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Gene: CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit) Chlorocebus sabaeus

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Symbol:

CHRNA6

Name:

cholinergic receptor nicotinic alpha 6 subunit

RGD ID:

18518363

Description:

ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); membrane depolarization (ortholog); presynaptic modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); Idiopathic Basal Ganglia Calcification 1 (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); dopaminergic synapse (ortholog); postsynaptic membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neuronal acetylcholine receptor subunit alpha-6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	40,750,839 - 40,767,010 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	40,751,375 - 40,766,236 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	1,004,827 - 1,022,056 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

cocaine abuse (ISO)

Idiopathic Basal Ganglia Calcification 1 (ISO)

IMMUNODEFICIENCY 15 (ISO)

immunodeficiency 15B (ISO)

nicotine dependence (ISO)

torsion dystonia 6 (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to nicotine (ISO)

excitatory postsynaptic potential (IEA)

membrane depolarization (ISO)

monoatomic ion transmembrane transport (IEA)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of dopamine secretion (ISO)

regulation of postsynaptic membrane potential (IEA)

Cellular Component

acetylcholine-gated channel complex (ISO)

dopaminergic synapse (ISO)

plasma membrane (IEA)

postsynaptic membrane (IEA,ISO)

presynaptic membrane (ISO)

protein-containing complex (ISO)

synapse (IEA)

Molecular Function

acetylcholine-gated monoatomic cation-selective channel activity (IEA)

heterocyclic compound binding (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CHRNA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	40,750,839 - 40,767,010 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	40,751,375 - 40,766,236 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	1,004,827 - 1,022,056 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CHRNA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	42,752,620 - 42,768,786 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	42,752,620 - 42,796,392 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	42,607,763 - 42,623,929 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	42,726,920 - 42,742,776 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	42,726,936 - 42,742,776	NCBI
Celera	8	41,555,760 - 41,571,616 (-)	NCBI		Celera
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	41,129,999 - 41,146,165 (-)	NCBI		HuRef
CHM1_1	8	42,654,698 - 42,670,848 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	43,020,720 - 43,036,889 (-)	NCBI		T2T-CHM13v2.0

Chrna6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	27,893,240 - 27,903,972 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	27,893,240 - 27,903,972 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	27,403,212 - 27,413,944 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	27,403,212 - 27,413,944 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	28,513,684 - 28,524,416 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	28,869,148 - 28,879,880 (-)	NCBI		MGSCv36	mm8
Celera	8	28,895,511 - 28,906,624 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	16.02	NCBI

Chrna6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	71,400,615 - 71,407,315 (+)	NCBI		GRCr8
mRatBN7.2	16	64,697,741 - 64,704,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	64,697,741 - 64,704,441 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	69,989,064 - 69,996,216 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	73,395,406 - 73,402,558 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	68,633,137 - 68,639,837 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	68,860,018 - 68,866,718 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	68,860,018 - 68,866,718 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	68,486,608 - 68,493,308 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	69,012,201 - 69,018,901 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	69,012,406 - 69,019,107 (+)	NCBI
Celera	16	62,621,116 - 62,627,795 (+)	NCBI		Celera
Cytogenetic Map	16	q12.3	NCBI

Chrna6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955536	166,212 - 172,551 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955536	166,212 - 172,551 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	61,210,352 - 61,225,975 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	36,926,422 - 36,942,028 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	42,000,748 - 42,016,913 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	39,444,447 - 39,460,569 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	39,444,447 - 39,460,569 (-)	Ensembl	panpan1.1		panPan2

CHRNA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	22,990,377 - 23,009,257 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	22,990,167 - 23,009,106 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	23,495,595 - 23,514,480 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	24,742,037 - 24,760,849 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	24,742,086 - 24,760,838 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	23,110,331 - 23,129,174 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	23,675,367 - 23,694,204 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	23,726,376 - 23,745,181 (+)	NCBI		UU_Cfam_GSD_1.0

Chrna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	45,430,209 - 46,072,980 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936785	18,147 - 27,409 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936785	17,588 - 28,565 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	11,725,880 - 11,739,747 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	11,725,880 - 11,739,949 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	12,640,324 - 12,654,370 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Chrna6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624780	462,195 - 477,568 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CHRNA6
403 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system
14	17	17	17	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007962346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000013058 ⟹ ENSCSAP00000011071

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	40,751,375 - 40,766,236 (-)	Ensembl

RefSeq Acc Id:

XM_007962346 ⟹ XP_007960537

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	40,750,839 - 40,767,010 (-)	NCBI
Vero_WHO_p1.0	NW_023666052	1,004,827 - 1,022,056 (+)	NCBI

Sequence:

show sequence

ACCTGTAGTCCCAGCTACTCGGGAAGCTGAGACAGGAGAATGACGTGAACCTGGGAGGTGATCC
ACCATGCTTTGCAATAAGAATATTTAAATAAATGTGAAAATATCCAGGTGGTATCCATTCCTCT
CATTCTCTGACATCTAGTCTCTAGTCCTGGATGATCACTGAACTCAGAAAAGGCACTGGAAGCC
CTGGAGTCAGAAAAACAAAAACAAAAACAAACTTCTGTTCTCTCCAAGCTGCACTCATTAAGAG
AGAAATGAGGATTCATATTGCAGAAAGTTTTCTAACAAGGTTAAGCCTTGATTAACTGGAGAAC
TCCATGAGTCAGAACAAACTTGTTGGGACCTAGCGTGAGCTTTACCTGTAGTTGGAGCTCAGTG
AATTCCCCTAAAATTATGGTTGAAATTGCACCACAGAAAGATCTCAGCCACTCACAGGTGCTTG
TCCTCCCAGGGTCCTGTCTGCCCCAGCATTTCCTTTCTGCTTTTCTTCCCCTTTCTTGCATGAA
GAGACATCTAGGCTGATAGGAAATGTGATGACTCATCTGACATCAGATCGAATCCTTTTTACTC
GCCCTTCATGTCTGCCTCAGTCTCTGATCCTGGGAATAACCATGTGAAGTCCTGGGGATGTTTT
GATTTCTCAGAAGACACACACAGATTGCAGTGGGCTTCTGATGATGTCAAGGTTGGATGCATGT
GGCTGACTGATAGTTCTTTGTTTTCCACAATCCTTTGCCTAGAGAAAAGGAATCCAAGTGTGTT
TTGACCATGCCGACCAGCAAGGGGCAGGGATTCTTTCACAGGGGCTTGTATCTCTGGCTGTGTG
TGTTCACACCTTTCTTTAAAGGCGGTGCGGGCTGTGCAACTGAGGAGAGGCTTTTCCACAAACT
GTTTTCTCATTACAACCAGTTCATCAGGCCCGTGGAAAACGTTTCTGACCCCGTCACGGTGCAC
TTTGAAGTGGCCATCACCCAGCTGGCCAACGTGGATGAAGTAAACCAGATCATGGAAACCAATT
TGTGGCTGCGTCACATCTGGAATGATTATAAATTGCGCTGGGATCCAATGGAATATGATGGCAT
TGAGACTCTTCGAGTTCCCGCGGATAAGATTTGGAAGCCCGACATTGTTCTCTATAACAATGCT
GTTGGTGACTTCCAAGTTGAAGGCAAGACAAAAGCTCTTCTTAAATACAATGGCATGATAACCT
GGACTCCACCAGCTATTTTTAAGAGTTCCTGCCCTATGGATATCACCTTTTTCCCTTTTGATCA
TCAAAACTGTTCCCTAAAATTTGGTTCCTGGACGTATGACAAAGCTGAAATTGATCTTCTAATC
ATTGGATCAAAAGTGGATATGAATGATTTTTGGGAAAACAGTGAATGGGAAATTATTGATGCCT
CTGGCTACAAACATGATATCAAATACAACTGTTGTGAAGAGATATACACAGATATAACGTATTC
TTTCTACATTAGAAGATTGCCGATGTTTTACACAATTAATCTGATCATCCCCTGTCTCTTTATT
TCATTTCTAACCGTGTTGGTCTTTTACCTTCCTTCAGACTGTGGTGAAAAAGTGACGCTTTGTA
TTTCAGTCCTGCTTTCTCTGACTGTGTTTTTGCTGGTCATCACAGAGACCATCCCGTCCACATC
TCTGGTGGTCCCACTGGTGGGTGAGTACCTGCTGTTTACCATGATCTTTGTCACACTGTCCATC
GTGGTGACTGTGTTTGTGTTGAACATACACTACCGCACCCCAACCACGCACACCATGCCCAGGT
GGGTGAAGACAGTTTTCCTGAAGCTGCTGCCCCAAGTCCTGCTGATGAGGTGGCCTCTGGACAA
GACAAGGGGCACAGGCTCTGATACAGTGCCCAGAGGCCTTTCCAGGAGGCCTGCCAAAGGCAAG
TTTGCAAGCCTTGGAGAACCCAGACATCTTAAAGAATGCTTCCACTATCACAAATCAAATGAAC
TTGCCACCAGCAAGAGAAGATTAAATCATCAGCCGTTACAGTGGATGGTGGAAAATTGGGAGCA
CTCGCCTGAAGTTGAAGATGTGATTAACAGTGTTCAATTCATAGCGGAAAACATGAAGAGCCAC
AATGAAACCAAGGAGGTAGAAGATGACTGGAAATACGTGGCCATGGTGGTGGACAGAGTATTTC
TTTGGGTATTTATAATTGTCTGTGTGTTTGGAACTGCAGGGCTATTTCTACAGCCACTACTTGG
GAACACAGGAAAATCTTAAAATGTATTTTCCTTTATGTTCAGAAATTTACAGACACCATATTTG
TTCTGCATTCCCTGCCACAAGGAAAGGAACGCAAAGGCTTCCCACGCAAGTCCCTCATCTGCTA
AAGCTGATGGCTAGATGGAAAAAGAGGACTTTCTTGCACCTCAGGAGGTGGAATATCCTCCACT
GTAGCACAGGGGGAGAAGTGAGAAGGGTTATGACATTAGTGCCCAGATTGGGCAGCACCCACGG
CTACAGTATCAGGTCAGTTTTCTCATGTCTGTGTGTTTGGCTTCCCAGGACACAAATGACTTAC
AATACAGCCTAACTATGTAATTTACATCAAGCCACACTAAGAAGTTCTGCTTCACCTCCAGCGG
TTGCTGTTTCTCAGTATTATGACATGTGACAGGTGAACTCCGGGAATTGGACCTTGCGACATTT
GTGAACTGTTTACAATACTTGTGAACTATTGCATCCTTGATTTCTTGTGCACGTCTCTGTGATG
TAGCTCACCCCCTCAGCATTATTTGATATAGATTGTTTTTTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007960537	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011071
	ENSCSAP00000011071.1

RefSeq Acc Id:	XP_007960537 ⟸ XM_007962346
- UniProtKB:	A0A0D9RR32 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000011071 ⟸ ENSCSAT00000013058

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014981	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013058.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/TrEMBL
KEGG Report	csab:103215696	UniProtKB/TrEMBL
NCBI Gene	CHRNA6	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	NICOTINICR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A0D9RR32	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations