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Gene: CGREF1 (cell growth regulator with EF-hand domain 1) Chlorocebus sabaeus

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Symbol:

CGREF1

Name:

cell growth regulator with EF-hand domain 1

RGD ID:

18726269

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of cell growth (ortholog); ASSOCIATED WITH essential fructosuria (ortholog); Liver Neoplasms (ortholog); Tatton-Brown-Rahman syndrome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cell growth regulator with EF hand domain protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,500,056 - 80,516,893 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,513,701 - 80,516,698 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,622,380 - 31,639,353 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

essential fructosuria (ISO)

Liver Neoplasms (ISO)

Tatton-Brown-Rahman syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell growth (ISO)

Molecular Function

calcium ion binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

CGREF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,500,056 - 80,516,893 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,513,701 - 80,516,698 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,622,380 - 31,639,353 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CGREF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,099,353 - 27,119,128 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	27,098,889 - 27,119,128 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,322,221 - 27,341,996 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,176,973 - 27,195,475 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	27,235,119 - 27,253,622	NCBI
Celera	2	27,168,567 - 27,188,302 (-)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,064,526 - 27,084,159 (-)	NCBI		HuRef
CHM1_1	2	27,252,137 - 27,271,942 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,141,029 - 27,160,791 (-)	NCBI		T2T-CHM13v2.0

Cgref1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,090,487 - 31,102,771 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,090,487 - 31,102,935 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,933,143 - 30,945,480 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,933,143 - 30,945,591 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,235,516 - 31,247,853 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,209,724 - 31,222,166 (-)	NCBI		MGSCv36	mm8
Celera	5	28,412,941 - 28,425,273 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.9	NCBI

Cgref1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	31,151,795 - 31,163,801 (+)	NCBI		GRCr8
mRatBN7.2	6	25,431,846 - 25,443,853 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,431,799 - 25,443,852 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,732,163 - 25,744,167 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,048,027 - 26,060,031 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,527,201 - 25,539,214 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,797,126 - 26,809,132 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,797,126 - 26,809,129 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,612,741 - 36,624,747 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,414,812 - 25,426,818 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,417,842 - 25,429,770 (+)	NCBI
Celera	6	24,922,567 - 24,934,501 (+)	NCBI		Celera
RH 3.4 Map	6	119.2	RGD
Cytogenetic Map	6	q14	NCBI

Cgref1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	9,072,563 - 9,086,615 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	9,072,333 - 9,086,427 (-)	NCBI	ChiLan1.0	ChiLan1.0

CGREF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	99,396,407 - 99,415,823 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	99,400,376 - 99,419,791 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,098,387 - 27,118,129 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,189,151 - 27,207,263 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,188,352 - 27,199,407 (-)	Ensembl	panpan1.1		panPan2

CGREF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,093,664 - 21,106,797 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	20,985,489 - 20,998,849 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,414,345 - 21,427,720 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,413,017 - 21,427,705 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,101,095 - 21,114,500 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,112,197 - 21,125,293 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,159,031 - 21,161,865 (-)	NCBI		UU_Cfam_GSD_1.0

Cgref1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,395,880 - 65,410,272 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,429,131 - 5,442,965 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	5,429,397 - 5,444,219 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CGREF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	112,006,596 - 112,020,211 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	119,000,618 - 119,018,207 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Cgref1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	9,203,367 - 9,216,309 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	9,203,367 - 9,216,485 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007971178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038006690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007628 ⟹ ENSCSAP00000005804

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	80,513,701 - 80,516,698 (+)	Ensembl

RefSeq Acc Id:

XM_007971178 ⟹ XP_007969369

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	80,500,056 - 80,516,893 (+)	NCBI
Vero_WHO_p1.0	NW_023666045	31,622,380 - 31,639,344 (-)	NCBI

Sequence:

show sequence

CGCACACGCGCGCACTCACACGCACACGCGCGCCCGCAGCCCCTCCTGCTGCGGGCGCAGCAAG
GGCGCTGGAGGAGCTGTGAAGGGCCAGGTCTGGCGGGCGGGGCGGCGGCTGGCACTGGCTCCGG
ACTCTGCCCGGCCAGGGCGGCGACTCCAGCCGGGAGGGCGACGTGGAGCGGCCACGTGGAGCGG
CCCGGGGGAGGCTGGCGGCTGCAGGCGAGGCGCGGGCGGCGCAGCAGCCGGGAGCGCCCACGGA
GCTGGACTCCCAGCGCGGCGCGGCGCCACAACAGTTCCAGGAAGGATGTTACCTTTGATGATGA
GAGTGTTAATCCTGCTGCTGCTCCCCGTGGGTCAGGCTGCCCCAAAGGATGGAGTCACAAGGCC
AGACTCTGAAGTGCAGCATCAGCTCCTGCCCAACCCCTTCCAGCCAGGCCGGGAGCAACTCGGA
CTTCTGCAGAGCTACCTAAAGGGACTAGAAAGGACAGAAGTGCAGCCGGAGCATCTGAGCCGGG
AGCAGGTTCTCCTCTACCTCTTTGCCCTCCATGACTATGACCAGAGTGGACAGCTAGATGGCCT
GGAGCTGTTGTCCATGTTGACAGCTGCTCTGGCCCCTGGAGCTGCCAACTCTCCTACCACCAAC
CCGGTGATCTTGATAGTGGACAAAGTGCTCGAGACCCAGGACCTGAATAGGGATGGGCTCATGA
CCCCTGCTGAGCTCATCAACTTCCCGGGAGAGGCCCCCAGTCACGTGGAGCCCGGAGAGCCCCT
TGCTCCATCTCCTCAGGAGCCACAAGCTGTTGGGAGGCAGTCCCTGTTAGCTAAAAGCCCATTA
AGACAAGAAACACAGGAAGCCCCAGGTCCCAGAGAAGAAGCAAAGGGCCAGGTAGAGGCCAGAA
GGGAGTCTTTGGATCCTGTCCAAGAGCCTGGGGGCCAGGCAGAGGCTGAAGGAGACGTTCCAGG
GCCCAGAGGGGAAGCTGGGGGCCAGGCAGAGGCTGAAGGAGACGTTCCGGGGCCCAGAGGGGAA
GCTGGGGGCCAGGCAGAGGCCAGGGAGAATGGAGAGGAGGCCAAGGAACTTCCAGGGGAAACAC
TGGAGTCTAAGAACATCCCAAATGAGTTTGAGGTGCACATTGTTCAACTGGAGAATGATGAGAT
CTAGATCTCGAAGATACAGGTACCCCACGATGTCTCAGTTTCAGAACATAAGCCCTGAAGCGGG
CAGGGGAATGTACGCTGGGACAAGGACCACCTCTGTGCCCCCTGTCTGGTCCCAGTAGGTATCA
GGTCTTTCTGTGCAACTCAGGGAGACCCTAAGTTAAGGGGCAGATTGCCAATAAAGAACTGAAT
GAATTCA

hide sequence

RefSeq Acc Id:

XM_038006690 ⟹ XP_037862618

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666045	31,622,892 - 31,639,353 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007969369	(Get FASTA)	NCBI Sequence Viewer
	XP_037862618	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005804
	ENSCSAP00000005804.1

RefSeq Acc Id:	XP_007969369 ⟸ XM_007971178
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RB15 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000005804 ⟸ ENSCSAT00000007628

RefSeq Acc Id:	XP_037862618 ⟸ XM_038006690
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009550	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007628.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	ER-Golgi_Adhesion_Reg	UniProtKB/TrEMBL
KEGG Report	csab:103220616	UniProtKB/TrEMBL
NCBI Gene	CGREF1	ENTREZGENE
PANTHER	CELL GROWTH REGULATOR WITH EF HAND DOMAIN PROTEIN 1	UniProtKB/TrEMBL
	MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0D9RB15	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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