MED4 (mediator complex subunit 4)

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Gene: MED4 (mediator complex subunit 4) Chlorocebus sabaeus

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Symbol:

MED4

Name:

mediator complex subunit 4

RGD ID:

18519389

Description:

ENCODES a protein that exhibits nuclear thyroid hormone receptor binding (inferred); transcription coactivator activity (inferred); transcription coregulator activity (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of transcription initiation by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH cervical cancer (ortholog); chromosome 13q14 deletion syndrome (ortholog); endometriosis (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mediator of RNA polymerase II transcription subunit 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	25,990,203 - 26,009,472 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	25,990,159 - 26,009,438 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	17,900,930 - 17,920,167 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cervical cancer (ISO)

chromosome 13q14 deletion syndrome (ISO)

endometriosis (ISO)

intellectual disability (ISO)

mitochondrial DNA depletion syndrome 5 (ISO)

retinoblastoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of DNA-templated transcription (IEA)

positive regulation of transcription initiation by RNA polymerase II (IEA)

regulation of transcription by RNA polymerase II (IEA)

transcription by RNA polymerase II (IEA)

Cellular Component

core mediator complex (IEA)

mediator complex (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

Molecular Function

nuclear thyroid hormone receptor binding (IEA)

protein binding (ISO)

transcription coactivator activity (IEA)

transcription coregulator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MED4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	25,990,203 - 26,009,472 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	25,990,159 - 26,009,438 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666057	17,900,930 - 17,920,167 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MED4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	48,075,724 - 48,095,104 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	48,053,323 - 48,095,131 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	48,649,860 - 48,669,240 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	47,548,093 - 47,567,241 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	47,548,092 - 47,567,241	NCBI
Celera	13	29,704,843 - 29,723,982 (-)	NCBI		Celera
Cytogenetic Map	13	q14.2	NCBI
HuRef	13	29,441,920 - 29,461,323 (-)	NCBI		HuRef
CHM1_1	13	48,617,590 - 48,636,992 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	47,296,104 - 47,315,464 (-)	NCBI		T2T-CHM13v2.0

Med4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	73,747,489 - 73,755,985 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	73,747,465 - 73,756,289 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	73,510,049 - 73,518,545 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	73,510,025 - 73,518,849 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	73,909,856 - 73,918,352 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	72,244,204 - 72,252,700 (+)	NCBI		MGSCv36	mm8
Celera	14	71,030,090 - 71,038,619 (+)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	39.05	NCBI

Med4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	55,106,079 - 55,116,354 (+)	NCBI		GRCr8
mRatBN7.2	15	48,696,542 - 48,706,818 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	48,696,511 - 48,706,820 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	52,837,909 - 52,848,181 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	53,949,486 - 53,959,758 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	50,794,276 - 50,804,563 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	55,406,543 - 55,416,816 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	55,406,543 - 55,416,815 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	59,128,754 - 59,139,027 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	54,158,386 - 54,168,660 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	54,174,165 - 54,184,439 (+)	NCBI
Celera	15	48,344,958 - 48,355,232 (+)	NCBI		Celera
Cytogenetic Map	15	q11	NCBI

Med4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	1,794,115 - 1,812,889 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	1,794,863 - 1,812,641 (-)	NCBI	ChiLan1.0	ChiLan1.0

MED4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	49,501,810 - 49,549,339 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	48,153,026 - 48,200,552 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	29,227,620 - 29,247,082 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	47,929,918 - 47,948,836 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	47,929,918 - 47,948,836 (-)	Ensembl	panpan1.1		panPan2

MED4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	3,396,276 - 3,411,037 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	3,396,267 - 3,410,608 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	3,382,963 - 3,439,510 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	3,468,131 - 3,524,954 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	3,509,920 - 3,524,949 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	3,253,448 - 3,309,631 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	3,316,446 - 3,372,886 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	3,321,556 - 3,377,754 (+)	NCBI		UU_Cfam_GSD_1.0

Med4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	157,913,380 - 157,930,626 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936565	1,396,088 - 1,415,248 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936565	1,397,434 - 1,414,674 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MED4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	19,551,863 - 19,566,926 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	19,551,858 - 19,566,915 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	20,010,002 - 20,019,435 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Med4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624748	6,770,231 - 6,790,385 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007960377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000015838 ⟹ ENSCSAP00000013766

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	3	25,990,159 - 26,009,438 (-)	Ensembl

RefSeq Acc Id:

XM_007960377 ⟹ XP_007958568

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	3	25,990,203 - 26,009,472 (-)	NCBI
Vero_WHO_p1.0	NW_023666057	17,900,930 - 17,920,167 (+)	NCBI

Sequence:

show sequence

ATGACTCTTCCGCCTTCCGAGTCCGCCTCCTCGCCACGCCCCTGCGTCAGCGCGCTCAGCGCGT
GCGCCGGCGGCGGGGCTGTGAGGAAAATGGCTGCGTCTTCGAGTGGTGAGAAGGAGAAAGAGAG
GCTGGGAGGCGGCTTGGGAGTGGCAAGTGGTAACAGCACACGAGAGCGGCTGCTGTCTGCGCTT
GAGGATTTGGAGGTCCTGTCTAGGGAACTTATAGAAATGCTGGCAATTTCAAGAAACCAGAAGT
TGTTACAGGCTGGAGAGGAGAACCAGGTCCTGGAGTTGTTAATTCACCGAGATGGGGAATTTCA
AGAACTAATGAAACTGGCACTTAATCAGGGAAAAATTCATCATGAAATGCAAGTTTTAGAAAAA
GAAGTAGAGAAGAGAGACAGTGATATTCAGCAACTACAAAAACAGCTAAAGGAAGCAGAACAGA
TACTGGCAACAGCTGTTTACCAAGCAAAGGAGAAACTCAAGTCAATAGAAAAAGCAAGAAAAGG
TGCTATCTCCTCTGAAGAAATAATTAAGTATGCACATAGGATCAGTGCAAGTAATGCTGTATGT
GCTCCGCTGACCTGGGTTCCAGGGGACCCCCGGAGACCCTACCCAACTGATTTAGAGATGAGAA
GTGGGTTACTGGGTCAGATGAACAATCCTTCCACTAATGGTGTGAATGGCCATTTACCAGGAGA
TGCACTCGCAGCAGGAAGATTGCCAGATGTTCTTGCTCCACAGTATCCATGGCAGTCAAGTGAC
ATGTCGATGAATATGTTACCACCAAATCATAGTAGTGACTTTTTGTTGGAACCTCCTGGGCATA
ATAAAGAAAATGAAGATGATGTAGAGATTATGTCAACGGACTCCTCAAGCAGTAGTAGTGAGTC
TGATTGAAAAACCGTAAAAGACAATATACAGAATTGAATACTGTAGAATTCCATTTCTTTAACA
GTAGCAGGGAAATGTAAACCACGGGTGACAAAGAATAACCAGGTAAATACTGGCTTTGGTAGAA
TTGTGCAGCCAATGAAAGTCAAAGTAAACTTTCTTTTTAAAGCCAAAGATTATAGTTTTAGTTT
TAAGCCACTAGGTAGATATTTAGGGGAATAGTCAACATTTACTGTTGAAAAGAGAAAGGAGTTG
CTATGTGCTGTCTTACCCTGTTCTGTTCCAGTTTTGCTGGATTTGTACATAGCCGTTCTAGAAA
TAGAGTTGAGGGAAGTGATCCACGTACATATCACTAATAGGCTTCTTGGAATTATTTAGAAAAG
CATTTTTAAGCTGGCAGTGGATGACTGAATAGGCATCATATTTCTTTTTGTGTGTCATTTAAAA
GTAACAAAAACTCCCATTTGACAGTAAAGGCTCTTGGCTTCTGTTGGAGGAATGGGAAATTGTC
TCAATTTGTACAGTTTGTAATTATTGTAATTTTTGTAAATAAATTTGTTTGTACATTGTA

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Protein Sequences


Protein RefSeqs	XP_007958568	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013766.1

RefSeq Acc Id:	XP_007958568 ⟸ XM_007960377
- UniProtKB:	A0A0D9RYS7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000013766 ⟸ ENSCSAT00000015838

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017743	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015838.1	UniProtKB/TrEMBL
InterPro	Mediator_Med4	UniProtKB/TrEMBL
NCBI Gene	MED4	ENTREZGENE
PANTHER	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4	UniProtKB/TrEMBL
	PTHR13208	UniProtKB/TrEMBL
Pfam	Med4	UniProtKB/TrEMBL
UniProt	A0A0D9RYS7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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