTTTTCGACAGCTTCAGCCTGACTCGGGTGGATTGCAGTGGCTTGGGCTCCCACATC
ATGCCAGTGCCCATCCCTTTGGACACAGCCCACTTGGACCTGTCCTCCAACCGGCTAGAGATGG
TGAACGAGTCGGTGTTGGCAGGGCCGGGCTACACGACGCTGGCTGGCCTGGATCTCAGCCACAA
CCTGCTCACCAGCATCTCACCCACTGCCTTCTCCCGCCTTCGTTACCTGGAGTCGCTTGACCTC
AGCCACAATGGCCTGACGGCCCTGCCAGCCGAGAGCTTCACCAGCTCACCCCTGAGTGACGTGA
ACCTTAGCCACAACCAGCTCCGGGAGGTCTCAGTGTCCGCCTTCACGACCCACAGTCAGGGCCG
GGCACTGCACGTGGACCTCTCCCACAACCTCATTCACCGCCTCGTGCCCCACCCTGCGAGGGCC
GGCCTGCCTGCGCCCACCATTCAGAGCCTGAACCTGGCCTGGAACCGGCTCCATGCCGTGCCCA
ACCTCCAAGACTTGCCCCTGCGCTACCTGAGCCTGGATGGGAACCCTCTAGCTGTCATTGGTCC
GGGTGCCTTCGCAGGGCTGACAGGCCTTACACACCTGTCTCTGGCCAGCCTGCAGAGGCTCCCT
GAGCTGGCGCCCTATGGCTTCCGCGAGCTACCGGGACTGCAGGTCCTGGACCTGTCGGGCAACC
CCAAGCTCAACTGGGCAGGAGCTGAGGTGTTCTCAGGCCTGAACTCCCTGCAGGAGCTGGACCT
TTCGGGCACCAACCTGGTGCCCCTGCCTGAGGCGCTGCTTCTCCACCTCCCGGCACTGCAGAGT
GTCAGCGTGGGCCAGGATGTGTGGTGCCGGCGCCTGGTACGGGAGGGTGCCTACCCCCGAAGGC
CTGGCTCCAGCCCCAAGGTGGCCCTGCACTGCGTAGACACCCGGGAATCTGCTGCCAGGGGCCC
CAATATCTTGTGACGAATGGTGTGGCCCAGGGCCACATAGCAGACTGCTGTCCTGGGCTGCCTC
TGGTCCCGAGTGACTTATGTTCCATGTGCCAACACCAGTGGGGAGCCCGCAGGCCTATGTTGCA
GCATCACTGCAGGAGTTGTGGGCCTAGGAGAGGCTTTGGACCTGGGAGTCACACCTAGCAGCAA
AGTCTCGCCCCTTTGTCTACGTTGCTCCCCCAAACCATGAGCAGAGGGACTTCGATGCCAAACC
AGACTCTGGTCCCCTCCTGCTTCCCTTCCCCACTTATCCCCCAAGTGCCTTCCCTCATGGCTGG
GCCGGCCTGACCCGAGACAGGCAGAGGGTGGGTGGGACCCCCTGCTGCAAGGCAGAGTTCAGGC
CCACTGGGCTGAGTGTCCCCTTGGGCCCGTGGCCCAGTCACTCAGGGGCATGAGTTTATTTTCT
AACATAGCCCTTTCTTTGCCATGAGGCCGTGAGACCCACTTCCTCCTTTTCTATTTCCCTAGAA
CCTTAATGGTAGAAGGAATTGCAAAGAATCAAGTCCACCCTTCTCATGTGACAGATGGGGAAAC
TGAGGCCTTGAGAAGGAAAAAGGCTAATCTGAGTTCCTACGGGGCAGTGGCACGACTGGAGCAC
AGCCTCCTGCCTCCCAGCTGGGCCCATTGCACTTTCTTGTCTCCTCTAATAAGCCCCGCCCTCC
CCGCCTGGGCTCCCCTTGCTGCCCTTGCCCATTCCCCATTAGCACAAGAGTAGCAGCAGCAGGA
CAGGCAAGAGCCTCACAAGTGGGACTCTGGGCCTGGTGACCAGCTGTGTGGCACGGGCTAAGTC
ACTCTGCCCTTCGGAGCCTCTGGAAGCTTAGGGCACATTGGTTCCAGCCTAGCCAGTTTCTCAC
CCTGGGTTGGGGTCCCCCAGCATCCAGACTGGAAACCTACCCATTTTCCCCTGAGCATCCTCTA
GATACTGCCCCAAGGAGTTGCTGCAGTTCTGGAGTCTCATCTGGCCGGGAGCTCCAAGGGGCCT
CCTGGATTCAGTCCCCACTGGCCCTGAGTACGACAGCCCTTCTCACCCTCCCAGGAATGCCGTG
AAAGGAGGCAAGGTCTCCCCCACCCATGTCTATGCTCGACCCCCAGGGTAGCATCTCAGCTTCC
AAACCCTGGGCTGTTTCCTTAGTCTTCATTTTATAAAAGTTGTTGCCTTTTTAATGGACTGTCA
CTTTCAACCCGCCTCCCCCACCCCTGCTGGCCGGGGATGGAGACATGTCATTTGTAAAAGCAAG
AAAAGGTTGCATTTGTTCACTTTTGTGATATTGTCCTGGGCCTGTGTTGCGGTGTTGGGGGAAG
CTGGGCATCAGTGGCCACGTGGGCATCAGGGGCTGGCCCCACAGAGACCCCACAGGGCAGTGAG
CTCTGTCTTCTCCCACCTGCCTAGCCCATCATCTATCTGACTGGTCCTTGATTTAATAAACACC
ATAAAAAGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008018409	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017388.1

RefSeq Acc Id:	XP_008018409 ⟸ XM_008020218
- UniProtKB:	A0A0D9S949 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000017388 ⟸ ENSCSAT00000017917

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000618	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017917.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	LRR_TM_domain-containing	UniProtKB/TrEMBL
KEGG Report	csab:103248085	UniProtKB/TrEMBL
NCBI Gene	TSKU	ENTREZGENE
PANTHER	ANTIGEN BSP, PUTATIVE-RELATED	UniProtKB/TrEMBL
	CHAOPTIN-RELATED	UniProtKB/TrEMBL
Pfam	LRR_1	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PRINTS	LEURICHRPT	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
SMART	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	A0A0D9S949	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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