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Gene: PTP4A3 (protein tyrosine phosphatase 4A3) Chlorocebus sabaeus

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Symbol:

PTP4A3

Name:

protein tyrosine phosphatase 4A3

RGD ID:

18584386

Description:

INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); endothelial cell migration (ortholog); Notch signaling pathway (ortholog); ASSOCIATED WITH Colonic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

basic salivary proline-rich protein 4-like; LOC103237514; protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	135,663,128 - 135,672,523 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	135,663,149 - 135,671,300 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	4,456,641 - 4,500,393 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colonic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (IEA,ISO)

endothelial cell migration (IEA,ISO)

Notch signaling pathway (IEA,ISO)

positive regulation of establishment of protein localization (IEA)

positive regulation of non-canonical NF-kappaB signal transduction (IEA)

positive regulation of vascular permeability (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of vascular endothelial growth factor signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PTP4A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	135,663,128 - 135,672,523 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	135,663,149 - 135,671,300 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	4,456,641 - 4,500,393 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PTP4A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	141,392,021 - 141,432,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	141,391,995 - 141,432,454 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	142,402,121 - 142,442,554 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	142,501,189 - 142,510,802 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	142,501,188 - 142,510,802	NCBI
Celera	8	138,607,734 - 138,608,044 (+)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	137,748,484 - 137,759,930 (+)	NCBI		HuRef
CHM1_1	8	142,471,719 - 142,482,782 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	142,513,520 - 142,559,812 (+)	NCBI		T2T-CHM13v2.0

Ptp4a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	73,594,991 - 73,629,075 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	73,594,994 - 73,630,615 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	73,723,145 - 73,758,766 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	73,723,145 - 73,758,766 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	73,553,575 - 73,589,196 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	73,575,667 - 73,586,021 (+)	NCBI		MGSCv36	mm8
Celera	15	75,228,105 - 75,263,862 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	34.05	NCBI

Ptp4a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	107,518,220 - 107,549,949 (+)	NCBI		GRCr8
mRatBN7.2	7	105,650,640 - 105,660,921 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	105,628,029 - 105,660,919 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	107,413,296 - 107,419,095 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	109,634,779 - 109,640,578 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	109,582,889 - 109,588,687 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	114,969,699 - 115,002,902 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	114,997,103 - 115,002,902 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	114,892,674 - 114,924,154 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	111,462,191 - 111,468,045 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	111,467,866 - 111,502,275 (+)	NCBI
Celera	7	102,062,262 - 102,068,065 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Ptp4a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	429,792 - 441,268 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	429,051 - 440,328 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTP4A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	158,783,895 - 158,830,201 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	134,314,474 - 134,360,646 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	138,062,418 - 138,108,281 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	141,166,898 - 141,187,383 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	141,166,898 - 141,188,314 (+)	Ensembl	panpan1.1		panPan2

PTP4A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	35,875,467 - 35,886,330 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	35,880,005 - 35,886,324 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	35,734,643 - 35,745,436 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	36,261,162 - 36,271,948 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	36,262,778 - 36,273,628 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	35,981,264 - 35,992,052 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	36,071,127 - 36,081,934 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	36,491,590 - 36,502,389 (+)	NCBI		UU_Cfam_GSD_1.0

Ptp4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	2,616,806 - 2,626,450 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	10,042,906 - 10,052,480 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	10,042,903 - 10,052,475 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTP4A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	2,345,118 - 2,364,672 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	2,345,119 - 2,376,765 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Ptp4a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	14,964,014 - 15,000,477 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	14,964,403 - 14,977,441 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008001653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038000088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007609 ⟹ ENSCSAP00000005784

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	135,663,149 - 135,671,300 (+)	Ensembl

RefSeq Acc Id:

XM_008001653 ⟹ XP_007999844

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	135,663,128 - 135,672,523 (+)	NCBI
Vero_WHO_p1.0	NW_023666039	4,456,641 - 4,470,976 (-)	NCBI

Sequence:

show sequence

CCGGGCCTGTTGGGAGGCGCCATGGCTCGGATGAACCGCCCAGCCCCGGTGGAGGTGAGCTACA
AACACATGCGCTTCCTCATCACCCACAACCCCACCAACGCCACGCTCAGCACCTTCATCGAGGA
CCTGAAGAAGTATGGGGCCACCACCGTGGTGCGCGTGTGTGAAGTGACCTATGACAAAACGCCG
CTGGAGAAGGATGGCATCACAGTTGTGGACTGGCCGTTTGACGACGGGGCGCCCCCGCCCGGCC
AGGTAGTGGAAGACTGGCTGAGCCTGGTGAAGGCCAAGTTCTGTGAGGCCCCCGGCAGCTGCGT
GGCTGTGCACTGCGTGGCGGGCCTGGGCCGGGCTCCAGTCCTTGTGGCGCTGGCCCTCATCGAG
AGTGGGATGAAGTACGAGGACGCCATCCAGTTCATCCGCCAGAAGCGCCGTGGAGCCATCAACA
GCAAGCAGCTCACCTATCTGGAGAAATACCGGCCCAAACAGAGGCTGCGTTTCAAAGACCCACA
CACGCACAAGACCCGGTGCTGTGTCATGTAGCTCAGGACCTTGACCGGGCCTGGTGGCCCTGCC
CAGCCCTGCTCTGCCCAGCCCAGCAGGGGCTCCAGGCCTTGGCTGGCCCCACATCGCCTTTTCC
TCCCCGACGCCTCCGTGCACTTGTGTCTGAGGAGCCCCCTGGCCCGTGTGGCCTCCGGGCCTTC
TCCTGCCTCTGCCGCTCCCTCTGGCAGCGCTGGCCGTGGCTCTGTCTTTCCGAGGTGGGTCGGG
CGCCCTCTTCCCGGGACCCCCGCCCACCCCTCCCACACCAGCCCAGGCCGGTCTCCTCTGGCCT
GTTTGTTCAGGGCGGGGGTACATTTTGTAACCACTGGGCCCCCCCAGCCCGTCTTCTGCGACCC
CTTGCCCTGACCTGTTCTCGGCACCTTAAATTATTAGACCCCAGGGCAGTCAGGTGTTCTGGAC
ACTCGAAGGCAATAAATCAGGAGCCGTGGCATGGCCGTGTGTGTGTGGAGTGGGCTGAGGCCTC
AGGCGGGGCGGGCCGCTGGCCTGGGGGCCCCCGGAGGGCTCGGGAGGCCACTGTCGGGATGCTG
GGCAGCTGCCCAGAATGGGGCTCCCGTGTGCTCCTACGCTGCCCTCTGGTGGCCGCTCTGGGTC
CCTGCACCCCGACCCAGGGGCCGGCCTGCCTTGTCTTGAAACCCAGGCGGGAGCCCTGCTTTGG
ACTGGGTGGCCATGTTGACGGTTCTCGGGACTGTGACATTAGAAGGCGAGGTGGGTCACCAGCA
TTGTCCTCTGCAGGATGGGCTGGGATTCATTTGGCAGTTCCTCAGGGCCTGTGTCCGGCGGGTT
GGTCCCTGTCCTGCCCCAACCAGGTGTCCACATTTCAGGCTCCGAGGCGCAGAGAAGGGTGCAG
GTGGTGGCTCAGGTGGAGGAAGGCTCCATCCATCAGCCCGGGGAGGGAGGGTACCTCCTGGGCA
CCTGGGGCTGGATGTGAGAGGCCTGGACCGGGGCCTGCTGGAGGGCGTGGACTGGATGCTCATG
TGTTCCTGGGTGCTGTGTCTGTGTTGGTGGCTGGCCCCACCCTAGGCCAGGGTGCACGGAGGGC
ATGGGAGGCCAGGGTGCACGGAGGGCATGGGAGGCCAGGGTGCACAGAGGGCATGGCCCCGCTG
GGAGGAAGGTGGGCCTGGGGCTGGCCCCAGGATTTGGAGACCTAGGAGTGGTCTCTGTCCTGGG
GCCCCAGGAGGTTCCAGCAAGAAGCAATTGGGGCAGGTCTGGAGGAGGTCAGTGGATAAGATGG
GGAGATGTGGAAACCCCAAAAGCCCTTTCTCAAGCAGCCCTGCCTCCAAGACTGACACACGGCT
AAGGGGGCCACAGACCTGGCTCCCCCAACTCCTGTGTAGAGAAAGGGCAACACCTCTCCCGGAT
GGTTACTCTCTCCTCAAACACATTTGGAACTCAAGTAAATCCGATGCGTGTTGGGTGAA

hide sequence

RefSeq Acc Id:

XM_038000088 ⟹ XP_037856016

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666039	4,456,641 - 4,500,393 (-)	NCBI

RefSeq Acc Id:

XM_038000089 ⟹ XP_037856017

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666039	4,456,641 - 4,476,852 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007999844	(Get FASTA)	NCBI Sequence Viewer
	XP_037856016	(Get FASTA)	NCBI Sequence Viewer
	XP_037856017	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005784
	ENSCSAP00000005784.1

RefSeq Acc Id:	XP_007999844 ⟸ XM_008001653
- UniProtKB:	A0A0D9RAZ5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000005784 ⟸ ENSCSAT00000007609

RefSeq Acc Id:	XP_037856016 ⟸ XM_038000088
- UniProtKB:	A0A0D9RAZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037856017 ⟸ XM_038000089
- UniProtKB:	A0A0D9RAZ5 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009539	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007609.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/TrEMBL
InterPro	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	PTP	UniProtKB/TrEMBL
	Tyr_Pase_cat	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/TrEMBL
KEGG Report	csab:103237513	UniProtKB/TrEMBL
NCBI Gene	PTP4A3	ENTREZGENE
PANTHER	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 3	UniProtKB/TrEMBL
	TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
Pfam	Tc-R-P	UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
SMART	PTPc_motif	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/TrEMBL
UniProt	A0A0D9RAZ5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-03	PTP4A3	protein tyrosine phosphatase 4A3	LOC103237514	basic salivary proline-rich protein 4-like	Data merged from RGD:18554682	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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