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Gene: HOMER3 (homer scaffold protein 3) Chlorocebus sabaeus

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Symbol:

HOMER3

Name:

homer scaffold protein 3

RGD ID:

18505149

Description:

ENCODES a protein that exhibits G protein-coupled glutamate receptor binding (inferred); identical protein binding (inferred); protein domain specific binding (inferred); INVOLVED IN regulation of postsynaptic neurotransmitter receptor activity (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Keratoconus 5 (ortholog); Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homer protein homolog 3; homer scaffolding protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,385,176 - 17,396,506 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	17,385,175 - 17,394,319 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	1,926,336 - 1,937,877 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

Keratoconus 5 (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

progressive myoclonus epilepsy 8 (ISO)

Salivary Gland Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled glutamate receptor signaling pathway (IEA)

negative regulation of calcineurin-NFAT signaling cascade (IEA)

negative regulation of interleukin-2 production (IEA)

regulation of postsynaptic neurotransmitter receptor activity (ISO)

Cellular Component

basal part of cell (IEA)

cytoplasm (IEA)

cytosol (IEA)

glutamatergic synapse (IEA,ISO)

postsynaptic density (IEA,ISO)

synapse (IEA)

Molecular Function

G protein-coupled glutamate receptor binding (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HOMER3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,385,176 - 17,396,506 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	17,385,175 - 17,394,319 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	1,926,336 - 1,937,877 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HOMER3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,929,201 - 18,941,217 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,929,201 - 18,941,261 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	19,040,010 - 19,052,026 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,901,012 - 18,912,983 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,901,011 - 18,912,983	NCBI
Celera	19	18,944,833 - 18,956,865 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,604,424 - 18,624,135 (-)	NCBI		HuRef
CHM1_1	19	19,039,677 - 19,051,708 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,064,989 - 19,077,095 (-)	NCBI		T2T-CHM13v2.0

Homer3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,735,529 - 70,747,011 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,735,477 - 70,747,011 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,282,880 - 70,294,361 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,282,827 - 70,294,361 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	72,806,898 - 72,818,260 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,212,039 - 73,223,342 (+)	NCBI		MGSCv36	mm8
Celera	8	72,839,497 - 72,850,859 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Homer3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,166,141 - 19,176,701 (-)	NCBI		GRCr8
mRatBN7.2	16	19,132,177 - 19,142,739 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,132,162 - 19,142,680 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	19,173,049 - 19,180,462 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,305,565 - 20,312,954 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,226,010 - 19,233,424 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,880,447 - 20,890,968 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,881,518 - 20,890,949 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,732,220 - 20,742,730 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,617,526 - 19,624,915 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,617,523 - 19,624,913 (-)	NCBI
Celera	16	19,323,520 - 19,330,908 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Homer3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	2,755,367 - 2,760,198 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	2,754,970 - 2,760,198 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOMER3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,790,511 - 23,802,790 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,796,727 - 22,808,991 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	18,367,191 - 18,379,454 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	19,374,442 - 19,386,161 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	19,374,442 - 19,385,392 (-)	Ensembl	panpan1.1		panPan2

HOMER3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,179,145 - 44,186,814 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,179,153 - 44,186,814 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,094,561 - 44,102,222 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,666,088 - 44,673,749 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,666,149 - 44,675,444 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	43,903,365 - 43,911,026 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,313,573 - 44,321,234 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,589,003 - 44,596,702 (+)	NCBI		UU_Cfam_GSD_1.0

Homer3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,856,647 - 202,864,512 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,406,326 - 2,413,604 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,406,427 - 2,413,651 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOMER3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	58,913,992 - 58,922,474 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	58,913,949 - 58,922,474 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	58,714,495 - 58,721,277 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Homer3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,971,064 - 1,976,152 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,970,739 - 1,977,750 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HOMER3
332 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007995849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007995850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003264 ⟹ ENSCSAP00000001549

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	17,385,175 - 17,394,319 (-)	Ensembl

RefSeq Acc Id:

XM_007995850 ⟹ XP_007994041

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	17,385,176 - 17,396,506 (-)	NCBI
Vero_WHO_p1.0	NW_023666074	1,926,336 - 1,937,877 (+)	NCBI

Sequence:

show sequence

GGGACCGGAGGCGGCGCGGGCGGCGGCGGCGGCGGCGCAGACAAAGGCGCGGGCGGCGCGGAGG
GCGGCGCGGAGGGCGCGGGCCCGGGAGCCAGGGAGCGAGCGGGGCGCCCGGCAGCGCGGAGTCA
GCGCCGCGGGGGCCGCACCCGACCCGCGCCTGGACACTCGCGGGGCGCCGACCCGGCAGGGGGC
CAAAGCAGCGCTCCTGCCACCTCTCTGGCTGCCCCCTAGAGCCTGCCCATCCCGACCTGACCAA
TGTCCACAGCCAGGGAGCAGCCAATCTTCAGCACACGGGCACACGTGTTCCAGATCGACCCGGC
CACCAAGCGAAACTGGATCCCGGCGGGCAAGCATGCACTCACTGTCTCCTATTTCTACGATGCC
ACCCGCAATGTCTACCGCATCATCAGCATCGGGGGCGCCAAGGCCATCATCAACAGCACTGTCA
CTCCCAACATGACCTTCACCAAAACCTCCCAGAAGTTCGGGCAGTGGGCGGACAGTCGCGCCAA
CACCGTCTACGGCCTTGGCTTTGCCTCTGAACAGCATCTGACACAGTTTGCTGAGAAGTTCCAG
GAAGTGAAGGAAGCAGCCAGGCTGGCCAGGGAGAAGTCTCAGGATGGCGGAGAGCTCACCAGTC
CAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCCCTCGTCAGTGCCAACGGCCCTGG
CGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTA
AAGAAGATGCTGTCAGAGGGCTCCGTAGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCGCTGC
AGGACAGCAACAACAAGTTGGCAGGCGCCCTGCGAGAGGCCAACGCCGCCGCAGCCCAGTGGAG
GCAGCAGCTGGAGGCTCAACGTGCAGAGGCCGAGCGGCTACGGCAGCGGGTGGCTGAGCTGGAG
GCCCAGGCAGCTTCAGAGGTGACCCCGGCCAGCGAGAAGGAGGGGCCGGGCCAGGGCCAGTCAC
TGGAGCAGCTGGAAGCTCTGGTGCAAACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGAC
TGGGGGGCCCCGTGAGGCCCCGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGAAGGTGCAGGAC
CTGGAGACCCGCAATGCGGAACTGGAACACCAGCTGCGGGCGACGGAGCGCAGCCTGGAGGAGG
CACGGGCAGAGCGGGAGCGGGCGCGGGCCGAGGTGGGCCGGGCGGCACAGCTGCTGGACGTCAG
GCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAGGCCGCGCCCTGAGCC
GGGGCTGGTTTTCCATGAACGATTCTGGCCTGGGATGTGGGCCAGGCTGCAGGCGGCATAGTTG
GACCCATTTGTCCTGGAAAGGGACTGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCT
GGGGTGGGCCCCAGCCGGCTCTGGCTGTTGGCAGCTTGGGGGCTGTTTTTGAGCTTCTCATTGT
GTAGAATTTCTAGATCCCCAGATTACATTTCTAAGTGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007994041	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001549.1

RefSeq Acc Id:	XP_007994041 ⟸ XM_007995850
- UniProtKB:	A0A0D9QYW0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000001549 ⟸ ENSCSAT00000003264

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005233	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003264.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.1700	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
InterPro	Homer	UniProtKB/TrEMBL
	Homer_EVH1	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	WH1/EVH1_dom	UniProtKB/TrEMBL
KEGG Report	csab:103234200	UniProtKB/TrEMBL
NCBI Gene	HOMER3	ENTREZGENE
PANTHER	PTHR10918	UniProtKB/TrEMBL
Pfam	WH1	UniProtKB/TrEMBL
PROSITE	WH1	UniProtKB/TrEMBL
SMART	WH1	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
UniProt	A0A0D9QYW0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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