MED4 (mediator complex subunit 4) - Rat Genome Database

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Gene: MED4 (mediator complex subunit 4) Chlorocebus sabaeus
Analyze
Symbol: MED4
Name: mediator complex subunit 4
RGD ID: 18519389
Description: ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (inferred); transcription coactivator activity (inferred); transcription coregulator activity (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of transcription initiation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH cervical cancer (ortholog); chromosome 13q14 deletion syndrome (ortholog); endometriosis (ortholog); FOUND IN core mediator complex (inferred); mediator complex (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mediator of RNA polymerase II transcription subunit 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1325,990,203 - 26,009,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl325,990,159 - 26,009,438 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,900,930 - 17,920,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeycervical cancer severityISOMED4 (Homo sapiens)9068941mRNA:decreased expression:uterine cervix (human)RGDPMID:19911042 and REF_RGD_ID:12880436
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeychromosome 13q14 deletion syndrome  ISOMED4 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 13q14 deletion syndromeClinVar 
MED4Green Monkeyintellectual disability  ISOMED4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
MED4Green Monkeymitochondrial DNA depletion syndrome 5  ISOMED4 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 5 (encephalomyopathic with or without methylmalonic aciduria)ClinVarPMID:15877282 more ...
MED4Green Monkeyretinoblastoma  ISOMED4 (Homo sapiens)8554872ClinVar Annotator: match by term: RetinoblastomaClinVarPMID:12541220 more ...
MED4Green Monkeyretinoblastoma  ISOMED4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12541220 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeyendometriosis  ISOMED4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22138541


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeypositive regulation of DNA-templated transcription involved_inIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeypositive regulation of transcription initiation by RNA polymerase II involved_inIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeyregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN000324840150520179 TreeGrafterGO_REF:0000118
MED4Green Monkeyregulation of transcription by RNA polymerase II involved_inIEAInterPro:IPR019258150520179 InterProGO_REF:0000002
MED4Green Monkeytranscription by RNA polymerase II involved_inIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeycore mediator complex part_ofIEAPANTHER:PTN000324840150520179 TreeGrafterGO_REF:0000118
MED4Green Monkeycore mediator complex part_ofIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeymediator complex part_ofIEAInterPro:IPR019258150520179 InterProGO_REF:0000002
MED4Green Monkeymediator complex part_ofIEAUniProtKB:Q9CQA5 more ...150520179 EnsemblGO_REF:0000107
MED4Green Monkeynucleoplasm located_inIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
MED4Green Monkeynucleus located_inIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green Monkeynuclear thyroid hormone receptor binding enablesIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeyprotein binding enablesISOUniProtKB:P612019068941 PMID:17438371UniProtPMID:17438371
MED4Green Monkeyprotein binding enablesISOPR:Q8VCS69068941 PMID:14638676MGIPMID:14638676
MED4Green Monkeyprotein binding enablesISOUniProtKB:O95402 and UniProtKB:Q9NWA09068941 PMID:15175163IntActPMID:15175163
MED4Green Monkeyprotein binding enablesISOUniProtKB:Q930749068941 PMID:21293490 and PMID:26496610IntActPMID:21293490 and PMID:26496610
MED4Green Monkeyprotein binding enablesISOUniProtKB:O95402 more ...9068941 PMID:24882805IntActPMID:24882805
MED4Green Monkeyprotein binding enablesISOUniProtKB:A2BDD9 more ...9068941 PMID:32296183IntActPMID:32296183
MED4Green Monkeyprotein binding enablesISOUniProtKB:O95379 and UniProtKB:Q96EZ89068941 PMID:16189514IntActPMID:16189514
MED4Green Monkeyprotein binding enablesISOUniProtKB:Q13503 and UniProtKB:Q8N3L39068941 PMID:28514442IntActPMID:28514442
MED4Green Monkeyprotein binding enablesISOUniProtKB:O00560 more ...9068941 PMID:25416956IntActPMID:25416956
MED4Green Monkeyprotein binding enablesISOUniProtKB:O954029068941 PMID:21729782IntActPMID:21729782
MED4Green Monkeyprotein binding enablesISOUniProtKB:Q135039068941 PMID:24981860IntActPMID:24981860
MED4Green Monkeyprotein binding enablesISOUniProtKB:Q9NWA09068941 PMID:14638676IntActPMID:14638676
MED4Green Monkeyprotein binding enablesISOUniProtKB:O14777 more ...9068941 PMID:25281560IntActPMID:25281560
MED4Green Monkeyprotein binding enablesISOUniProtKB:O95402 more ...9068941 PMID:35271311IntActPMID:35271311
MED4Green Monkeyprotein binding enablesISOUniProtKB:O95402 more ...9068941 PMID:33961781IntActPMID:33961781
MED4Green Monkeytranscription coactivator activity enablesIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
MED4Green Monkeytranscription coregulator activity enablesIEAPANTHER:PTN000324840150520179 TreeGrafterGO_REF:0000118
MED4Green Monkeytranscription coregulator activity enablesIEAInterPro:IPR019258150520179 InterProGO_REF:0000002
MED4Green Monkeytranscription coregulator activity enablesIEAUniProtKB:Q9NPJ6 and ensembl:ENSP00000258648150520179 EnsemblGO_REF:0000107
1 to 20 of 20 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MED4Green MonkeyRNA polymerase II transcription pathway   ISOMED4 (Homo sapiens)9068941 RGDPMID:24088064 and REF_RGD_ID:9681732
PMID:22301074   PMID:30032202  



MED4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1325,990,203 - 26,009,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl325,990,159 - 26,009,438 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,900,930 - 17,920,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MED4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,075,724 - 48,095,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,053,323 - 48,095,131 (-)EnsemblGRCh38hg38GRCh38
GRCh371348,649,860 - 48,669,240 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,548,093 - 47,567,241 (-)NCBINCBI36Build 36hg18NCBI36
Build 341347,548,092 - 47,567,241NCBI
Celera1329,704,843 - 29,723,982 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,441,920 - 29,461,323 (-)NCBIHuRef
CHM1_11348,617,590 - 48,636,992 (-)NCBICHM1_1
T2T-CHM13v2.01347,296,104 - 47,315,464 (-)NCBIT2T-CHM13v2.0
Med4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,747,489 - 73,755,985 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,747,465 - 73,756,289 (+)EnsemblGRCm39 Ensembl
GRCm381473,510,049 - 73,518,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,510,025 - 73,518,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv371473,909,856 - 73,918,352 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361472,244,204 - 72,252,700 (+)NCBIMGSCv36mm8
Celera1471,030,090 - 71,038,619 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.05NCBI
Med4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81555,106,079 - 55,116,354 (+)NCBIGRCr8
mRatBN7.21548,696,542 - 48,706,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,696,511 - 48,706,820 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,837,909 - 52,848,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,949,486 - 53,959,758 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,794,276 - 50,804,563 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,406,543 - 55,416,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,406,543 - 55,416,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01559,128,754 - 59,139,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41554,158,386 - 54,168,660 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11554,174,165 - 54,184,439 (+)NCBI
Celera1548,344,958 - 48,355,232 (+)NCBICelera
Cytogenetic Map15q11NCBI
Med4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,794,115 - 1,812,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,794,863 - 1,812,641 (-)NCBIChiLan1.0ChiLan1.0
MED4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,501,810 - 49,549,339 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,153,026 - 48,200,552 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,227,620 - 29,247,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11347,929,918 - 47,948,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1347,929,918 - 47,948,836 (-)Ensemblpanpan1.1panPan2
MED4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,396,276 - 3,411,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,396,267 - 3,410,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,382,963 - 3,439,510 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0223,468,131 - 3,524,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,509,920 - 3,524,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1223,253,448 - 3,309,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0223,316,446 - 3,372,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,321,556 - 3,377,754 (+)NCBIUU_Cfam_GSD_1.0
Med4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945157,913,380 - 157,930,626 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,396,088 - 1,415,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,397,434 - 1,414,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,551,863 - 19,566,926 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,551,858 - 19,566,915 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,010,002 - 20,019,435 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Med4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247486,770,231 - 6,790,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MED4
480 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20


RefSeq Transcripts XM_007960377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000015838   ⟹   ENSCSAP00000013766
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl325,990,159 - 26,009,438 (-)Ensembl
RefSeq Acc Id: XM_007960377   ⟹   XP_007958568
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1325,990,203 - 26,009,472 (-)NCBI
Vero_WHO_p1.0NW_02366605717,900,930 - 17,920,167 (+)NCBI
Sequence:
Protein RefSeqs XP_007958568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013766.1
RefSeq Acc Id: XP_007958568   ⟸   XM_007960377
- UniProtKB: A0A0D9RYS7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000013766   ⟸   ENSCSAT00000015838



Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000017743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015838.1 UniProtKB/TrEMBL
InterPro Mediator_Med4 UniProtKB/TrEMBL
NCBI Gene MED4 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 UniProtKB/TrEMBL
  PTHR13208 UniProtKB/TrEMBL
Pfam Med4 UniProtKB/TrEMBL
UniProt A0A0D9RYS7 ENTREZGENE, UniProtKB/TrEMBL