MPP2 (MAGUK p55 scaffold protein 2) - Rat Genome Database

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Gene: MPP2 (MAGUK p55 scaffold protein 2) Chlorocebus sabaeus
Analyze
Symbol: MPP2
Name: MAGUK p55 scaffold protein 2
RGD ID: 18626489
Description: ENCODES a protein that exhibits PDZ domain binding (ortholog); INVOLVED IN protein homooligomerization (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cytoskeleton (ortholog); glutamatergic synapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAGUK p55 subfamily member 2; membrane palmitoylated protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,487,176 - 62,519,874 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,487,453 - 62,517,413 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,261,366 - 33,294,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,487,176 - 62,519,874 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,487,453 - 62,517,413 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,261,366 - 33,294,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,875,360 - 43,909,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,875,357 - 43,909,711 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,952,728 - 41,987,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,308,253 - 39,340,639 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,308,252 - 39,340,639NCBI
Celera1738,660,767 - 38,693,150 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,716,788 - 37,751,379 (-)NCBIHuRef
CHM1_11742,188,320 - 42,222,639 (-)NCBICHM1_1
T2T-CHM13v2.01744,727,944 - 44,762,256 (-)NCBIT2T-CHM13v2.0
Mpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,947,841 - 101,979,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,947,841 - 101,979,341 (-)EnsemblGRCm39 Ensembl
GRCm3811102,057,015 - 102,088,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,057,015 - 102,088,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,918,331 - 101,949,829 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,873,109 - 101,904,592 (-)NCBIMGSCv36mm8
Celera11113,762,219 - 113,794,313 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Mpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,511,638 - 87,544,710 (-)NCBIGRCr8
mRatBN7.21087,011,434 - 87,043,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,011,434 - 87,043,896 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,042,631 - 92,073,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,514,685 - 91,545,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,907,996 - 86,938,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,998,284 - 90,030,766 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,999,917 - 90,030,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,787,735 - 89,819,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,125,953 - 91,156,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,144,644 - 91,168,093 (-)NCBI
Celera1085,731,908 - 85,761,512 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Mpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,132,181 - 17,144,521 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,130,265 - 17,144,626 (-)NCBIChiLan1.0ChiLan1.0
MPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,988,640 - 21,030,648 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,942,870 - 22,994,935 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,487,459 - 13,519,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,653,155 - 13,685,751 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,651,433 - 13,685,752 (+)Ensemblpanpan1.1panPan2
MPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,411,796 - 19,440,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,413,619 - 19,438,909 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,801,600 - 18,830,160 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,107,180 - 20,135,794 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,106,929 - 20,136,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,960,167 - 18,988,743 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,149,762 - 19,171,973 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,288,295 - 19,316,904 (+)NCBIUU_Cfam_GSD_1.0
Mpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,747,927 - 18,773,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541418,499 - 446,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541420,546 - 446,671 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,239,668 - 19,268,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,239,557 - 19,268,013 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,498,903 - 19,506,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795915,814 - 937,982 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795915,245 - 936,191 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MPP2
636 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000001500   ⟹   ENSCSAP00000014578
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1662,487,453 - 62,517,413 (+)Ensembl
RefSeq Acc Id: XM_008012492   ⟹   XP_008010683
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11662,493,882 - 62,519,874 (+)NCBI
Vero_WHO_p1.0NW_02366607733,268,265 - 33,294,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008012493   ⟹   XP_008010684
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11662,487,176 - 62,519,874 (+)NCBI
Vero_WHO_p1.0NW_02366607733,261,366 - 33,294,344 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008012494   ⟹   XP_008010685
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11662,487,662 - 62,519,874 (+)NCBI
Vero_WHO_p1.0NW_02366607733,262,111 - 33,293,539 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008010683 (Get FASTA)   NCBI Sequence Viewer  
  XP_008010684 (Get FASTA)   NCBI Sequence Viewer  
  XP_008010685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014578
  ENSCSAP00000014578.1
RefSeq Acc Id: XP_008010684   ⟸   XM_008012493
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S139 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008010685   ⟸   XM_008012494
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S139 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008010683   ⟸   XM_008012492
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCSAP00000014578   ⟸   ENSCSAT00000001500


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001500.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  L27 domain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro GK/Ca_channel_bsu UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/TrEMBL
  L27_C UniProtKB/TrEMBL
  L27_dom UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/TrEMBL
  MAGUK UniProtKB/TrEMBL
  MPP2_SH3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene MPP2 ENTREZGENE
PANTHER MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_1 UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
  L27 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9S139 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-21 MPP2  MAGUK p55 scaffold protein 2  MPP2  membrane palmitoylated protein 2  Symbol and/or name change 5135510 APPROVED