MTX2 (metaxin 2) - Rat Genome Database

Name: MTX2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MTX2 (metaxin 2) Chlorocebus sabaeus

Analyze

Symbol:

MTX2

Name:

metaxin 2

RGD ID:

18580349

Description:

INVOLVED IN mitochondrial transport (inferred); mitochondrion organization (inferred); protein transport (inferred); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; ASSOCIATED WITH Mandibuloacral Dysplasia Progeroid Syndrome (ortholog); megacolon (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN SAM complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

metaxin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTX2 (metaxin 2)	NCBI	Ortholog
Mus musculus (house mouse):	Mtx2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mtx2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mtx2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTX2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTX2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mtx2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MTX2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mtx2 (metaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	61,845,509 - 61,914,661 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	61,845,564 - 61,917,012 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	137,695,873 - 137,765,883 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Mandibuloacral Dysplasia Progeroid Syndrome (ISO)

megacolon (ISO)

split hand-foot malformation 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial transport (IEA)

mitochondrion organization (IEA)

protein transport (IEA)

Cellular Component

cytoplasm (IEA)

membrane (IEA)

mitochondrial outer membrane (IEA)

mitochondrion (IEA)

nucleolus (IEA)

SAM complex (IEA,ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-barrel pathway of mitochondrial protein import (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MTX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	61,845,509 - 61,914,661 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	61,845,564 - 61,917,012 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	137,695,873 - 137,765,883 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MTX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	176,269,442 - 176,338,025 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	176,269,395 - 176,338,025 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	177,134,170 - 177,202,753 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	176,842,383 - 176,910,999 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	176,959,643 - 177,028,258	NCBI
Celera	2	170,743,298 - 170,811,933 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	169,011,032 - 169,079,657 (+)	NCBI		HuRef
CHM1_1	2	177,139,996 - 177,208,619 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	176,757,567 - 176,826,151 (+)	NCBI		T2T-CHM13v2.0

Mtx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	74,656,156 - 74,707,092 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	74,656,147 - 74,708,775 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	74,825,812 - 74,876,748 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	74,825,803 - 74,878,431 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	74,663,869 - 74,714,805 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	74,626,690 - 74,679,270 (+)	NCBI		MGSCv36	mm8
Celera	2	76,496,168 - 76,547,115 (+)	NCBI		Celera
Cytogenetic Map	2	C3	NCBI
cM Map	2	44.13	NCBI

Mtx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	80,137,556 - 80,199,547 (+)	NCBI		GRCr8
mRatBN7.2	3	59,730,206 - 59,792,202 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	59,730,197 - 59,792,201 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	63,117,225 - 63,179,188 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	71,700,873 - 71,762,834 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	69,465,936 - 69,527,955 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	61,756,109 - 61,818,999 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	61,756,148 - 61,818,998 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	68,216,558 - 68,279,582 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	57,460,900 - 57,523,379 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	57,357,271 - 57,419,750 (+)	NCBI
Celera	3	59,247,074 - 59,309,016 (+)	NCBI		Celera
Cytogenetic Map	3	q23	NCBI

Mtx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	20,359,527 - 20,412,742 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	20,359,524 - 20,412,473 (-)	NCBI	ChiLan1.0	ChiLan1.0

MTX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	78,938,063 - 79,001,361 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	78,953,051 - 79,016,335 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	63,550,345 - 63,613,626 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	181,258,622 - 181,321,912 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	181,258,622 - 181,321,912 (+)	Ensembl	panpan1.1		panPan2

MTX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	20,067,577 - 20,134,303 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	20,067,424 - 20,390,053 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	20,088,010 - 20,143,656 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	20,220,108 - 20,276,530 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	20,209,088 - 20,276,367 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	20,293,892 - 20,349,526 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	20,294,474 - 20,350,096 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	20,406,105 - 20,461,748 (+)	NCBI		UU_Cfam_GSD_1.0

Mtx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	137,189,131 - 137,245,686 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	5,742,987 - 5,799,652 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	5,743,004 - 5,799,326 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	82,061,385 - 82,139,072 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	82,061,381 - 82,139,073 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	91,528,880 - 91,635,859 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Mtx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	13,398,713 - 13,459,695 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	13,399,293 - 13,459,819 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36		39
Low		20	21
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007965437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007965438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000012507 ⟹ ENSCSAP00000010540

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	10	61,845,564 - 61,917,012 (+)	Ensembl

RefSeq Acc Id:

XM_007965437 ⟹ XP_007963628

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	10	61,845,509 - 61,914,661 (+)	NCBI
Vero_WHO_p1.0	NW_023666040	137,695,873 - 137,765,883 (-)	NCBI

Sequence:

show sequence

GCCGGCGGAATCGCTCGAGTGTCGTTTCGGCTGCGCCGGAAGTTCCTAGCAGGGCCTGGCGGTA
ACCTTCGGGGCGTCGCTGTAGCTGCCGCTGCTGCTGCAGTGGGCTTTGCGGGTCTGAACCTCGG
CGGGGCTAGGGTAGTTAACTGCCGAGAGTCGCCAGGTTTGCGGTGGAGGACGCTGAGGCCCGTG
GGGGGCAGGCACACCGGCGCAGGGCCTCCCAGCCGACATGTCTCTAGTGGCGGAAGCCTTCGTC
TCCCAGATTGCAGCTGCGGAACCTTGGCCTGAAAATGCTACATTATATCAGCAATTGAAAGGGG
AGCAAATTTTACTTTCTGACAATGCAGCTTCTCTTGCAGTGCAGGCCTTTTTGCAAATGTGTAA
CTTGCCTATCAAAGTAGTTTGTAGGGCAAATGCAGAATATATGTCTCCATCTGGTAAAGTACCT
TTTATTCATGTGGGAAATCAAGTAGTATCAGAACTTGGTCCAATAGTCCAATTTGTTAAAGCCA
AGGGCCATTCTCTTAGTGATGGGCTGGGTGAAGTCCAAAAAGCAGAAATGAAAGCTTACATGGA
ATTAGTCAACAATATGCTGTTGACTGCAGAGCTGTATCTTCAGTGGTGTGATGAAGCTACAGTA
GGGGAGATCACTCATGCTAGGTATGGATCTCCTTACCCTTGGCCTCTGAATCATATTTTGGCCT
ATCAGAAACAGTGGGAAGTCAAGCGTAAGATGAAAGCTATTGGATGGGGAAAGAAGACTCTGGA
CCAGGTCTTAGAGGATGTAGACCAATGCTGTCAAGCTCTCTCTCAAAGACTGGGAACACAACCA
TATTTCTTCAATAAGCAGCCTACTGAACTTGATGCACTGGTATTTGGCCATCTGTACACCATTC
TTACCACACAGTTGACGAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGC
TTTCTGTAGGAGAATTGAACAGCACTATTTTGAAGATCGTGGTAAAGGCAGGCTCTCATAGAGT
TATGTGTTAGTCTCAGAAGTCTTAACTTTTGAAAGATGTTTTACTTGAATGTTAGATATTGATG
TCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAAACAAATTATATAATGTATCTTA
TATATGTGCTTTATATTGTTATTTGTGTATACATTAAAATCTGAATTATTTCATCTGATATGTC
ATTCTGTATCTTGAAATTTTTGTTTCCTTGAAACATGCATGCATATAAAAATAAAGCTTAAACA
ACTGTATGGATATTACATTTACCTTCTTTTGATTTTTCTGAAAGTCATTCACTGAATTTTACAC
ATGTGGAATAAACAGTGTCTTTTCTAAGGCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007963628	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010540
	ENSCSAP00000010540.1

RefSeq Acc Id:	XP_007963628 ⟸ XM_007965437
- UniProtKB:	A0A0D9RPK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000010540 ⟸ ENSCSAT00000012507

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014412	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012507.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Metaxin_GST	UniProtKB/TrEMBL
	Sam37/metaxin_N	UniProtKB/TrEMBL
KEGG Report	csab:103217384	UniProtKB/TrEMBL
NCBI Gene	MTX2	ENTREZGENE
PANTHER	METAXIN RELATED	UniProtKB/TrEMBL
	METAXIN-2	UniProtKB/TrEMBL
Pfam	GST_C_6	UniProtKB/TrEMBL
	Tom37	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47616	UniProtKB/TrEMBL
UniProt	A0A0D9RPK1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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