SERPINB12 (serpin family B member 12) - Rat Genome Database

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Gene: SERPINB12 (serpin family B member 12) Chlorocebus sabaeus
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Symbol: SERPINB12
Name: serpin family B member 12
RGD ID: 18683355
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN hematopoietic progenitor cell differentiation (inferred); ASSOCIATED WITH chromosome 18q deletion syndrome (ortholog); multiple congenital anomalies-hypotonia-seizures syndrome 1 (ortholog); FOUND IN cornified envelope (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serpin B12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,193,673 - 16,208,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1816,194,694 - 16,206,029 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,483,861 - 9,496,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SERPINB12Green Monkeychromosome 18q deletion syndrome  ISOSERPINB12 (Homo sapiens)8554872ClinVar Annotator: match by term: Monosomy 18q and deletion 18qClinVarPMID:25741868 and PMID:31690835
SERPINB12Green Monkeymultiple congenital anomalies-hypotonia-seizures syndrome 1  ISOSERPINB12 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple congenital anomalies-hypotonia-seizures syndrome 1ClinVarPMID:10677500 more ...


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SERPINB12Green Monkeyhematopoietic progenitor cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9D7P9 and ensembl:ENSMUSP00000080030150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SERPINB12Green Monkeycornified envelope is_active_inIEAUniProtKB:Q9D7P9 and ensembl:ENSMUSP00000080030150520179 EnsemblGO_REF:0000107
SERPINB12Green Monkeyextracellular space located_inIEAInterPro:IPR000215150520179 InterProGO_REF:0000002
SERPINB12Green Monkeyextracellular space located_inIEAPANTHER:PTN000156810150520179 TreeGrafterGO_REF:0000118

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SERPINB12Green Monkeyserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR000215150520179 InterProGO_REF:0000002
SERPINB12Green Monkeyserine-type endopeptidase inhibitor activity enablesIEAUniProtKB:Q96P63 and ensembl:ENSP00000372218150520179 EnsemblGO_REF:0000107
SERPINB12Green Monkeyserine-type endopeptidase inhibitor activity enablesIEAPANTHER:PTN000156810150520179 TreeGrafterGO_REF:0000118

PMID:30032202  



SERPINB12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,193,673 - 16,208,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1816,194,694 - 16,206,029 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,483,861 - 9,496,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SERPINB12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,519,110 - 63,569,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,542,369 - 63,569,329 (+)EnsemblGRCh38hg38GRCh38
GRCh371861,209,602 - 61,236,562 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361859,374,373 - 59,385,224 (+)NCBINCBI36Build 36hg18NCBI36
Build 341859,374,372 - 59,385,224NCBI
Celera1857,943,890 - 57,954,746 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,923,215 - 57,934,075 (+)NCBIHuRef
CHM1_11861,219,374 - 61,230,454 (+)NCBICHM1_1
T2T-CHM13v2.01863,724,229 - 63,774,441 (+)NCBIT2T-CHM13v2.0
Serpinb12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,862,179 - 106,884,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,862,179 - 106,884,810 (+)EnsemblGRCm39 Ensembl
GRCm381106,934,449 - 106,957,080 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,934,449 - 106,957,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371108,831,026 - 108,853,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,761,996 - 108,784,625 (+)NCBIMGSCv36mm8
Celera1109,783,814 - 109,805,887 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.34NCBI
Serpinb12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,567,023 - 23,598,329 (+)NCBIGRCr8
mRatBN7.21323,052,384 - 23,083,691 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,052,448 - 23,083,691 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,374,783 - 23,406,019 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,659,242 - 24,690,484 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,344,967 - 23,376,203 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,970,824 - 26,999,709 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,970,660 - 26,998,357 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,616,215 - 31,619,910 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01332,119,751 - 32,147,132 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,106,080 - 13,137,360 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1322,909,857 - 22,938,862 (+)NCBICelera
Cytogenetic Map13p11NCBI
Serpinb12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540247,342,151 - 47,360,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540247,338,874 - 47,361,485 (+)NCBIChiLan1.0ChiLan1.0
SERPINB12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21781,029,581 - 81,081,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11866,722,192 - 66,773,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01856,915,588 - 56,926,603 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11860,227,478 - 60,238,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1860,190,661 - 60,240,704 (+)Ensemblpanpan1.1panPan2
SERPINB12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,516,993 - 13,539,834 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,518,850 - 13,539,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,476,959 - 14,501,163 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,371,247 - 13,395,525 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,374,489 - 13,395,606 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,409,543 - 13,433,747 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,338,833 - 13,363,115 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,587,695 - 13,611,747 (-)NCBIUU_Cfam_GSD_1.0
Serpinb12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,773,996 - 26,791,578 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364972,014,871 - 2,024,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINB12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,120,868 - 158,143,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,120,724 - 158,143,085 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Serpinb12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247929,326,066 - 9,343,959 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247929,326,061 - 9,344,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in SERPINB12
371 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
12 7 17 17 17 12 7



Ensembl Acc Id: ENSCSAT00000016295   ⟹   ENSCSAP00000014214
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1816,194,694 - 16,206,029 (-)Ensembl
RefSeq Acc Id: XM_008013860   ⟹   XP_008012051
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11816,193,673 - 16,206,343 (-)NCBI
Vero_WHO_p1.0NW_0236660609,483,861 - 9,496,030 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037988047   ⟹   XP_037843975
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660609,483,861 - 9,496,030 (+)NCBI
Protein RefSeqs XP_008012051 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843975 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014214.1
RefSeq Acc Id: XP_008012051   ⟸   XM_008013860
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S025 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000014214   ⟸   ENSCSAT00000016295
RefSeq Acc Id: XP_037843975   ⟸   XM_037988047
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S025 (UniProtKB/TrEMBL)



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000018198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016295.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report csab:103244158 UniProtKB/TrEMBL
NCBI Gene SERPINB12 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  SERPIN B12 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A0D9S025 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows