UBR5 (ubiquitin protein ligase E3 component n-recognin 5) - Rat Genome Database

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Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5) Chlorocebus sabaeus
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Symbol: UBR5
Name: ubiquitin protein ligase E3 component n-recognin 5
RGD ID: 18581181
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of interleukin-17 production (ortholog); negative regulation of smoothened signaling pathway (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH breast cancer (ortholog); Cohen syndrome (ortholog); colon adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase UBR5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,104,325 - 97,257,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,103,220 - 97,257,440 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603943,394,343 - 43,547,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UBR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,104,325 - 97,257,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,103,220 - 97,257,440 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603943,394,343 - 43,547,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
UBR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,252,273 - 102,412,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,252,273 - 102,412,759 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,264,501 - 103,424,928 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,334,745 - 103,493,671 (-)NCBINCBI36Build 36hg18NCBI36
Celera899,450,466 - 99,609,463 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,463,202 - 98,623,328 (-)NCBIHuRef
CHM1_18103,304,790 - 103,465,221 (-)NCBICHM1_1
T2T-CHM13v2.08103,378,173 - 103,538,611 (-)NCBIT2T-CHM13v2.0
Ubr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,966,421 - 38,084,103 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,967,572 - 38,079,098 (-)EnsemblGRCm39 Ensembl
GRCm381537,967,328 - 38,078,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,967,328 - 38,078,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371537,897,083 - 38,008,608 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361537,911,917 - 38,023,442 (-)NCBIMGSCv36mm8
Celera1538,586,135 - 38,667,882 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.1NCBI
Ubr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,000,197 - 71,109,841 (-)NCBIGRCr8
mRatBN7.2769,115,216 - 69,224,843 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,116,761 - 69,224,903 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0776,789,110 - 76,835,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0776,839,661 - 76,907,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,789,531 - 76,853,840 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,906,390 - 76,952,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,467,676 - 73,545,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,488,424 - 73,512,532 (-)NCBI
Celera766,180,320 - 66,255,438 (-)NCBICelera
Cytogenetic Map7q22NCBI
Ubr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,998,513 - 27,083,005 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541726,997,572 - 27,085,511 (-)NCBIChiLan1.0ChiLan1.0
UBR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27119,614,528 - 119,774,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,150,769 - 95,309,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0898,904,557 - 99,064,121 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,066,463 - 101,225,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,067,435 - 101,224,913 (-)Ensemblpanpan1.1panPan2
UBR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,887,408 - 4,023,364 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,879,220 - 4,023,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha133,889,598 - 4,025,534 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,047,718 - 4,183,993 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,047,714 - 4,184,536 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,890,615 - 4,026,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,003,424 - 4,139,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,020,631 - 4,156,590 (-)NCBIUU_Cfam_GSD_1.0
Ubr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,826,821 - 33,919,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,252,951 - 41,344,134 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647041,222,782 - 41,345,755 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,645,809 - 34,793,940 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,645,794 - 34,794,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,744,470 - 37,783,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ubr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,414,549 - 19,530,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,414,582 - 19,530,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000010047   ⟹   ENSCSAP00000008147
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl897,103,220 - 97,257,440 (-)Ensembl
RefSeq Acc Id: XM_008001256   ⟹   XP_007999447
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1897,104,325 - 97,256,927 (-)NCBI
Vero_WHO_p1.0NW_02366603943,394,760 - 43,547,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001257   ⟹   XP_007999448
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1897,104,325 - 97,256,927 (-)NCBI
Vero_WHO_p1.0NW_02366603943,394,760 - 43,547,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001258   ⟹   XP_007999449
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1897,104,329 - 97,257,317 (-)NCBI
Vero_WHO_p1.0NW_02366603943,394,343 - 43,547,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001259   ⟹   XP_007999450
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1897,104,329 - 97,257,317 (-)NCBI
Vero_WHO_p1.0NW_02366603943,394,343 - 43,547,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008001260   ⟹   XP_007999451
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1897,104,325 - 97,256,927 (-)NCBI
Vero_WHO_p1.0NW_02366603943,394,760 - 43,547,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038000223   ⟹   XP_037856151
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603943,394,760 - 43,547,147 (+)NCBI
RefSeq Acc Id: XP_007999451   ⟸   XM_008001260
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007999448   ⟸   XM_008001257
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007999447   ⟸   XM_008001256
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007999450   ⟸   XM_008001259
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007999449   ⟸   XM_008001258
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCSAP00000008147   ⟸   ENSCSAT00000010047
RefSeq Acc Id: XP_037856151   ⟸   XM_038000223
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011959 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010047.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  c-terminal domain of poly(a) binding protein UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro E3_UbLigase_EDD_UBA UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  PABP-dom UniProtKB/TrEMBL
  PABP_HYD UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  UBR-box_UBR5 UniProtKB/TrEMBL
  Znf_UBR UniProtKB/TrEMBL
NCBI Gene UBR5 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE UBR5 UniProtKB/TrEMBL
Pfam E3_UbLigase_EDD UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  PABP UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PABC UniProtKB/TrEMBL
  ZF_UBR UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  PolyA UniProtKB/TrEMBL
  ZnF_UBR1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
  SSF63570 UniProtKB/TrEMBL
UniProt A0A0D9RHQ8_CHLSB UniProtKB/TrEMBL