COPS6 (COP9 signalosome subunit 6)

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Gene: COPS6 (COP9 signalosome subunit 6) Chlorocebus sabaeus

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Symbol:

COPS6

Name:

COP9 signalosome subunit 6

RGD ID:

18556214

Description:

ENCODES a protein that exhibits metallopeptidase activity (inferred); INVOLVED IN protein deneddylation (inferred); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

COP9 signalosome complex subunit 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,986,194 - 12,989,189 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,986,346 - 12,989,174 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,283,730 - 3,286,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

human immunodeficiency virus infectious disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

prostate cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein deneddylation (IEA)

Cellular Component

COP9 signalosome (IEA)

cytoplasm (IEA,ISO)

nucleoplasm (IEA)

nucleus (IEA,ISO)

Molecular Function

metallopeptidase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

COPS6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,986,194 - 12,989,189 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,986,346 - 12,989,174 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,283,730 - 3,286,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

COPS6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,088,969 - 100,092,187 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,088,969 - 100,092,187 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	99,686,592 - 99,689,810 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,524,519 - 99,527,759 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	99,331,233 - 99,334,471	NCBI
Celera	7	94,421,242 - 94,424,482 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,322,234 - 94,325,474 (+)	NCBI		HuRef
CHM1_1	7	99,616,742 - 99,619,982 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,328,815 - 101,332,033 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,046,703 - 99,049,943 (+)	NCBI

Cops6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,159,364 - 138,162,246 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	138,159,333 - 138,162,908 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	138,161,102 - 138,163,984 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,161,071 - 138,164,646 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	138,602,330 - 138,605,212 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,390,890 - 138,393,772 (+)	NCBI		MGSCv36	mm8
Celera	5	135,140,434 - 135,143,316 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.97	NCBI

Cops6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,152,688 - 22,155,527 (+)	NCBI		GRCr8
mRatBN7.2	12	17,038,979 - 17,041,818 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	17,038,979 - 17,046,371 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,862,350 - 17,865,183 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,486,094 - 18,488,927 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,539,500 - 17,542,333 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,303,387 - 19,306,226 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,303,387 - 19,306,226 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	21,361,017 - 21,363,856 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	17,604,017 - 17,606,856 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	17,587,845 - 17,596,347 (+)	NCBI
Celera	12	18,969,149 - 18,971,988 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Cops6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	770,271 - 775,489 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955573	770,271 - 775,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

COPS6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	118,008,389 - 118,011,377 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,273,021 - 166,276,006 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	92,124,166 - 92,127,165 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,557,778 - 105,560,998 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,557,778 - 105,560,998 (+)	Ensembl	panpan1.1		panPan2

COPS6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,500,715 - 9,503,481 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,500,724 - 9,503,328 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	6	9,437,718 - 9,440,669 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,437,717 - 9,440,346 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,287,044 - 9,289,721 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	9,267,344 - 9,270,300 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,446,955 - 9,449,633 (-)	NCBI		UU_Cfam_GSD_1.0

Cops6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,798,483 - 133,801,487 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	235,089 - 240,440 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	235,087 - 237,779 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COPS6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	7,982,892 - 8,005,633 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	8,002,702 - 8,005,545 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Cops6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,894,626 - 16,899,934 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	16,894,625 - 16,899,369 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008018593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000015929 ⟹ ENSCSAP00000013856

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	28	12,986,346 - 12,989,174 (-)	Ensembl

RefSeq Acc Id:

XM_008018593 ⟹ XP_008016784

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	28	12,986,194 - 12,989,189 (-)	NCBI
Vero_WHO_p1.0	NW_023666070	3,283,730 - 3,286,718 (+)	NCBI

Sequence:

show sequence

GAAGGAAGGGGGCGGGGCCGAGGCTGGCGGGCGCGGGGAAAATGGCGGCGGCGGCGGCTGCAGC
TACAAACGGGACCGGAGGGAGCAGCGGGATGGAGGTGGATGCAGCAGTAGTTCCCAGCGTGATG
GCCTCTGGAGTGACTGGGAGTGTTTCCGTCGCTCTCCATCCCCTTGTCATTCTCAACATCTCTG
ACCACTGGATCCGCATGCGCTCCCAGGAGGGGCGGCCTGTGCAGGTGATTGGGGCTTTGATTGG
CAAGCAGGAGGGCCGAAATATCGAGGTGATGAACTCCTTTGAGCTGCTGTCCCACACCGTGGAA
GAGAAGATTATAATTGACAAGGAATATTATTACACCAAGGAGGAGCAGTTTAAACAGGTGTTCA
AGGAGCTGGAGTTTCTGGGTTGGTATACCACAGGGGGGCCACCTGACCCCTCGGACATCCACGT
CCATAAGCAGGTGTGTGAGATCATTGAGAGCCCCCTCTTTCTGAAGTTGAACCCTATGACCAAG
CACACAGATCTTCCTGTCAGCGTTTTTGAGTCTGTCATCGATATAATCAATGGAGAGGCCACAA
TGCTGTTTGCTGAGCTGACCTACACTCTGGCCACAGAGGAAGCGGAACGCATTGGTGTAGACCA
CGTAGCCCGAATGACAGCAACAGGCAGTGGAGAGAACTCCACTGTGGCTGAACACCTGATAGCA
CAGCACAGCGCCATCAAGATGCTGCACAGCCGCGTCAAGCTCATCTTGGAGTACGTCAAGGCCT
CTGAAGCGGGAGAGGTCCCCTTTAATCATGAGATCCTGCGGGAGGCCTATGCTCTGTGTCACTG
CCTCCCGGTGCTCAGCACAGACAAGTTCAAGACAGATTTTTATGATCAATGCAACGACGTGGGG
CTCATGGCCTACCTTGGCACCATCACCAAAACGTGCAACACCATGAACCAGTTTGTGAACAAGT
TCAACGTCCTCTATGATCGACAAGGCATCGGCAGGCGAATGCGCGGGCTCTTCTTCTGATGAGG
GTACTTGAAGGGCTGATGGACAGGGGTCAGGCAACTGTCGCAAAGGGGAGGGCGCTACACTTCA
TTGAGAGAAACCGCTGTCATTAATAATAAAGGGGAGCAGCCCCCGAGCACCCCTGCTGGTGGCT
CTGTCCTCTCTGTTAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008016784	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013856
	ENSCSAP00000013856.1

RefSeq Acc Id:	XP_008016784 ⟸ XM_008018593
- UniProtKB:	A0A0D9RZ17 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000013856 ⟸ ENSCSAT00000015929

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017840	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015929.1	UniProtKB/TrEMBL
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/TrEMBL
InterPro	JAMM/MPN+_dom	UniProtKB/TrEMBL
	MPN	UniProtKB/TrEMBL
	MPN_CSN6	UniProtKB/TrEMBL
	Rpn11/EIF3F_C	UniProtKB/TrEMBL
NCBI Gene	COPS6	ENTREZGENE
PANTHER	COP9 SIGNALOSOME COMPLEX SUBUNIT 6	UniProtKB/TrEMBL
	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED	UniProtKB/TrEMBL
Pfam	JAB	UniProtKB/TrEMBL
	MitMem_reg	UniProtKB/TrEMBL
PROSITE	MPN	UniProtKB/TrEMBL
SMART	JAB_MPN	UniProtKB/TrEMBL
UniProt	A0A0D9RZ17	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD