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Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5) Mus musculus
Symbol: Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Description: Predicted to have ubiquitin-ubiquitin ligase activity. Involved in negative regulation of interleukin-17 secretion and regulation of protein stability. Predicted to localize to several cellular components, including the cytosol; nucleoplasm; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4432411E13Rik; AW549941; C77315; D030042K14; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; Edd; Edd1; extraembryonic development; HECT-type E3 ubiquitin transferase UBR5; hyperplastic discs protein homolog; mKIAA0896
Related Pseudogenes: Gm19037  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1537,967,328 - 38,078,854 (-)Ensembl
GRCm381537,967,328 - 38,078,862 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371537,897,083 - 38,008,608 (-)NCBIGRCm37mm9NCBIm37
MGSCv361537,911,917 - 38,023,442 (-)NCBImm8
Celera1538,586,135 - 38,667,882 (-)NCBICelera
Cytogenetic Map15 B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ubr5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552737
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.