HEYL (hes related family bHLH transcription factor with YRPW motif like) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: HEYL (hes related family bHLH transcription factor with YRPW motif like) Chlorocebus sabaeus
Analyze
Symbol: HEYL
Name: hes related family bHLH transcription factor with YRPW motif like
RGD ID: 18568899
Description: ENCODES a protein that exhibits AF-1 domain binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN epithelial to mesenchymal transition involved in endocardial cushion formation (ortholog); negative regulation of DNA-binding transcription factor activity (ortholog); negative regulation of gene expression (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Carotid Artery Injuries (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy/enhancer-of-split related with YRPW motif-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12093,230,189 - 93,246,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603323,571,967 - 23,587,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HEYL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12093,230,189 - 93,246,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603323,571,967 - 23,587,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HEYL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38139,623,435 - 39,639,643 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl139,623,435 - 39,639,643 (-)EnsemblGRCh38hg38GRCh38
GRCh37140,089,107 - 40,105,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36139,861,690 - 39,877,935 (-)NCBINCBI36Build 36hg18NCBI36
Build 34139,758,917 - 39,774,411NCBI
Celera138,370,855 - 38,387,100 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,207,488 - 38,223,733 (-)NCBIHuRef
CHM1_1140,204,476 - 40,220,725 (-)NCBICHM1_1
T2T-CHM13v2.0139,487,908 - 39,508,063 (-)NCBIT2T-CHM13v2.0
Heyl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394123,127,349 - 123,143,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4123,127,349 - 123,143,668 (+)EnsemblGRCm39 Ensembl
GRCm384123,233,556 - 123,249,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4123,233,556 - 123,249,875 (+)EnsemblGRCm38mm10GRCm38
MGSCv374122,910,799 - 122,927,113 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,736,156 - 122,752,173 (+)NCBIMGSCv36mm8
Celera4121,565,928 - 121,582,239 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.41NCBI
Heyl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,793,271 - 140,810,262 (+)NCBIGRCr8
mRatBN7.25135,508,160 - 135,525,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,508,160 - 135,525,152 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5138,214,573 - 138,231,698 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,984,540 - 140,001,666 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,991,677 - 140,008,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,923,914 - 140,940,905 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,923,914 - 140,940,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,713,817 - 144,730,808 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,544,185 - 142,561,176 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,549,721 - 142,563,036 (+)NCBI
Celera5134,047,073 - 134,064,064 (+)NCBICelera
Cytogenetic Map5q36NCBI
Heyl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,134,770 - 17,152,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545217,137,066 - 17,152,714 (-)NCBIChiLan1.0ChiLan1.0
HEYL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21187,182,481 - 187,198,009 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11186,320,121 - 186,335,647 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0138,913,549 - 38,929,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,240,114 - 40,256,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,240,118 - 40,256,933 (-)Ensemblpanpan1.1panPan2
Heyl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505855,678,981 - 55,688,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,505,149 - 21,510,624 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,503,763 - 21,513,392 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEYL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,442,661 - 95,459,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1695,442,655 - 95,459,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,532,056 - 88,547,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Heyl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,122,079 - 22,135,252 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,118,995 - 22,135,280 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HEYL
281 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_007979301   ⟹   XP_007977492
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12093,230,189 - 93,246,549 (-)NCBI
Vero_WHO_p1.0NW_02366603323,572,495 - 23,587,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037997432   ⟹   XP_037853360
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603323,571,967 - 23,587,548 (-)NCBI
RefSeq Acc Id: XR_005240225
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603323,571,967 - 23,587,587 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007977492 (Get FASTA)   NCBI Sequence Viewer  
  XP_037853360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016880.1
RefSeq Acc Id: XP_007977492   ⟸   XM_007979301
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S7P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037853360   ⟸   XM_037997432
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S7P1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001134 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017399.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.980 UniProtKB/TrEMBL
  Helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HES_HEY UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
NCBI Gene HEYL ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
  Orange domain-like UniProtKB/TrEMBL
UniProt A0A0D9S7P1 ENTREZGENE, UniProtKB/TrEMBL