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Gene: PTP4A3 (protein tyrosine phosphatase 4A3) Homo sapiens
Symbol: PTP4A3
Name: protein tyrosine phosphatase 4A3
Description: Predicted to have protein tyrosine phosphatase activity. Involved in several processes, including endothelial cell migration; positive regulation of NIK/NF-kappaB signaling; and positive regulation of establishment of protein localization. Localizes to the cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: phosphatase of regenerating liver 3; potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; PRL3; protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; protein-tyrosine phosphatase of regenerating liver 3
Mus musculus (house mouse) : Ptp4a3 (protein tyrosine phosphatase 4a3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptp4a3 (protein tyrosine phosphatase 4A3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptp4a3 (protein tyrosine phosphatase 4A3)
Pan paniscus (bonobo/pygmy chimpanzee) : PTP4A3 (protein tyrosine phosphatase 4A3)
Canis lupus familiaris (dog) : PTP4A3 (protein tyrosine phosphatase 4A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptp4a3 (protein tyrosine phosphatase 4A3)
Sus scrofa (pig) : PTP4A3 (protein tyrosine phosphatase 4A3)
Chlorocebus sabaeus (African green monkey) : PTP4A3 (protein tyrosine phosphatase 4A3)
Heterocephalus glaber (naked mole-rat) : Ptp4a3 (protein tyrosine phosphatase 4A3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8141,391,995 - 141,432,454 (+)Ensembl
GRCh38 Ensembl8141,391,993 - 141,432,454 (+)Ensembl
GRCh388141,391,995 - 141,432,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378142,402,093 - 142,442,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,501,189 - 142,510,802 (+)NCBINCBI36hg18NCBI36
Build 348142,501,188 - 142,510,802NCBI
Celera8138,607,734 - 138,608,044 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8137,748,484 - 137,759,930 (+)NCBIHuRef
CHM1_18142,471,719 - 142,482,782 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTP4A3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318604
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.