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Gene: PRXL2C (peroxiredoxin like 2C) Chlorocebus sabaeus

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Symbol:

PRXL2C

Name:

peroxiredoxin like 2C

RGD ID:

18559459

Description:

INVOLVED IN positive regulation of ERK1 and ERK2 cascade (inferred); positive regulation of glycolytic process (inferred); ASSOCIATED WITH intellectual disability (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AAED1; AhpC/TSA antioxidant enzyme domain containing 1; peroxiredoxin-like 2C; thioredoxin-like protein AAED1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRXL2C (peroxiredoxin like 2C)	NCBI	Ortholog
Mus musculus (house mouse):	Prxl2c (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prxl2c (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRXL2C (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRXL2C (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRXL2C (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prxl2c (peroxiredoxin like 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	106,486,772 - 106,500,124 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	106,486,811 - 106,499,618 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	94,883,326 - 94,897,531 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of glycolytic process (IEA)

References

Genomics

Comparative Map Data

PRXL2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	106,486,772 - 106,500,124 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	106,486,811 - 106,499,618 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	94,883,326 - 94,897,531 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PRXL2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	96,639,577 - 96,655,317 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	96,639,577 - 96,655,317 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	99,401,859 - 99,417,599 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	98,443,354 - 98,457,420 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	69,845,106 - 69,859,172 (-)	NCBI		Celera
Cytogenetic Map	9	q22.33	NCBI
HuRef	9	69,014,734 - 69,028,253 (-)	NCBI		HuRef
CHM1_1	9	99,550,355 - 99,564,421 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	108,811,352 - 108,827,123 (-)	NCBI		T2T-CHM13v2.0

Prxl2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	64,437,612 - 64,460,524 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	64,423,094 - 64,460,524 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	64,289,798 - 64,312,710 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	64,275,280 - 64,312,710 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	64,393,144 - 64,414,018 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	64,301,606 - 64,326,737 (-)	NCBI		MGSCv36	mm8
Celera	13	65,956,327 - 65,976,100 (-)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	33.26	NCBI

Prxl2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	817,932 - 849,965 (+)	NCBI		GRCr8
mRatBN7.2	17	812,199 - 839,536 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	812,213 - 844,075 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	830,906 - 848,128 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	2,373,483 - 2,390,705 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	828,334 - 845,556 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	1,798,224 - 1,830,011 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	1,798,388 - 1,830,001 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	1,787,497 - 1,819,908 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	6,336,052 - 6,370,548 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	1,672,532 - 1,704,457 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

PRXL2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	42,796,286 - 42,810,351 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	42,798,683 - 42,812,729 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	67,737,639 - 67,751,691 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	95,857,770 - 95,889,532 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

PRXL2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	70,199,278 - 70,209,026 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	70,199,357 - 70,208,534 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	70,962,502 - 70,972,184 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	70,487,981 - 70,508,109 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	70,498,486 - 70,509,863 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	70,312,093 - 70,321,759 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	70,074,911 - 70,084,654 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	70,786,250 - 70,795,855 (+)	NCBI		UU_Cfam_GSD_1.0

PRXL2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	25,428,164 - 25,446,185 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	25,428,129 - 25,444,609 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	76,570,687 - 76,584,991 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Prxl2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	17,901,544 - 17,918,042 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624753	17,901,281 - 17,922,146 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PRXL2C
291 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007969892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007969893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000004795 ⟹ ENSCSAP00000003037

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	106,486,811 - 106,499,618 (+)	Ensembl

RefSeq Acc Id:

XM_007969892 ⟹ XP_007968083

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	106,486,772 - 106,500,124 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	94,883,326 - 94,897,531 (+)	NCBI

Sequence:

show sequence

GCTGGCAGAGCGGACCCAGGCCCTTGGCCGCCCCGCGTCATGGCCGCGCCCGCCCCGGTCACGC
GGCAGGTTAGCGGCGGCACCGCCCCGGTCCCGGCCCCGAGCGGCCCCGACCGTGGGCAGCCCCT
GGCAGCCGCCGTGGCCGAGCTGCCGGTGCTGGACGCCCGCGGGCAGCGGGTACCTTTCGGCGCG
CTGTTCCGGGAGCGCCGCGCCGTGGTGGTGTTCGTGCGGCATTTTCTGTGTTACATCTGCAAGG
AATACGTAGAGGATCTGGCCAAAATCCCGAAGAGTTTCTTACAAGAAGCAGATGTCACCCTTAT
AGTGATTGGACAGTCATCCTACCATCATATTGAGCCTTTTTGCAGACTGACTGGATATTCTCAT
GAAATCTATGTCGATCCTGAGAGAGAAATTTATAAAAGATTGGGAATGAAACGAGGTGAAGAAA
TTGCCTCCTCAGGACAGAGCCCCCACGTAAAATCAAATCTACTCTCAGGAAGCCTTCAGAGCCT
GTGGCGGGCAGTGACCGGCCCGCTCTTTGATTTTCAAGGAGACCCAGCTCAGCAAGGTGGAATC
CTCATTTTAGGTCCAGGTAACAACATCCATTTTATACACCGCGATAGGAATAGGTTGGATCACA
AACCTATCAACTCTGTTTTACAGCTTGTCGGAGTTCAGCATGTGAACTTTACAAACAGACCTTC
AGTTATCCATGTGTGACTTCAAATGCAATCAGTCACTTTCAGCTGGACCTTCTGGAATGTGACC
TTCAATATCCTCGTGCAGTGTCTAACCTGCTGTCCCTTCCCAGCCTTTGAGGAGTTAGGGAAGC
ATAAAGGGGGCTTGAACCAGTTGAATTGCATGCTGGGAGGCATCAGTTGTCAAAAATGTGATAT
ATACTTCCATTTTATAACTTTTAACATTTTATACAAAATAACAAAAATGAATATACAAAACATA
ACTTTAAACCTATAAAACGTATAAAATCATAAATATTTAAATTATTTTACATTATGGTATATTC
AGTCAATGAAAGATGTTTTTGGCAATGTAAATTCTGATGAATATATAAAGGGACGGGAGAGCAG
CAGAAGACCATTGTATTCAGTGAAGAAGACAAAATATCAAATTCTGTCAACAATGTAACTTCAT
TTTTATATGTATATATTTGTATTTTTGTATGCTTAGGAAAAAGACAATGAACACCAAAATGTTG
CCAGTAGGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007968083	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000003037
	ENSCSAP00000003037.1

RefSeq Acc Id:	XP_007968083 ⟸ XM_007969892
- UniProtKB:	A0A0D9R348 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000003037 ⟸ ENSCSAT00000004795

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000006764	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000004795.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	PXL2A/B/C	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
KEGG Report	csab:103219814	UniProtKB/TrEMBL
NCBI Gene	PRXL2C	ENTREZGENE
PANTHER	PEROXIREDOXIN-LIKE 2C	UniProtKB/TrEMBL
	PTHR28630	UniProtKB/TrEMBL
Pfam	AhpC-TSA_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A0D9R348	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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