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Gene: KLF17 (KLF transcription factor 17) Chlorocebus sabaeus

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Symbol:

KLF17

Name:

KLF transcription factor 17

RGD ID:

18645041

Description:

ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN gamete generation (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Krueppel-like factor 17; Kruppel like factor 17

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	88,651,224 - 88,666,423 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	88,654,702 - 88,665,822 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	28,252,756 - 28,267,778 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

gamete generation (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IEA)

Molecular Function

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

KLF17
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	88,651,224 - 88,666,423 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	88,654,702 - 88,665,822 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	28,252,756 - 28,267,778 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

KLF17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	44,043,927 - 44,135,140 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	44,118,821 - 44,135,140 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	44,584,493 - 44,600,812 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	44,357,109 - 44,373,399 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	44,253,614 - 44,269,900	NCBI
Celera	1	42,868,030 - 42,884,304 (+)	NCBI		Celera
Cytogenetic Map	1	p34.1	NCBI
HuRef	1	42,699,331 - 42,715,631 (+)	NCBI		HuRef
CHM1_1	1	44,700,581 - 44,716,865 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	43,915,021 - 44,006,090 (+)	NCBI		T2T-CHM13v2.0

Klf17
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	117,613,856 - 117,622,863 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	117,615,033 - 117,622,845 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	117,756,659 - 117,765,666 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	117,757,836 - 117,765,648 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	117,429,264 - 117,438,271 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	117,254,591 - 117,263,598 (-)	NCBI		MGSCv36	mm8
Celera	4	112,741,336 - 112,742,651 (-)	ENTREZGENE		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.46	NCBI

Klf17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	136,578,594 - 136,601,234 (-)	NCBI		GRCr8
mRatBN7.2	5	131,293,068 - 131,315,878 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	131,307,476 - 131,315,084 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	136,602,472 - 136,610,058 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	136,602,395 - 136,610,054 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	140,375,706 - 140,399,709 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	138,234,501 - 138,241,255 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	138,239,726 - 138,246,481 (-)	NCBI
Celera	5	129,856,540 - 129,864,126 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Klf17
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955537	3,637,825 - 3,648,078 (+)	NCBI	ChiLan1.0	ChiLan1.0

KLF17
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	182,673,849 - 182,691,665 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	181,815,268 - 181,833,054 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	43,419,910 - 43,435,499 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	44,721,612 - 44,807,348 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	44,791,190 - 44,802,965 (+)	Ensembl	panpan1.1		panPan2

KLF17
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	16,147,898 - 16,160,548 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	16,148,857 - 16,160,462 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	16,260,803 - 16,282,609 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	16,293,799 - 16,315,624 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	16,302,886 - 16,315,660 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	16,101,720 - 16,114,440 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	16,161,011 - 16,182,817 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	16,234,139 - 16,255,955 (-)	NCBI		UU_Cfam_GSD_1.0

Klf17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	59,589,209 - 59,598,337 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	25,413,907 - 25,422,643 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLF17
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	167,176,834 - 167,188,418 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	167,176,834 - 167,188,418 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	154,739,301 - 154,775,750 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Klf17
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624892	3,374,538 - 3,383,943 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624892	3,374,594 - 3,383,928 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in KLF17
327 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
10	10	20	27	27	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007979020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017337 ⟹ ENSCSAP00000016818

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	88,654,702 - 88,665,822 (-)	Ensembl

RefSeq Acc Id:

XM_007979020 ⟹ XP_007977211

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	88,651,224 - 88,666,423 (-)	NCBI
Vero_WHO_p1.0	NW_023666033	28,252,756 - 28,267,778 (+)	NCBI

Sequence:

show sequence

CCCCTAGTTCAGAGATCAATGCCCAACACACACTGGGCACTCAGTAAACACTGTGGAATAAATA
GATTGTGCCGTGAAGCTCCCAGTCTTCAGTTCGTACGGACAAGGGACAGAGGTGCACAGACATT
AGCAGAAAAGCTCCAGCCCTCCCAAAGCTTATGGCAAGCTCCCGACCTGATAGAGTGCTGGTGG
AGGCTCTCCTGTCGGCAGACGCCCTACACCCAGCCTTGCCTCTCTCTCCAGCCTCCTCCTAGCT
GGAGTCTGAGACCTGGGGATCCTCAGCCCCTACTTGGGTGAAACAGTTGCTCAGACTGAAGGGT
GGAATGTGTGGGTTGGGTGGGCGGACCAACTTCCTTTAGGAAGCGTTCAAGGCCTGAGGTGGCT
GTCCGTGATGCGCCTTGGTTGGGGTGGGCAGCCTAGGGCAGGGCTGCAGGGGCGGCGCAGGGCG
GGAAGGGTGGGGCTGACTCCGCCCCCTGGCGCAGCTGTAAATAGGTAAATAGAAGGTGATTGTG
GCGTGGCGATGTCCCGATACCCGCCTGCGACGCCGTGGTGGCTGGTTTCCTGTCCGTTCAGTAG
AGAGTCTAGACCCCACCCAGTCTTCATGTACAACCGACCGCAGGCTGAGATGGAACAGGAGGCT
GGGGAGCTGAGCCGATGGCAGGTGGCGCACCAGGCTGCCCAGGATAACGAGAACTCAGCGCCCA
TCTTGAACATGTCTTCATCTTCTGGAAGCTCTGGAGTGCACACCTCTTGGAACCAAGGCCTACC
AAACATTCAGCACTTTCCTCACAGTACAGAGATGCTGAGGTCCCCCTTGGTGTCTGTTGAGGCA
CCGGGGCAGAATATGGATGAAGGAGGGCCACAGTTCAGTATGCCACTGCCTGAGCGTGGTGTGA
GCTACTGCCCCCAAGCGACTCTCACTCCTTCCCAGATGATTTACTGTCAGAGAGTGTCTCCCCC
TCAGCAAGAGATGATGATTTTCAGTGGGCCCCAACTAATGCCCATAGGACAGCCCAATATTCCA
AGGGTGGCCAGGCCCTTCAGCGGGAATCTAAGGATGCCCCCCAATGGGCTGCCAGTCTCGGCTT
CCACTGGAATCCCAATGATGTCCCACGCTGGGAACCCTCCAATGCCTTACCCTGGCCTCTCGAC
AGTGCCTTCTGAAGAAACATTGTTAGGCCCGACCATGCCTTCCACTGAGGCCCAGGCAGTGCTC
CCATCCATGGCTCAGATGTTGCCCCCACAAGATGCCCATGACCTTGGGATGCCTCCAGCTGAGC
CCCAGTCATTGCTGGCTTTAGGGTCTCAGGACTCTCTTGTGACTCAGCCGGACTCTCAAGAAGA
CCCATTTCTACCAGAGCAGCCCAGACCTGCTCCACAGACAGCAGAGAAGAACTCCAGGCCTCGG
GAAAGGACTGGTAGAGGGGGCTCCTCGGAGGCAAGGCCTTACTGCTGCAACTACGAGAACTGCG
GAAAAGCTTATACCAAACGCTCCCACCTGGTGAGCCACCAGCGCAAGCACACAGGTGAGAGGCC
CTATTCTTGCAACTGGGAAAGTTGTTCATGGTCTTTCTTCCGTTCTGATGAGCTGAGACGACAT
ACACGGGTTCACACCAGATATCGACCATATAAATGTGATCAGTGCAACCGGGAGTTCATGAGGT
CTGACCATCTCAAGCAACACAAGAAAACTCATCGGCCAGGACCCTCAGACCCACAGACCAACAA
TAGAGAGCAGGACGGTCCTCCTGCTGCTGGTCCTTAGGTGAATGAAGAAGGAAGAGGATTCCAG
GCAGAGAACACTGGACGTGGCAACTGCTCAGAGGAGAGGCAGTCTTCAAGTTCTGCATTCATTC
AGCAAATGTTTCTTGAGCCTACAATACTGAGCGCACCAAGGCTGTGAAGACCCATGGTGAGGAG
CATGAAGTTAACTAAAGGATGTGTCAGAGAAAGACTTCTCAAGGAGATGCCTCCATGAGACCCG
AAGGACTCATGGGTGCTAGTTGCACCTCCCATTTCTTGGACATATACCGTTGGACATGTCTATC
TTCTGGAAACTATGGCATGGACAGTAAGGATTCAGAGGTGCATGAAGGCACCCTGCCTCTGCAG
AGCAGAAAGATCACAGACAACATTTATGAATGTACCCAGTGTTGCCAAGAAGAGAAGCTGGTCC
TCTGCAGGTTCAAGCCTATCTGGGCCTCTGGGGAAGCCCCACAACCTTGGCTGTGCCTGCGCCT
GCCCTCCCACCCCTGCCCTGACCCTGTCCTGCTTTGCTGCCTTTGTCCGTGTTACTAGTGGCCC
CAGTATACCTGGGATGGACATCTAGGTGCCCTTCATCCAAGCTCCCACGTGAGGGGAGTGGACA
TGATTAAAAGAACAGGGGCAGAAGGGGCTCATTTATGACCCATTCCCTAGCCCCAGGGATTGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007977211	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000016818.1

RefSeq Acc Id:	XP_007977211 ⟸ XM_007979020
- UniProtKB:	A0A0D9S7H9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000016818 ⟸ ENSCSAT00000017337

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000001196	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017337.1	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	KLF17	ENTREZGENE
PANTHER	KRUEPPEL-LIKE FACTOR 17	UniProtKB/TrEMBL
	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A0D9S7H9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-07-12	KLF17	KLF transcription factor 17	KLF17	Kruppel like factor 17	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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