PTP4A3 (protein tyrosine phosphatase 4A3) - Rat Genome Database

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Gene: PTP4A3 (protein tyrosine phosphatase 4A3) Homo sapiens
Analyze
Symbol: PTP4A3
Name: protein tyrosine phosphatase 4A3
RGD ID: 1318604
HGNC Page HGNC
Description: Predicted to have protein tyrosine phosphatase activity. Involved in several processes, including endothelial cell migration; positive regulation of NIK/NF-kappaB signaling; and positive regulation of establishment of protein localization. Localizes to cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: phosphatase of regenerating liver 3; potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; PRL3; protein tyrosine phosphatase type IVA 3; protein-tyrosine phosphatase 4a3; protein-tyrosine phosphatase of regenerating liver 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8141,391,993 - 141,432,454 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8141,391,995 - 141,432,454 (+)EnsemblGRCh38hg38GRCh38
GRCh388141,391,995 - 141,432,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378142,402,121 - 142,442,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,501,189 - 142,510,802 (+)NCBINCBI36hg18NCBI36
Build 348142,501,188 - 142,510,802NCBI
Celera8138,607,734 - 138,608,044 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8137,748,484 - 137,759,930 (+)NCBIHuRef
CHM1_18142,471,719 - 142,482,782 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9514946   PMID:9633825   PMID:10747914   PMID:11355880   PMID:11598267   PMID:12107411   PMID:12235145   PMID:12477932   PMID:12516958   PMID:12782572   PMID:14654542   PMID:14704153  
PMID:15135076   PMID:15161639   PMID:15489334   PMID:15534108   PMID:15788667   PMID:16203771   PMID:16472776   PMID:16505094   PMID:16832410   PMID:16873432   PMID:17018620   PMID:17235563  
PMID:17353931   PMID:17440740   PMID:17545014   PMID:17545077   PMID:17717498   PMID:17934070   PMID:18021371   PMID:18078820   PMID:18268019   PMID:18561324   PMID:18636172   PMID:18684031  
PMID:18803057   PMID:18813812   PMID:19002188   PMID:19009246   PMID:19040419   PMID:19087692   PMID:19101992   PMID:19115206   PMID:19132388   PMID:19152186   PMID:19187591   PMID:19214221  
PMID:19236507   PMID:19322201   PMID:19322925   PMID:19424625   PMID:19440036   PMID:19586538   PMID:19757198   PMID:19846928   PMID:19930715   PMID:19945467   PMID:20045518   PMID:20140626  
PMID:20364335   PMID:20516731   PMID:20609352   PMID:20806969   PMID:20860603   PMID:21084277   PMID:21135111   PMID:21159255   PMID:21291404   PMID:21320469   PMID:21466710   PMID:21478108  
PMID:21589872   PMID:21725609   PMID:21790231   PMID:21806020   PMID:21873635   PMID:21914394   PMID:22028901   PMID:22073279   PMID:22131018   PMID:22137788   PMID:22261620   PMID:22331511  
PMID:22340241   PMID:22345654   PMID:22413991   PMID:22440248   PMID:22469786   PMID:22595524   PMID:22677902   PMID:22825514   PMID:22855168   PMID:22995644   PMID:23036709   PMID:23092334  
PMID:23178297   PMID:23362275   PMID:23364316   PMID:23418787   PMID:23462371   PMID:23572150   PMID:23691193   PMID:23729584   PMID:23867504   PMID:23929599   PMID:23989302   PMID:24030100  
PMID:24204707   PMID:24403062   PMID:24632616   PMID:24686170   PMID:24696260   PMID:24737397   PMID:24885636   PMID:25136802   PMID:25139404   PMID:25475733   PMID:25687758   PMID:26041460  
PMID:26070892   PMID:26433386   PMID:26548949   PMID:26563151   PMID:26597054   PMID:26669864   PMID:26846972   PMID:26874360   PMID:26967563   PMID:26975394   PMID:27036022   PMID:27096756  
PMID:27229929   PMID:27328425   PMID:27432908   PMID:27452906   PMID:27572739   PMID:27656108   PMID:27698077   PMID:27880917   PMID:27911713   PMID:28063378   PMID:28068414   PMID:28246390  
PMID:28284838   PMID:28319085   PMID:28330616   PMID:28482095   PMID:28514442   PMID:28675297   PMID:28791350   PMID:28980126   PMID:29190795   PMID:29207031   PMID:29556339   PMID:30305722  
PMID:30418964   PMID:30498084   PMID:30816227   PMID:31171773   PMID:31298325   PMID:31337650   PMID:31546234   PMID:32413665   PMID:32571875   PMID:32606318   PMID:32616539   PMID:32652076  
PMID:32918875   PMID:33179291  


Genomics

Comparative Map Data
PTP4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8141,391,993 - 141,432,454 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8141,391,995 - 141,432,454 (+)EnsemblGRCh38hg38GRCh38
GRCh388141,391,995 - 141,432,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378142,402,121 - 142,442,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,501,189 - 142,510,802 (+)NCBINCBI36hg18NCBI36
Build 348142,501,188 - 142,510,802NCBI
Celera8138,607,734 - 138,608,044 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8137,748,484 - 137,759,930 (+)NCBIHuRef
CHM1_18142,471,719 - 142,482,782 (+)NCBICHM1_1
Ptp4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391573,594,994 - 73,630,615 (+)NCBIGRCm39mm39
GRCm39 Ensembl1573,594,994 - 73,630,615 (+)Ensembl
GRCm381573,723,145 - 73,758,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,723,145 - 73,758,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv371573,553,575 - 73,589,196 (+)NCBIGRCm37mm9NCBIm37
MGSCv361573,575,667 - 73,586,021 (+)NCBImm8
Celera1575,228,105 - 75,263,862 (+)NCBICelera
Cytogenetic Map15D3NCBI
Ptp4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27105,650,640 - 105,660,921 (+)NCBI
Rnor_6.0 Ensembl7114,997,103 - 115,002,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07114,969,699 - 115,002,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,892,674 - 114,924,154 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47111,462,191 - 111,468,045 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17111,467,866 - 111,502,275 (+)NCBI
Celera7102,062,262 - 102,068,065 (+)NCBICelera
Cytogenetic Map7q34NCBI
Ptp4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955454429,792 - 441,268 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955454429,051 - 440,328 (+)NCBIChiLan1.0ChiLan1.0
PTP4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18141,166,898 - 141,187,383 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8141,166,898 - 141,188,314 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08138,062,418 - 138,108,281 (+)NCBIMhudiblu_PPA_v0panPan3
PTP4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,875,467 - 35,886,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,880,005 - 35,886,324 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,734,643 - 35,745,436 (+)NCBI
ROS_Cfam_1.01336,261,162 - 36,271,948 (+)NCBI
UMICH_Zoey_3.11335,981,264 - 35,992,052 (+)NCBI
UNSW_CanFamBas_1.01336,071,127 - 36,081,934 (+)NCBI
UU_Cfam_GSD_1.01336,491,590 - 36,502,389 (+)NCBI
Ptp4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053032,616,806 - 2,626,450 (-)NCBI
SpeTri2.0NW_00493647010,042,903 - 10,052,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTP4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,345,118 - 2,364,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,345,119 - 2,376,765 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTP4A3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18135,663,128 - 135,672,523 (+)NCBI
ChlSab1.1 Ensembl8135,663,149 - 135,671,300 (+)Ensembl
Vero_WHO_p1.0NW_0236660394,456,641 - 4,500,393 (-)NCBI
Ptp4a3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473514,964,403 - 14,977,441 (-)NCBI

Position Markers
RH41881  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378142,441,347 - 142,441,486UniSTSGRCh37
Build 368142,510,529 - 142,510,668RGDNCBI36
Celera8138,607,771 - 138,607,910RGD
Cytogenetic Map8q24.3UniSTS
HuRef8137,758,723 - 137,758,862UniSTS
GeneMap99-GB4 RH Map8566.1UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR551Ahsa-miR-551aOncomiRDBexternal_infoNANA22469786
MIR495hsa-miR-495-3pOncomiRDBexternal_infoNANA22469786

Predicted Target Of
Summary Value
Count of predictions:2478
Count of miRNA genes:579
Interacting mature miRNAs:654
Transcripts:ENST00000329397, ENST00000349124, ENST00000520105, ENST00000521578, ENST00000523147, ENST00000524028
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 1 1 1 3 11 1
Medium 2219 2687 1294 279 1467 137 4204 2157 2829 334 1350 1529 150 1 1199 2740 2 1
Low 215 303 423 341 440 323 147 32 884 77 93 73 25 5 47 2 1
Below cutoff 5 1 3 1 28 2 5 5 15 7 6 11 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006716500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC100803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC241442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI742376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE778111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ637038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U87168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000329397   ⟹   ENSP00000332274
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,421,388 - 141,432,454 (+)Ensembl
RefSeq Acc Id: ENST00000349124   ⟹   ENSP00000331730
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,421,388 - 141,432,454 (+)Ensembl
RefSeq Acc Id: ENST00000520105   ⟹   ENSP00000428758
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,391,995 - 141,431,520 (+)Ensembl
RefSeq Acc Id: ENST00000521578   ⟹   ENSP00000428976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,392,021 - 141,432,454 (+)Ensembl
RefSeq Acc Id: ENST00000523147   ⟹   ENSP00000428725
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,392,021 - 141,426,951 (+)Ensembl
RefSeq Acc Id: ENST00000524028   ⟹   ENSP00000430332
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,422,018 - 141,431,520 (+)Ensembl
RefSeq Acc Id: ENST00000680615   ⟹   ENSP00000505068
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,416,142 - 141,432,415 (+)Ensembl
RefSeq Acc Id: ENST00000681443   ⟹   ENSP00000506615
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,417,909 - 141,431,520 (+)Ensembl
RefSeq Acc Id: NM_007079   ⟹   NP_009010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,421,388 - 141,432,454 (+)NCBI
GRCh378142,402,093 - 142,442,554 (+)NCBI
Build 368142,501,189 - 142,510,802 (+)NCBI Archive
HuRef8137,748,484 - 137,759,930 (+)NCBI
CHM1_18142,471,719 - 142,482,782 (+)NCBI
Sequence:
RefSeq Acc Id: NM_032611   ⟹   NP_116000
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,392,021 - 141,432,454 (+)NCBI
GRCh378142,402,093 - 142,442,554 (+)NCBI
Build 368142,501,189 - 142,510,802 (+)NCBI Archive
HuRef8137,748,484 - 137,759,930 (+)NCBI
CHM1_18142,471,719 - 142,482,782 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005250764   ⟹   XP_005250821
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,416,115 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006716500   ⟹   XP_006716563
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,391,995 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516803   ⟹   XP_011515105
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,413,291 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516805   ⟹   XP_011515107
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,391,996 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017012998   ⟹   XP_016868487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,391,995 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017012999   ⟹   XP_016868488
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,391,995 - 141,432,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024447057   ⟹   XP_024302825
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,417,960 - 141,432,454 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_116000   ⟸   NM_032611
- Peptide Label: isoform 1
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_009010   ⟸   NM_007079
- Peptide Label: isoform 2
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005250821   ⟸   XM_005250764
- Peptide Label: isoform X1
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006716563   ⟸   XM_006716500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011515107   ⟸   XM_011516805
- Peptide Label: isoform X1
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011515105   ⟸   XM_011516803
- Peptide Label: isoform X1
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016868487   ⟸   XM_017012998
- Peptide Label: isoform X3
- UniProtKB: O75365 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016868488   ⟸   XM_017012999
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024302825   ⟸   XM_024447057
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000331730   ⟸   ENST00000349124
RefSeq Acc Id: ENSP00000428758   ⟸   ENST00000520105
RefSeq Acc Id: ENSP00000428976   ⟸   ENST00000521578
RefSeq Acc Id: ENSP00000428725   ⟸   ENST00000523147
RefSeq Acc Id: ENSP00000430332   ⟸   ENST00000524028
RefSeq Acc Id: ENSP00000332274   ⟸   ENST00000329397
RefSeq Acc Id: ENSP00000506615   ⟸   ENST00000681443
RefSeq Acc Id: ENSP00000505068   ⟸   ENST00000680615
Promoters
RGD ID:7214271
Promoter ID:EPDNEW_H12882
Type:initiation region
Name:PTP4A3_1
Description:protein tyrosine phosphatase type IVA, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,421,447 - 141,421,507EPDNEW
RGD ID:6813492
Promoter ID:HG_ACW:79244
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PTP4A3.IAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368142,493,831 - 142,494,331 (+)MPROMDB
RGD ID:6813488
Promoter ID:HG_ACW:79246
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PTP4A3.HAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368142,496,131 - 142,496,631 (+)MPROMDB
RGD ID:6813487
Promoter ID:HG_ACW:79247
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:PTP4A3.DAPR07,   PTP4A3.FAPR07,   PTP4A3.KAPR07,   PTP4A3.MAPR07,   PTP4A3.QAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 368142,497,029 - 142,497,529 (+)MPROMDB
RGD ID:6806820
Promoter ID:HG_KWN:62213
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:ENST00000327627,   NM_007079,   NM_032611,   UC010MET.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368142,500,179 - 142,500,679 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141131265-142117372)x3 copy number gain See cases [RCV000052186] Chr8:141131265..142117372 [GRCh38]
Chr8:142141364..143198733 [GRCh37]
Chr8:142210546..143196640 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
NM_007079.3(PTP4A3):c.99C>T (p.Phe33=) single nucleotide variant Malignant melanoma [RCV000068186] Chr8:141422339 [GRCh38]
Chr8:142432439 [GRCh37]
Chr8:142501621 [NCBI36]
Chr8:8q24.3
not provided
NC_000008.11:g.141405741A>G single nucleotide variant Lung cancer [RCV000107204] Chr8:141405741 [GRCh38]
Chr8:142415841 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142438569-142482615) copy number gain Abnormality of esophagus morphology [RCV000416898] Chr8:142438569..142482615 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141850516-143511413)x3 copy number gain See cases [RCV000512275] Chr8:141850516..143511413 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:126892814-143750028)x1 copy number loss not provided [RCV001006144] Chr8:126892814..143750028 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
NM_032611.3(PTP4A3):c.199-5C>T single nucleotide variant not provided [RCV000948810] Chr8:141426934 [GRCh38]
Chr8:142437034 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9636 AgrOrtholog
COSMIC PTP4A3 COSMIC
Ensembl Genes ENSG00000184489 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000275575 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000331730 UniProtKB/Swiss-Prot
  ENSP00000332274 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428725 UniProtKB/TrEMBL
  ENSP00000428758 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428976 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000430332 UniProtKB/TrEMBL
  ENSP00000481205 UniProtKB/Swiss-Prot
  ENSP00000484500 UniProtKB/Swiss-Prot
  ENSP00000487595 UniProtKB/Swiss-Prot
  ENSP00000487610 UniProtKB/Swiss-Prot
  ENSP00000487861 UniProtKB/TrEMBL
  ENSP00000505068 ENTREZGENE
  ENSP00000506615 ENTREZGENE
Ensembl Transcript ENST00000329397 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000349124 UniProtKB/Swiss-Prot
  ENST00000520105 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000521578 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000523147 UniProtKB/TrEMBL
  ENST00000524028 UniProtKB/TrEMBL
  ENST00000614325 UniProtKB/Swiss-Prot
  ENST00000622569 UniProtKB/Swiss-Prot
  ENST00000633262 UniProtKB/TrEMBL
  ENST00000633518 UniProtKB/Swiss-Prot
  ENST00000633621 UniProtKB/Swiss-Prot
  ENST00000680615 ENTREZGENE
  ENST00000681443 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000184489 GTEx
  ENSG00000275575 GTEx
HGNC ID HGNC:9636 ENTREZGENE
Human Proteome Map PTP4A3 Human Proteome Map
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
KEGG Report hsa:11156 UniProtKB/Swiss-Prot
NCBI Gene 11156 ENTREZGENE
OMIM 606449 OMIM
PharmGKB PA33979 PharmGKB
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E5RFQ4_HUMAN UniProtKB/TrEMBL
  E5RGR3_HUMAN UniProtKB/TrEMBL
  O75365 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8IVN5 UniProtKB/Swiss-Prot
  Q99849 UniProtKB/Swiss-Prot
  Q9BTW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTP4A3  protein tyrosine phosphatase 4A3    protein tyrosine phosphatase type IVA, member 3  Symbol and/or name change 5135510 APPROVED
2011-08-16 PTP4A3  protein tyrosine phosphatase type IVA, member 3  PTP4A3  protein tyrosine phosphatase type IVA, member 3  Symbol and/or name change 5135510 APPROVED