BMP10 (bone morphogenetic protein 10)

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Gene: BMP10 (bone morphogenetic protein 10) Chlorocebus sabaeus

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Symbol:

BMP10

Name:

bone morphogenetic protein 10

RGD ID:

18510565

Description:

ENCODES a protein that exhibits cytokine activity (inferred); growth factor activity (inferred); hormone activity (inferred); INVOLVED IN BMP signaling pathway (ortholog); heart development (ortholog); kidney development (ortholog); ASSOCIATED WITH bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); Fibrosis (ortholog); Left Ventricular Hypertrophy (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	38,253,093 - 38,260,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	38,253,890 - 38,259,621 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	73,717,263 - 73,737,312 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bladder exstrophy-epispadias-cloacal exstrophy complex (ISO)

Fibrosis (ISO)

Left Ventricular Hypertrophy (ISO)

systolic heart failure (ISO)

tetralogy of Fallot (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (IEA)

adult heart development (IEA)

atrial cardiac muscle tissue morphogenesis (IEA)

BMP signaling pathway (IEA,ISO)

cardiac muscle cell proliferation (IEA)

heart development (IEA,ISO)

heart trabecula formation (IEA)

kidney development (IEA,ISO)

negative regulation of cardiac muscle hypertrophy (IEA)

negative regulation of cell growth (IEA)

negative regulation of cell migration (IEA)

negative regulation of endothelial cell migration (IEA)

positive regulation of cardiac muscle cell proliferation (IEA)

positive regulation of cardiac muscle hypertrophy (IEA)

positive regulation of cartilage development (IEA)

positive regulation of cell proliferation involved in heart morphogenesis (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of gene expression (IEA,ISO)

positive regulation of sarcomere organization (IEA)

positive regulation of SMAD protein signal transduction (IEA)

regulation of cardiac muscle contraction (IEA)

regulation of cardiac muscle hypertrophy in response to stress (IEA)

sarcomere organization (ISO)

ventricular cardiac muscle cell development (IEA)

ventricular cardiac muscle tissue morphogenesis (IEA)

Cellular Component

cell surface (IEA)

cytoplasm (IEA)

extracellular region (IEA)

extracellular space (IEA)

Z disc (IEA)

Molecular Function

cytokine activity (IEA)

growth factor activity (IEA)

hormone activity (IEA)

protein binding (ISO)

receptor serine/threonine kinase binding (IEA)

telethonin binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BMP10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	38,253,093 - 38,260,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	38,253,890 - 38,259,621 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	73,717,263 - 73,737,312 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BMP10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	68,860,909 - 68,871,397 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	68,860,909 - 68,871,397 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	69,088,041 - 69,098,529 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	68,946,117 - 68,952,153 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	69,004,263 - 69,010,300	NCBI
Celera	2	68,943,104 - 68,949,140 (-)	NCBI		Celera
Cytogenetic Map	2	p13.3	NCBI
HuRef	2	68,828,848 - 68,834,901 (-)	NCBI		HuRef
CHM1_1	2	69,021,969 - 69,028,022 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	68,873,354 - 68,883,842 (-)	NCBI		T2T-CHM13v2.0

Bmp10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	87,405,976 - 87,411,494 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	87,405,976 - 87,414,659 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	87,428,994 - 87,434,512 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	87,428,994 - 87,437,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	87,378,996 - 87,384,506 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	87,394,674 - 87,400,133 (+)	NCBI		MGSCv36	mm8
Celera	6	89,360,813 - 89,366,323 (+)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	37.96	NCBI

Bmp10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	121,423,936 - 121,439,094 (+)	NCBI		GRCr8
mRatBN7.2	4	119,872,066 - 119,877,694 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,872,045 - 119,878,627 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	125,343,873 - 125,349,500 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	121,118,641 - 121,124,268 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	119,742,883 - 119,748,510 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	119,224,906 - 119,230,534 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	119,225,040 - 119,230,728 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,775,437 - 183,794,686 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	121,596,150 - 121,601,778 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	108,840,882 - 108,846,510 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Bmp10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	16,124,464 - 16,134,012 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	16,124,526 - 16,130,723 (+)	NCBI	ChiLan1.0	ChiLan1.0

BMP10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	57,534,175 - 57,554,763 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	57,538,123 - 57,558,711 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	68,901,944 - 68,912,559 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	70,023,781 - 70,034,383 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	70,023,655 - 70,034,420 (-)	Ensembl	panpan1.1		panPan2

BMP10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	67,717,047 - 67,724,778 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	67,717,980 - 67,724,739 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	67,607,020 - 67,614,740 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	68,739,137 - 68,746,855 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	68,739,148 - 68,746,836 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	68,421,138 - 68,428,850 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	68,721,245 - 68,728,968 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	69,017,443 - 69,025,171 (-)	NCBI		UU_Cfam_GSD_1.0

Bmp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	15,385,288 - 15,391,206 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	13,180,086 - 13,186,004 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	13,180,086 - 13,186,004 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMP10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	73,519,934 - 73,529,950 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	73,519,904 - 73,530,448 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	77,125,882 - 77,132,962 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Bmp10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	4,482,674 - 4,493,329 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	4,482,708 - 4,493,295 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
9	9	20	20	20	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007970391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000013031 ⟹ ENSCSAP00000011044

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	38,253,890 - 38,259,621 (+)	Ensembl

RefSeq Acc Id:

XM_007970391 ⟹ XP_007968582

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	38,253,093 - 38,260,027 (+)	NCBI
Vero_WHO_p1.0	NW_023666045	73,717,263 - 73,737,312 (-)	NCBI

Sequence:

show sequence

TACAGGAGCACACCTGATGATAGATGTAAAGCACTCAGTACAATGCCTGTTTGTAGGAAGCATC
TAATACATTTTAGTTGCCGCTATAACTAAGCACTTGCCTCTTTTTCACATGCCATTTTAGCCAG
ATCAAATAGGTAGGAAAAAAGGCTATCAATCATGAAGTTTATACTTTCCTGTTTCTAAAAAGGT
ACACTTCTAAAAACTTATATAATCCATTTATAGCTATTAACTTAAACTTGGAAAGTTTGGATAC
TTGGTCTGTCTTCAGAAGTGTTTATCTGAGGATGTAAGCCCTACCACTCAAATTACTATGTATC
ACCACTGATGTGCATTATGTTGATTCTTATACCTATTATATGCATGTGTGAAACTAAGCCCCAT
AAAAACAGAATTGAGGCATTCCTGCTGAAAGGAAGTGAATTGAAGGGAAGAGAAGCAGAGCCTT
TGCAAAGAGAAAATTGTCCTATCTCTCAACCAGTGTCAGAATGTGGAAATGTTTACAAAATGCT
CATTAAAAGAAATAGGGATTGCAAGATAGAAACAAATTCTGGTGCACAAGTTTACACTAGAGAG
ATAAGAAAGGCTAGGCCCCTATAGGGGATTTTGTTATCCAATTACTGCAACCTGACTTTTAGGG
GGAGAGGAAGAGTGGTAGGGGGAGGGAGAGAGAGAGGAAGAGTTTCCAAACTTGTCTCCAGTGA
CAGGAGACATTTACGCTCCACAAGATAAAACTGCCACTTAGAGCCCAGGAGAGCTAAACCTTCC
TGGCTTGGCCTAGGGGCTCGAGCGGAGTCATGGGCTCTCTGGTCCTCACACTGTGTGCTCTTTT
CTGCCTGGCAGCTCACTTGGTTTCTGGGAGCCCCATCATGAGCCTAGAGCAGTCTCCTCTGGAA
GAAGATATGCCCCTTTTTGATGATGTTTTCTCAGAGCAAGATGGTGTCGACTTTAACACACTGC
TCCAGAGCATGAAGGATGAGTTTCTCAAGACACTAAACCTCTCTGACATCCCCACGCAGGATTC
AGCCAAGGTGGACCCACCAGAGTACATGTTGGAACTCTACAACAAATTTGCAACGGATCGGACC
TCCATGCCCTCTGCCAACATCATTAGGAGTTTCAAGAATGAAGATCTGTTTTCCCAGCCAGTCA
GTTTTAACGGACTCCGAAAATACCCCCTCCTCTTCAATGTGTCCATTCCTCACCATGAAGAGGT
CATCATGGCTGAACTTAGGCTGTACACACTGGTGCAAAGGGATCGTATGATATACGATGGAGTA
GACCGGAAAATTACCTTTTTTGAAGTGCTGGAGAGCAAAGGGGATAATGAGGGAGAAAGAAACA
TGCTGGTCTTGGTGTCAGGGGAGATCTATGGAACCAACAGTGAGTGGGAGACTTTTGATGTCAC
AGATGCCATCAGACATTGGCAAAAGTCAGGCTCATCCACCCACCAGCTGGAGGTTCACATTGAG
AGCAAACACGATGAAGCTGAGGATGCCAGCAGTGGACGACTGGAAATAGACACCAGTGCCCAGA
ATAAGCATAACCCTTTGCTCATAGTGTTTTCTGATGACCAAAGCAGTGACAAGGAGAGGAAGGA
GGAACTAAATGAAATGATTTCCCATGAGCAACTTCCGGAGCTAGACAACTTGGGCCTGGATGGC
TTTTCTGGTGGACCTGGGGAAGAGGCTTTGTTGCAGATGAGATCAAACATCATCTACGACTCCA
CTGCCCGAATCAGAAGGAATGCCAAAGGAAACTACTGTAAGAGGACCCCGCTCTACATGGACTT
CAAGGAGATTGGGTGGGACTCCTGGATCATCGCTCCGCCTGGATACGAAGCCTATGAATGTCGT
GGTGTTTGTAACTATCCCCTGGCAGAACATCTCACACCCACAAAGCATGCAATTATCCAGGCCT
TGGTCCACCTCAAGAATTCCCAGAAAGCTTCCAAAGCCTGCTGTGTGCCCACAAAGCTTGAGCC
CATCTCCATCCTCTATTTAGACAAAGGCGTCGTCACCTACAAGTTTAAATACGAAGGCATGGCC
GTCTCCGAATGTGGCTGTAGATAGAAGAAGAGTCCTGTGGGCTTATTTAATAACTGTAAATGTG
TATATTTGGTGTTCCTATTTAATGAGATTATTTAATAAGGGTGTACAGTAATAGAGGCTTGCTG
CCTTCAGGAAATGGGACAGGTCGGTTTGTTGTAGGAAATGCATATTTTCCTCTCCAGTTAAGTC
CCTTTCAATCTGTTTTCTCTTTGGACTTGCCATTTCCTGGCAATGCCACCTCCACGTTGATTTG
AAAACAACTCCTAGGCAAAATACAGTGTCAAAAGACACATACTTGTGTATGTATATTTGTACAT
ACATGAACTTACAGAAATCTTTTGGTTCTATGCAGGCAGATTATACTCATCTACATGCATGATT
CACTCAAAAGTGTGCATATTAAAGGCCAATGGTATGTTCTCTGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007968582	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011044.1

RefSeq Acc Id:	XP_007968582 ⟸ XM_007970391
- UniProtKB:	A0A0D9RR05 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000011044 ⟸ ENSCSAT00000013031

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014937	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013031.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_propeptide	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	csab:103220117	UniProtKB/TrEMBL
NCBI Gene	BMP10	ENTREZGENE
PANTHER	BONE MORPHOGENETIC PROTEIN 10	UniProtKB/TrEMBL
	PTHR11848	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A0D9RR05	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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