Bmp10 (bone morphogenetic protein 10) - Rat Genome Database
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Gene: Bmp10 (bone morphogenetic protein 10) Mus musculus
Analyze
Symbol: Bmp10
Name: bone morphogenetic protein 10
RGD ID: 1558624
MGI Page MGI
Description: Is expressed in several structures, including blood; heart; liver; and lung. Used to study tetralogy of Fallot. Orthologous to human BMP10 (bone morphogenetic protein 10).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: b2b2711C; b2b2711Clo; BMP-10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,405,976 - 87,411,494 (+)NCBIGRCm39mm39
GRCm39 Ensembl687,405,976 - 87,414,659 (+)Ensembl
GRCm38687,428,994 - 87,434,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,428,994 - 87,437,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37687,378,996 - 87,384,506 (+)NCBIGRCm37mm9NCBIm37
MGSCv36687,394,674 - 87,400,133 (+)NCBImm8
Celera689,360,813 - 89,366,323 (+)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardinal vein morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal retinal blood vessel morphology  (IEA)
abnormal vascular development  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent atrioventricular cushions  (IAGP)
absent conotruncal ridges  (IAGP)
absent vitelline blood vessels  (IAGP)
arteriovenous malformation  (IAGP)
curly tail  (IEA)
decreased circulating creatinine level  (IEA)
decreased embryo size  (IAGP)
decreased exploration in new environment  (IEA)
decreased fetal cardiomyocyte proliferation  (IAGP)
decreased heart rate  (IAGP)
dilated dorsal aorta  (IAGP)
double outlet right ventricle  (IEA)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged pericardium  (IAGP)
heart hypoplasia  (IAGP)
hemorrhage  (IAGP)
hydrops fetalis  (IAGP)
improved glucose tolerance  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased prepulse inhibition  (IEA)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
pericardial edema  (IAGP)
petechiae  (IEA)
polycystic kidney  (IEA)
preweaning lethality, complete penetrance  (IEA)
pulmonary artery hypoplasia  (IEA)
subarterial ventricular septal defect  (IEA)
thin ventricular wall  (IAGP)
thymus hypoplasia  (IEA)
trabecula carnea hypoplasia  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:10072785   PMID:11238910   PMID:11854453   PMID:12477932   PMID:12666204   PMID:15073151   PMID:15342483   PMID:15525990   PMID:15582777   PMID:15743826   PMID:15902305   PMID:16530167  
PMID:16543498   PMID:16554359   PMID:16798733   PMID:17218603   PMID:17332425   PMID:17336907   PMID:17460765   PMID:17585069   PMID:18267097   PMID:18292603   PMID:18617694   PMID:18832392  
PMID:19727199   PMID:19956691   PMID:20596014   PMID:20651287   PMID:21075835   PMID:21177343   PMID:21304516   PMID:21345597   PMID:21511879   PMID:21550985   PMID:21737454   PMID:21873635  
PMID:21890625   PMID:21983003   PMID:22158708   PMID:22412967   PMID:22566602   PMID:22783020   PMID:22865640   PMID:22992950   PMID:22996691   PMID:23063798   PMID:23200275   PMID:23314057  
PMID:23571217   PMID:23595884   PMID:23812757   PMID:24068960   PMID:24143284   PMID:24335256   PMID:24748541   PMID:24835278   PMID:24952961   PMID:25250575   PMID:25670795   PMID:25807483  
PMID:25848000   PMID:26056270   PMID:26631724   PMID:26641715   PMID:27002738   PMID:27052172   PMID:27166947   PMID:27333774   PMID:27348588   PMID:27626380   PMID:27930960   PMID:27997827  
PMID:28464239   PMID:28732025   PMID:28771943   PMID:29337306   PMID:29409032   PMID:29564768   PMID:29743679   PMID:29791855   PMID:29853617   PMID:29891551   PMID:30165893   PMID:30347193  
PMID:30352686   PMID:30596653   PMID:30936179   PMID:31028279   PMID:31112136   PMID:31311865  


Genomics

Comparative Map Data
Bmp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,405,976 - 87,411,494 (+)NCBIGRCm39mm39
GRCm39 Ensembl687,405,976 - 87,414,659 (+)Ensembl
GRCm38687,428,994 - 87,434,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,428,994 - 87,437,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37687,378,996 - 87,384,506 (+)NCBIGRCm37mm9NCBIm37
MGSCv36687,394,674 - 87,400,133 (+)NCBImm8
Celera689,360,813 - 89,366,323 (+)NCBICelera
Cytogenetic Map6D1NCBI
BMP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl268,860,909 - 68,871,397 (-)EnsemblGRCh38hg38GRCh38
GRCh38268,860,909 - 68,871,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37269,088,041 - 69,098,529 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,946,117 - 68,952,153 (-)NCBINCBI36hg18NCBI36
Build 34269,004,263 - 69,010,300NCBI
Celera268,943,104 - 68,949,140 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef268,828,848 - 68,834,901 (-)NCBIHuRef
CHM1_1269,021,969 - 69,028,022 (-)NCBICHM1_1
Bmp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24119,872,066 - 119,877,694 (+)NCBI
Rnor_6.0 Ensembl4119,225,040 - 119,230,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04119,224,906 - 119,230,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04183,775,437 - 183,794,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,596,150 - 121,601,778 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4108,840,882 - 108,846,510 (+)NCBICelera
Cytogenetic Map4q34NCBI
Bmp10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,124,464 - 16,134,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,124,526 - 16,130,723 (+)NCBIChiLan1.0ChiLan1.0
BMP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A70,023,781 - 70,034,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,023,655 - 70,034,420 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A68,901,944 - 68,912,559 (-)NCBIMhudiblu_PPA_v0panPan3
BMP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1067,717,980 - 67,724,739 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11067,717,047 - 67,724,778 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bmp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649113,180,086 - 13,186,004 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,519,934 - 73,529,977 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,519,904 - 73,530,448 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,125,882 - 77,132,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,253,093 - 38,260,027 (+)NCBI
ChlSab1.1 Ensembl1438,253,890 - 38,259,621 (+)Ensembl
Bmp10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247624,482,708 - 4,493,295 (+)NCBI

Position Markers
Bmp10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38687,434,300 - 87,434,480UniSTSGRCm38
MGSCv37687,384,294 - 87,384,474UniSTSGRCm37
Celera689,366,111 - 89,366,291UniSTS
Cytogenetic Map6D2UniSTS
cM Map6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:76
Interacting mature miRNAs:77
Transcripts:ENSMUST00000032125
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032125   ⟹   ENSMUSP00000032125
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,428,994 - 87,437,677 (+)Ensembl
RefSeq Acc Id: NM_009756   ⟹   NP_033886
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39687,405,976 - 87,411,494 (+)NCBI
GRCm38687,428,994 - 87,434,512 (+)NCBI
MGSCv37687,378,996 - 87,384,506 (+)RGD
Celera689,360,813 - 89,366,323 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033886   ⟸   NM_009756
- Peptide Label: preproprotein
- UniProtKB: Q9R229 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032125   ⟸   ENSMUST00000032125

Promoters
RGD ID:6890328
Promoter ID:EPDNEW_M8615
Type:multiple initiation site
Name:Bmp10_1
Description:Mus musculus bone morphogenetic protein 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38687,428,994 - 87,429,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338820 AgrOrtholog
Ensembl Genes ENSMUSG00000030046 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032125 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032125 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12154 UniProtKB/Swiss-Prot
MGD MGI:1338820 ENTREZGENE
NCBI Gene 12154 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp10 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7ZN66_MOUSE UniProtKB/TrEMBL
  BMP10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6H6S5 UniProtKB/Swiss-Prot
  Q9Z1V8 UniProtKB/Swiss-Prot