Gmpr2 (guanosine monophosphate reductase 2)

Gene: Gmpr2 (guanosine monophosphate reductase 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Gmpr2

Name:

guanosine monophosphate reductase 2

RGD ID:

12451646

Description:

ENCODES a protein that exhibits GMP reductase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN GMP metabolic process (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); dyskeratosis congenita (ortholog); FOUND IN GMP reductase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GMP reductase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,058,339 - 36,065,069 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936722	323,917 - 330,648 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

GMP metabolic process (ISO)

nucleotide metabolic process (IEA)

purine nucleobase metabolic process (IEA)

purine nucleotide metabolic process (IEA)

Cellular Component

GMP reductase complex (IEA)

Molecular Function

GMP reductase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Gmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,058,339 - 36,065,069 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936722	323,917 - 330,648 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMPR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,232,622 - 24,239,242 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,232,422 - 24,239,242 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,701,828 - 24,708,448 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,771,488 - 23,778,288 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,771,942 - 23,778,285	NCBI
Celera	14	4,566,286 - 4,573,086 (+)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,816,418 - 4,823,218 (+)	NCBI		HuRef
CHM1_1	14	24,700,271 - 24,707,071 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,430,995 - 18,437,615 (+)	NCBI		T2T-CHM13v2.0

Gmpr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,909,692 - 55,935,602 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,909,398 - 55,916,657 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,672,235 - 55,687,861 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,671,941 - 55,679,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,291,072 - 56,297,588 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,626,307 - 54,633,271 (+)	NCBI		MGSCv36	mm8
Celera	14	53,477,308 - 53,483,824 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Gmpr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,135,455 - 33,144,923 (+)	NCBI		GRCr8
mRatBN7.2	15	29,165,421 - 29,175,933 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,165,783 - 29,174,935 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	31,011,501 - 31,020,661 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,158,722 - 32,167,882 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,401,065 - 30,410,221 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,352,857 - 34,362,074 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,352,914 - 34,362,032 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,242,834 - 38,252,051 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,820,865 - 33,830,025 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,836,608 - 33,840,631 (+)	NCBI
Celera	15	28,742,209 - 28,751,367 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

Gmpr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	36,166,129 - 36,173,245 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	36,166,129 - 36,173,247 (-)	NCBI	ChiLan1.0	ChiLan1.0

GMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,586,650 - 25,594,233 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,803,398 - 24,810,725 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,008,664 - 5,015,461 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,132,227 - 23,139,044 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,132,227 - 23,139,044 (+)	Ensembl	panpan1.1		panPan2

GMPR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,213,238 - 4,220,740 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,213,373 - 4,220,740 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,134,799 - 4,142,420 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,323,889 - 4,331,513 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,324,117 - 4,331,509 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,014,274 - 4,021,895 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,076,063 - 4,083,696 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,338,401 - 4,346,026 (+)	NCBI		UU_Cfam_GSD_1.0

GMPR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,060,676 - 75,070,084 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,060,680 - 75,070,079 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,331,603 - 80,340,768 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GMPR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,215,137 - 1,222,219 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,215,357 - 1,225,716 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,899,552 - 12,906,635 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmpr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,312,386 - 8,319,799 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,312,253 - 8,319,585 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013364500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_013364500 ⟹ XP_013219954

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	36,058,339 - 36,065,069 (+)	NCBI
SpeTri2.0	NW_004936722	323,917 - 330,648 (-)	NCBI

Sequence:

show sequence

ATGCCGGAAGTTGATTGAAACCTTCCCATTTCTTTTCCCTAAACCTGACTCCTCATTGCAGGGG
TGGGCAGGGAAAGTAGCTGGGTAAAGTGAACACTTCGGTTCACCAACCCAATTCTACCCAACAA
TCTGTACTTGAGATGGAAGCATCGAGGCCAGGACGAGTGCCGGCGATCTGCTTCAGGGCCCAAA
CCTTGCCTTATAACCCGACCTTCCACGATTTAAGCCAGGAGAGATGCATCCTGTCCCAGCCACA
TCAGGACATTAAGGCCCAAGGGAATATTGATTCAGATTCCTCCTGACTTCCTACCCTCCAATAC
TCAGATTCCAGACCCCGCCATGCCTCATATCGACAATGACGTGAAACTAGACTTCAAGGATGTT
CTTTTGAGGCCAAAACGCAGCACCCTAAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTTTT
CATTTCGGAATTCAAAGCAGATGTACAATGGCGTCCCGATCATTGCTGCTAATATGGATACTGT
AGGCACCTTTGAAATGGCCAAGGTTCTTTGTAAGTTCTCCCTCTTCACTGCTGTCCATAAACAT
TACAGTCTTCATCAGTGGCAAGAGTTTGCTGGCCAGAATCCTGATTGTCTTCAGTATCTGGCTG
CCAGTTCAGGGACAGGCTCTTCTGACTTTGAGCAACTGGAACAGATCCTGGAAGCTATTCCCCA
GGTGAAATATATATGCCTAGATGTGGCAAATGGCTACTCTGAACACTTTGTTGAATTTGTAAAG
GATGTACGGAAGCGCTTCCCTCAACACACCATCATGGCAGGGAATGTGGTCACAGGAGAGATGG
TGGAAGAGTTGATCCTCTCTGGGGCTGACATCATCAAAGTGGGAATTGGGCCAGGCTCTGTGTG
TACAACCCGGAAGAAAACTGGAGTGGGGTATCCACAGCTCAGTGCAGTGATGGAGTGTGCAGAT
GCTGCTCATGGCCTCAAAGGCCACATCATTTCAGATGGAGGTTGCAGCTGCCCTGGGGATGTGG
CCAAAGCTTTTGGGGCAGGGGCTGACTTTGTGATGCTCGGTGGCATGCTGGCTGGGCACAGTGA
GTCAGGTGGTGAGCTCATCGAGAGGGATGGCAAGAAGTACAAACTCTTCTATGGAATGAGTTCT
GAAATGGCCATGAAGAAGGCCTCAGAGGGAAAGACAGTAGAAGTCCCCTTTAAAGGGGATGTGG
AGCATACCATTCGTGACATCCTAGGAGGGATCCGATCTACATGCACCTATGTGGGAGCAGCTAA
GCTAAAGGAGTTGAGCCGGAGAACTACTTTCATCCGAGTCACCCAGCAGGTGAATCTAATCTTC
AGTGATGCACACTAGACCTGAGCATTTCTGCCCGCTCAAGGCGCCAATACTTCGCAACAGGGTC
TCCCAAATGGGTTTCTCACCCATTCTAACTACTGTGGCAGTGCATTTAACAGTTCCCATTGTCT
TCCTCCTGAGAGCTCCTGTAATAATGTTATACTTCTCTGTTTGTACACACAAGATGCCCAGAGC
ACTTACTGGGGAGGAAGTGAGGAAGAATATAGTCTGAAAATGAAGTAAGATAATCGAATGGGTA
TCTGGGTACCCGGCATCCTGAAGATGAAAAGATACTGATTAAATCATAAATGTTCTATATGGCC
TTGGTCTGGATGGGGCAGGCTTTTGGAATTATGTCTTATTAATCAGCTTCATTAAATGAGATCT
TTAAATATCTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013219954	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002088.3
	ENSSTOP00000032641.1
GenBank Protein	KAG3260986	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013219954 ⟸ XM_013364500

- UniProtKB:

I3M079 (UniProtKB/TrEMBL), A0A287DGE3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQMYNGVPIIAANMDTVGTFEMA
KVLCKFSLFTAVHKHYSLHQWQEFAGQNPDCLQYLAASSGTGSSDFEQLEQILEAIPQVKYICL
DVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKT
GVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELI
ERDGKKYKLFYGMSSEMAMKKASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSR
RTTFIRVTQQVNLIFSDAH

hide sequence

Protein Domains

IMP dehydrogenase/GMP reductase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000002336	UniProtKB/TrEMBL
	ENSSTOG00000027180	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000002335.3	UniProtKB/TrEMBL
	ENSSTOT00000024388.2	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/TrEMBL
	GMPR	UniProtKB/TrEMBL
	IMP_DH/GMP_Rdtase_CS	UniProtKB/TrEMBL
	IMP_DH_GMPRt	UniProtKB/TrEMBL
NCBI Gene	Gmpr2	ENTREZGENE
PANTHER	GMP REDUCTASE	UniProtKB/TrEMBL
	GMP REDUCTASE 2	UniProtKB/TrEMBL
Pfam	IMPDH	UniProtKB/TrEMBL
PIRSF	GMP_reductase	UniProtKB/TrEMBL
PROSITE	IMP_DH_GMP_RED	UniProtKB/TrEMBL
SMART	IMPDH	UniProtKB/TrEMBL
Superfamily-SCOP	Inosine monophosphate dehydrogenase (IMPDH)	UniProtKB/TrEMBL
UniProt	A0A287DGE3	ENTREZGENE, UniProtKB/TrEMBL
	I3M079	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD