VRK2 (VRK serine/threonine kinase 2) - Rat Genome Database

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Gene: VRK2 (VRK serine/threonine kinase 2) Chlorocebus sabaeus
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Symbol: VRK2
Name: VRK serine/threonine kinase 2
RGD ID: 18485766
Description: ENCODES a protein that exhibits ATP binding (inferred); protein domain specific binding (inferred); protein kinase activity (inferred); INVOLVED IN protein autophosphorylation (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); Fanconi anemia complementation group L (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase VRK2; vaccinia related kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11448,803,149 - 48,909,144 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1448,798,499 - 48,906,712 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604562,835,754 - 62,944,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11448,803,149 - 48,909,144 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1448,798,499 - 48,906,712 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604562,835,754 - 62,944,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
VRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38257,907,592 - 58,159,920 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl257,907,629 - 58,159,920 (+)EnsemblGRCh38hg38GRCh38
GRCh37258,134,727 - 58,387,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36258,127,224 - 58,240,510 (+)NCBINCBI36Build 36hg18NCBI36
Build 34258,185,476 - 58,298,654NCBI
Celera258,116,828 - 58,230,225 (+)NCBICelera
Cytogenetic Map2p16.1NCBI
HuRef258,014,875 - 58,128,335 (+)NCBIHuRef
CHM1_1258,203,888 - 58,317,318 (+)NCBICHM1_1
T2T-CHM13v2.0257,912,292 - 58,164,754 (+)NCBIT2T-CHM13v2.0
Vrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391126,421,398 - 26,544,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1126,421,322 - 26,543,999 (-)EnsemblGRCm39 Ensembl
GRCm381126,471,398 - 26,594,012 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1126,471,322 - 26,593,999 (-)EnsemblGRCm38mm10GRCm38
MGSCv371126,371,401 - 26,493,920 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361126,503,981 - 26,625,366 (-)NCBIMGSCv36mm8
MGSCv361126,371,404 - 26,493,611 (-)NCBIMGSCv36mm8
Celera1128,995,024 - 28,995,410 (+)NCBICelera
Celera1137,253,803 - 37,372,542 (-)NCBICelera
Cytogenetic Map11A3.3NCBI
cM Map1115.94NCBI
Vrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814104,514,815 - 104,635,549 (-)NCBIGRCr8
mRatBN7.214100,313,771 - 100,434,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14100,313,601 - 100,434,527 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14104,646,638 - 104,767,362 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014105,890,724 - 106,011,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014102,362,554 - 102,483,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014110,739,835 - 110,883,836 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14110,739,226 - 110,883,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014110,554,902 - 110,576,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.014110,444,503 - 110,501,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414107,287,844 - 107,450,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114107,300,490 - 107,470,542 (-)NCBI
Celera1499,260,139 - 99,368,196 (-)NCBICelera
Cytogenetic Map14q22NCBI
Vrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542425,282,007 - 25,399,348 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542425,307,221 - 25,397,900 (-)NCBIChiLan1.0ChiLan1.0
VRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21268,197,958 - 68,310,907 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A68,201,910 - 68,314,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A58,158,347 - 58,271,245 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A59,166,949 - 59,419,895 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A59,305,233 - 59,419,895 (+)Ensemblpanpan1.1panPan2
VRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11058,432,144 - 58,544,189 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1058,431,978 - 58,544,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1058,280,905 - 58,497,135 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01059,332,186 - 59,547,978 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1059,435,778 - 59,547,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11059,029,154 - 59,244,640 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01059,313,317 - 59,529,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01059,606,236 - 59,821,676 (+)NCBIUU_Cfam_GSD_1.0
Vrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629224,418,835 - 24,615,182 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364913,958,588 - 4,057,738 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364913,956,171 - 4,057,753 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl383,433,313 - 83,536,980 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1383,435,250 - 83,537,022 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2388,020,677 - 88,122,044 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Vrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248333,663,641 - 3,776,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248333,663,606 - 3,778,598 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VRK2
1718 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000012476   ⟹   ENSCSAP00000010510
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1448,798,499 - 48,906,712 (-)Ensembl
RefSeq Acc Id: XM_007970543   ⟹   XP_007968734
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11448,803,149 - 48,909,144 (-)NCBI
Vero_WHO_p1.0NW_02366604562,835,754 - 62,944,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007970544   ⟹   XP_007968735
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11448,803,149 - 48,908,954 (-)NCBI
Vero_WHO_p1.0NW_02366604562,836,082 - 62,944,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007970545   ⟹   XP_007968736
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11448,803,149 - 48,908,690 (-)NCBI
Vero_WHO_p1.0NW_02366604562,836,492 - 62,944,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007970548   ⟹   XP_007968739
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11448,808,188 - 48,909,144 (-)NCBI
Vero_WHO_p1.0NW_02366604562,835,754 - 62,942,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038006974   ⟹   XP_037862902
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604562,835,754 - 62,942,358 (+)NCBI
RefSeq Acc Id: XM_038006975   ⟹   XP_037862903
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604562,836,082 - 62,944,601 (+)NCBI
RefSeq Acc Id: XM_038006976   ⟹   XP_037862904
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604562,838,359 - 62,944,601 (+)NCBI
RefSeq Acc Id: XP_007968734   ⟸   XM_007970543
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RPH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007968735   ⟸   XM_007970544
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RPH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007968736   ⟸   XM_007970545
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RPH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007968739   ⟸   XM_007970548
- Peptide Label: isoform X4
Ensembl Acc Id: ENSCSAP00000010510   ⟸   ENSCSAT00000012476
RefSeq Acc Id: XP_037862902   ⟸   XM_038006974
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037862903   ⟸   XM_038006975
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037862904   ⟸   XM_038006976
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012476.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CK1_Ser-Thr_kinase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene VRK2 ENTREZGENE
PANTHER CASEIN KINASE-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RPH1 ENTREZGENE, UniProtKB/TrEMBL