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Gene: MAGEA3 (MAGE family member A3) Chlorocebus sabaeus

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Symbol:

MAGEA3

Name:

MAGE family member A3

RGD ID:

18675906

Description:

ENCODES a protein that exhibits caspase binding (ortholog); INVOLVED IN negative regulation of autophagy (ortholog); negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ortholog); negative regulation of protein processing (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal hemophilia A (ortholog); factor VIII deficiency (ortholog); FOUND IN endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103219333; LOC103232764; melanoma-associated antigen 3; melanoma-associated antigen 3-like

RGD Orthologs

Human

Mouse

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	127,271,604 - 127,276,373 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	65,122,165 - 65,125,813 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

autosomal hemophilia A (ISO)

factor VIII deficiency (ISO)

hepatocellular carcinoma (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of autophagy (ISO)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ISO)

negative regulation of protein processing (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

Cellular Component

endoplasmic reticulum (ISO)

nucleus (IEA)

Molecular Function

caspase binding (ISO)

histone deacetylase binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

MAGEA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	127,271,604 - 127,276,373 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	65,122,165 - 65,125,813 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MAGEA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	152,698,794 - 152,702,347 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	152,698,767 - 152,702,347 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	151,867,272 - 151,870,825 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	151,685,308 - 151,688,896 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	151,605,220 - 151,608,808	NCBI
Celera	X	152,112,403 - 152,115,991 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	140,736,139 - 140,739,870 (-)	NCBI		HuRef
CHM1_1	X	151,809,270 - 151,812,865 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	150,965,367 - 150,968,920 (+)	NCBI		T2T-CHM13v2.0

Magea3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	153,731,176 - 153,742,027 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	153,731,539 - 153,732,501 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	154,948,180 - 154,959,031 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	154,948,543 - 154,949,505 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	151,383,006 - 151,384,112 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	150,289,259 - 150,290,221 (-)	NCBI		MGSCv36	mm8
Celera	X	138,271,904 - 138,273,010 (-)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	72.38	NCBI

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

hemolymphoid system	mesenchyme	mesoderm
17	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007993012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007993013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007993014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037989293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037989294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007993014 ⟹ XP_007991205

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	X	127,271,604 - 127,276,373 (-)	NCBI
Vero_WHO_p1.0	NW_023666065	65,122,165 - 65,125,813 (+)	NCBI

Sequence:

show sequence

GACGTTGGGGAGGTTTGTAGCCTGCCTAGACGGCAGATGACAGAATGGGTGGAATAAAAGTTTT
TAAATTTCCACTTCACTTCATTGCACAGTCTGAGGCAGCCCCTGAAAGTACGATGCCAAGGGCC
TCGGGAAACAGCAGGACACCAGGAAAATTGGGTTGGTTAAGGCAGTATGGCTCCAGAGTTCTGC
TAACAACAACCTGAAACCAACACTGTGGGAGAGGAATTACGTTTTAAAAAAAATTATTTCAACA
GAACACAAAGACTGAAATAGAATAGGATATCAGAGTGAATTATGCATACTAAGGGTAGGTGTTA
GTTCATAGAAATATATATATGTGTGTGTGTGTATATATATATATATAGCTACCTACATATATAC
TTGTAAGATATGTAAACCCTATTTCTTTGATTCAGAGAATAAATCATTTGGTACCAAAAGTTTG
CCAAGTGTAACCCTGGCTGGGGAGGAGCCCCCGTGGGAAGGTGTGCGTCTTCTCCCAGAGGTCA
CTACAATCGCGGGGGCTGCCGCCCTGCAGGGAGCACCTGACCTGGGACCTGCAGCCATTCTTTA
CAAGGGGTGCAGCTGTGCAAATGCTCAGAGGTGACAGAAACAGAGCATCTCCTGCCCATCACTT
CATCCAACAGCCAGGGGTGAGGAAGAGGACCCTACTGAGTGAGGACTGAGGGTCCTCCCCCGCC
CCCCCCAACACACACATAGAGGGACCATAGAATCCAGCTCAGCCCCTCTTGTCAGCCCTGGTAA
ACGCAGGCAATGATGTCACCCCGAACACAGCCCTTCCCCCAATGCCACTTCGGGGGGACTCAGA
GACTTGGTCTGAGTGGAGCAGAAACCATTGGCAGATGATGGCGGTCCTGACTCAGCCAGGCATC
AACTTCAGGCCCCTGAGGGATGGCCGAAGCCTCCTCCCACCCCCAACTCCCCTGATCCCACTAG
GACATACAGCCTCAGGATCCCCATCCCAATCTCTACCCCTTCACCCATCACCATCTTCGTGCTC
ACCCCCATCCCCATCCAGATCCCCATCCAGGCCGAATCCAGTTCCACCCCTGCTGTGAACCCAG
GGAAGTACAGTTGCCCGGATGTGACGCCACTGACTTGCGCATTGGCGGTCAGACGGCGGCGAGA
TTCTCGCCCTGAGCAACGGCCTGATGTCGGCGGAGGGAAGCAGGCCCAGGCTTGGTGAGGAGGC
AAGGTTCTGAGGGGACAGGCTGACAAGGAGGACCAGAGGCCCCTGGAGGAGCACGGAAGGAGAA
GATCTGCCTGTGGGTTTCCATTGCCCAGCTCCTGCCCACACTCCCGCCTACTGCCCTGACCAGA
GTCAGCATGCCTCTTGAGCAGAGGAGTCAACACTACAAGCCTGAAGAAGGCCTTGAGGCCCGAG
GAGAGGCCCTGGGCTTGGTGGGTGCACAGGCTTCTGCTACTGAGGAGCAGGAGACTGCCTCCTC
CTCTTCTACTGTAGTGGAAGTCACCCTGGGGGAGGTGCCTGCTGCTGAGTCACCGGGTCCTCCC
CAGAGTCCTCAGGGAGCCTCCACCCTCCCCACTACCAACAACTACACACTCTGGAGCCAATTTG
ATGAGGACTCCAGCAACCAAGAAGAGGAGGGGCCAAGCACCTTTCCTGACCTGGAGTCCGGCTT
CCAGGCAGCACTCAGTAGGAAGGTGGCTGAGTTGGTTCATTTTCTGCTCCTCAAGTATCGAGTC
AGGGAGCCAGTCACAAAGGCAGAAATGCTGGGGAGTGTCATGAGAAATTGCCAGTACTTCTTTC
CTGTGATCTTCAGCAAAGCATCTGATTCCTTGCAGCTGGTCTTTGGCATCGAGCTGATGGAAGT
GGACCCAGTCGGCCACTTGTACATCCTTGTCACCTGCCTGGGCCTCTCCTACGATGGCCTGCTG
GGCGACAATCAGATCATGCCCAAGGCAGGCCTCCTGATAATCGTCCTGGCCATAATCGCAAAAG
AGGGCGACTGCGCCCCTGAGGAGAAAATCTGGGAGGAGCTGAATGTGTTGGAGGTGTTTGACGG
GAGGGAACACAGTATCTTCGCGGATCCCAGGAAGCTGCTCACCCAAGATTTCGTGCAGGAAAAC
TACCTGGATTACCGGCAGGTGCCTGGCAGTGATCCTGCATGCTACGAGTTCCTGTGGGGTCCAA
GGGCCCTCGTTGAAACCAGCTATGTGAAAGTCCTGTACCATATGCTAAAAATCAGTGGAGGACC
TCACTTTTCCTACCCACCCCTGCATGAATGGGCTTTGAGAGAGGGGGAAGAGTGAGTCCGAGCA
CACGTTGTAGCCAGGGCCAGTGGGAGGGGTCTGGGCCAGTGCACCTTCCAGGGCCCCATCCGTT
AGCTTCCACTGCCTTGTGTGACATGAGGCCCATTCTTCATTCACTCTTTGAAGAGAGCAGTCAG
CATTCTCAGTTTTGGGTTTCTGTTCTATTGGATGACTTGGAGATTTATCTTTGTTTCCTGTTGG
AATTGCTCAAATGTTCCTTTTAACAGGTGGTTGAATGAACTTCAGCATCCACGTTTGTGAATGA
CAGTAGTCACACATAGTGCTGTTTATATAGTTTAGGAGTAAAAGTCTTGTTTTTTATTCAGATT
GGGAAATCCATTCCATTTTGTGAATTGTGACGTAATTACAGCAGTGAAAAAGTATTTGCTTAAA
ATTGTGAGCGAATTAGCAATGACATACAAGGGATAAAGAACTCAAGACATTAAAAGATAGTTAA
TTCTTGCCTTATACCTCAGTCTATTCTGTAAAATTAAATAAATATGCATACCTGGATTTCCTGG
GCTTCTTTGAGAATGCAAGTGAAATTAAATCTGAATAAATAATTCTTTCTGTT

hide sequence

RefSeq Acc Id:

XM_037989293 ⟹ XP_037845221

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666065	65,122,177 - 65,125,801 (+)	NCBI

RefSeq Acc Id:

XM_037989294 ⟹ XP_037845222

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666065	65,122,165 - 65,125,813 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007991205	(Get FASTA)	NCBI Sequence Viewer
	XP_037845221	(Get FASTA)	NCBI Sequence Viewer
	XP_037845222	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017477.1

RefSeq Acc Id:	XP_007991205 ⟸ XM_007993014
- UniProtKB:	A0A0D9S9D8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037845222 ⟸ XM_037989294
- UniProtKB:	A0A0D9S9D8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037845221 ⟸ XM_037989293
- UniProtKB:	A0A0D9S9D8 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000527	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000018008.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.1200	UniProtKB/TrEMBL
	1.10.10.1210	UniProtKB/TrEMBL
InterPro	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
	MAGE_WH1	UniProtKB/TrEMBL
	MAGE_WH2	UniProtKB/TrEMBL
	MHD_dom	UniProtKB/TrEMBL
KEGG Report	csab:103232764	UniProtKB/TrEMBL
NCBI Gene	LOC103232764	ENTREZGENE
PANTHER	PTHR11736	UniProtKB/TrEMBL
	PTHR11736:SF60	UniProtKB/TrEMBL
Pfam	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
PROSITE	MAGE	UniProtKB/TrEMBL
SMART	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
UniProt	A0A0D9S9D8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	MAGEA3	MAGE family member A3	LOC103232764	melanoma-associated antigen 3	Symbol and/or name change	5135510	APPROVED
2020-12-03	LOC103232764	melanoma-associated antigen 3	LOC103219333	melanoma-associated antigen 3-like	Data merged from RGD:18716248	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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