GMPR2 (guanosine monophosphate reductase 2) - Rat Genome Database

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Gene: GMPR2 (guanosine monophosphate reductase 2) Chlorocebus sabaeus
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Symbol: GMPR2
Name: guanosine monophosphate reductase 2
RGD ID: 18741819
Description: ENCODES a protein that exhibits GMP reductase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN GMP metabolic process (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); dyskeratosis congenita (ortholog); FOUND IN GMP reductase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GMP reductase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,215,137 - 1,222,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,215,357 - 1,225,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,899,552 - 12,906,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
GMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,215,137 - 1,222,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,215,357 - 1,225,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,899,552 - 12,906,635 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,232,622 - 24,239,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,232,422 - 24,239,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,701,828 - 24,708,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,771,488 - 23,778,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,771,942 - 23,778,285NCBI
Celera144,566,286 - 4,573,086 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,816,418 - 4,823,218 (+)NCBIHuRef
CHM1_11424,700,271 - 24,707,071 (+)NCBICHM1_1
T2T-CHM13v2.01418,430,995 - 18,437,615 (+)NCBIT2T-CHM13v2.0
Gmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,909,692 - 55,935,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,909,398 - 55,916,657 (+)EnsemblGRCm39 Ensembl
GRCm381455,672,235 - 55,687,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,671,941 - 55,679,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,291,072 - 56,297,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,626,307 - 54,633,271 (+)NCBIMGSCv36mm8
Celera1453,477,308 - 53,483,824 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Gmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,135,455 - 33,144,923 (+)NCBIGRCr8
mRatBN7.21529,165,421 - 29,175,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,165,783 - 29,174,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,011,501 - 31,020,661 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,158,722 - 32,167,882 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,401,065 - 30,410,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,352,857 - 34,362,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,352,914 - 34,362,032 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,242,834 - 38,252,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,820,865 - 33,830,025 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,836,608 - 33,840,631 (+)NCBI
Celera1528,742,209 - 28,751,367 (+)NCBICelera
Cytogenetic Map15p13NCBI
Gmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,166,129 - 36,173,245 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,166,129 - 36,173,247 (-)NCBIChiLan1.0ChiLan1.0
GMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,586,650 - 25,594,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,803,398 - 24,810,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,008,664 - 5,015,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,132,227 - 23,139,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,132,227 - 23,139,044 (+)Ensemblpanpan1.1panPan2
GMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,213,238 - 4,220,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,213,373 - 4,220,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,134,799 - 4,142,420 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,323,889 - 4,331,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,324,117 - 4,331,509 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,014,274 - 4,021,895 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,076,063 - 4,083,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,338,401 - 4,346,026 (+)NCBIUU_Cfam_GSD_1.0
Gmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,058,339 - 36,065,069 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936722323,917 - 330,648 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,060,676 - 75,070,084 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,060,680 - 75,070,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,331,603 - 80,340,768 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Gmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,312,386 - 8,319,799 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,312,253 - 8,319,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 5 48
Low 15 12
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000014055   ⟹   ENSCSAP00000012036
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl241,215,357 - 1,225,716 (+)Ensembl
RefSeq Acc Id: XM_007986311   ⟹   XP_007984502
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1241,215,915 - 1,222,219 (+)NCBI
Vero_WHO_p1.0NW_02366603612,900,165 - 12,906,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007986312   ⟹   XP_007984503
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1241,215,137 - 1,222,219 (+)NCBI
Vero_WHO_p1.0NW_02366603612,899,552 - 12,906,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007986313   ⟹   XP_007984504
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1241,215,137 - 1,222,219 (+)NCBI
Vero_WHO_p1.0NW_02366603612,899,572 - 12,906,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007986314   ⟹   XP_007984505
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1241,215,592 - 1,222,219 (+)NCBI
Vero_WHO_p1.0NW_02366603612,899,996 - 12,906,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037985544   ⟹   XP_037841472
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603612,899,774 - 12,906,635 (+)NCBI
RefSeq Acc Id: XM_037985547   ⟹   XP_037841475
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603612,899,620 - 12,906,635 (+)NCBI
RefSeq Acc Id: XM_037985548   ⟹   XP_037841476
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603612,900,037 - 12,906,635 (+)NCBI
RefSeq Acc Id: XM_037985552   ⟹   XP_037841480
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603612,899,552 - 12,906,635 (+)NCBI
RefSeq Acc Id: XP_007984503   ⟸   XM_007986312
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RTU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007984504   ⟸   XM_007986313
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RTU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007984505   ⟸   XM_007986314
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RTU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007984502   ⟸   XM_007986311
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RTU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012036   ⟸   ENSCSAT00000014055
RefSeq Acc Id: XP_037841480   ⟸   XM_037985552
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RTU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841475   ⟸   XM_037985547
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037841472   ⟸   XM_037985544
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037841476   ⟸   XM_037985548
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014055.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  GMPR UniProtKB/TrEMBL
  IMP_DH/GMP_Rdtase_CS UniProtKB/TrEMBL
  IMP_DH_GMPRt UniProtKB/TrEMBL
NCBI Gene GMPR2 ENTREZGENE
PANTHER GMP REDUCTASE UniProtKB/TrEMBL
  GMP REDUCTASE 2 UniProtKB/TrEMBL
Pfam IMPDH UniProtKB/TrEMBL
PIRSF GMP_reductase UniProtKB/TrEMBL
PROSITE IMP_DH_GMP_RED UniProtKB/TrEMBL
SMART IMPDH UniProtKB/TrEMBL
Superfamily-SCOP Inosine monophosphate dehydrogenase (IMPDH) UniProtKB/TrEMBL
UniProt A0A0D9RTU7 ENTREZGENE, UniProtKB/TrEMBL