Vrk2 (VRK serine/threonine kinase 2)

Gene: Vrk2 (VRK serine/threonine kinase 2) Chinchilla lanigera

Analyze

Symbol:

Vrk2

Name:

VRK serine/threonine kinase 2

RGD ID:

8900569

Description:

ENCODES a protein that exhibits protein domain specific binding (ortholog); protein kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to oxidative stress (ortholog); regulation of interleukin-1-mediated signaling pathway (ortholog); regulation of MAPK cascade (ortholog); ASSOCIATED WITH epilepsy (ortholog); Fanconi anemia (ortholog); Fanconi anemia complementation group A (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein kinase VRK2; vaccinia related kinase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	25,282,007 - 25,399,348 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	25,307,221 - 25,397,900 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

Fanconi anemia (ISO)

Fanconi anemia complementation group A (ISO)

Fanconi anemia complementation group L (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxidative stress (ISO)

regulation of interleukin-1-mediated signaling pathway (ISO)

regulation of MAPK cascade (ISO)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

membrane (ISO)

mitochondrial membrane (ISO)

nuclear envelope (ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

protein binding (ISO)

protein domain specific binding (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Vrk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	25,282,007 - 25,399,348 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	25,307,221 - 25,397,900 (-)	NCBI	ChiLan1.0	ChiLan1.0

VRK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	57,907,592 - 58,159,920 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	57,907,629 - 58,159,920 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	58,134,727 - 58,387,055 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	58,127,224 - 58,240,510 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	58,185,476 - 58,298,654	NCBI
Celera	2	58,116,828 - 58,230,225 (+)	NCBI		Celera
Cytogenetic Map	2	p16.1	NCBI
HuRef	2	58,014,875 - 58,128,335 (+)	NCBI		HuRef
CHM1_1	2	58,203,888 - 58,317,318 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	57,912,292 - 58,164,754 (+)	NCBI		T2T-CHM13v2.0

Vrk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	26,421,398 - 26,544,006 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	26,421,322 - 26,543,999 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	26,471,398 - 26,594,012 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	26,471,322 - 26,593,999 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	26,371,401 - 26,493,920 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	26,503,981 - 26,625,366 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	26,371,404 - 26,493,611 (-)	NCBI		MGSCv36	mm8
Celera	11	28,995,024 - 28,995,410 (+)	NCBI		Celera
Celera	11	37,253,803 - 37,372,542 (-)	NCBI		Celera
Cytogenetic Map	11	A3.3	NCBI
cM Map	11	15.94	NCBI

Vrk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	104,514,815 - 104,635,549 (-)	NCBI		GRCr8
mRatBN7.2	14	100,313,771 - 100,434,520 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	100,313,601 - 100,434,527 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	104,646,638 - 104,767,362 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	105,890,724 - 106,011,446 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	102,362,554 - 102,483,276 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	110,739,835 - 110,883,836 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	110,739,226 - 110,883,803 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	110,554,902 - 110,576,584 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	14	110,444,503 - 110,501,306 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	107,287,844 - 107,450,960 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	107,300,490 - 107,470,542 (-)	NCBI
Celera	14	99,260,139 - 99,368,196 (-)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

VRK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	68,197,958 - 68,310,907 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	68,201,910 - 68,314,773 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	58,158,347 - 58,271,245 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	59,166,949 - 59,419,895 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	59,305,233 - 59,419,895 (+)	Ensembl	panpan1.1		panPan2

VRK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	58,432,144 - 58,544,189 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	58,431,978 - 58,544,189 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	58,280,905 - 58,497,135 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	59,332,186 - 59,547,978 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	59,435,778 - 59,547,970 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	59,029,154 - 59,244,640 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	59,313,317 - 59,529,195 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	59,606,236 - 59,821,676 (+)	NCBI		UU_Cfam_GSD_1.0

Vrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	24,418,835 - 24,615,182 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	3,958,588 - 4,057,738 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	3,956,171 - 4,057,753 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VRK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	83,433,313 - 83,536,980 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	83,435,250 - 83,537,022 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	88,020,677 - 88,122,044 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VRK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	48,803,149 - 48,909,144 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	48,798,499 - 48,906,712 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	62,835,754 - 62,944,601 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vrk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	3,663,641 - 3,776,404 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624833	3,663,606 - 3,778,598 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013514668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01025040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01025041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01356535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01354912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000024357 ⟹ ENSCLAP00000024124

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	25,282,007 - 25,399,348 (-)	Ensembl

RefSeq Acc Id:

XM_013514668 ⟹ XP_013370122

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955424	25,307,221 - 25,397,900 (-)	NCBI

Sequence:

show sequence

CGGCGCTCTCCGGCGTCTGGGCCGCGCCCTCCAGCGCCCGCGGCGCCTCCTCCCCGCCCGGCCC
GGCCCGCCCCGGTCCCTGTCCGCCTGGGCGGGGCGGGGCCGCTCAGCTTCCGCCCGCGCGAGCC
CAGCGACGGAGCCGCGGCGACACGAGGCCCGGACAGCGAGGCCGGGTCCGGCCGAAGTGATGGC
ACCCAGAAGAAATGGGAAGTACAAACTTCCTGTTCCACTTCCAGAAGGCAAGGTTCTGGATGAT
ACCGAAGGAAAACAGTGGGTACTGGGCAAGATGATTGGCTCTGGAGGATTTGGATTGATATATT
TAGCTTTCCCCACAAATAAACAAGACAGAGATGCGAGCCATGTAATAAAGGTGGAATATCAAGA
AAATGGTCCATTATTTTCAGAACTAAAATTTTATCAGAGAGCCGCAAAAAAAGACTGTATCAAA
AAGTGGATAGAACTCAAACAACTTGATTACTTAGGAATTCCTCTGTTTTATGGATCTGGTATAA
CTGAATTCAAGGGAAGAAGTTACAGGTTTATGGTAATGGAAAGATTGGGAGTAGATTTACAGAA
GCTCTCAGACCAGAATGGGACTTTTAGAAAGTCAACTGTCCTACAGTTAGGTCTCCGGATGCTG
GATGTACTGGAATATATACATGAAAATGAATATGTTCATGGTGATATAAAAGCAGCAAATCTAC
TTTTGGGTTATAAAAGTCCAGATCGGGTTTATCTTGCAGATTATGGACTTTCGTACAGATATTG
TCCCAATGGGAACCACAAACAGTATCAGGAAAATCCTAGAAAAGGCCATAATGGAACAATAGAG
TTTACTAGCTTGGATGCCCACAAGGGAGTAGCCCTGTCCAGAAGAAGCGACATTGAAATCCTCG
GCTACTGCATGCTACGGTGGTTGTGTGGGAAACTTCCTTGGGAAAAGAACCTGAAGGACCCCGT
GGCTGTCCAGACTGCTAAAACAAATCTGCTGGCTGAGCTTCCTGAGTCAGTGCTGAAGTGGGCT
CCATCTGGAAGCAGTTGCTGTGAAATAGCCCAATTTTTGTCATATGTTCATAGTTTAGCTTATG
ATGAAAAGCCAAACTATCAAAGGCTGAAGAAAATTCTAAACCCAGGTGGAGTACCTTTAGGACC
ACTGGAATTTTCGGCTAACGGACAGAGTGTAAATGTGCATACCCCAACCAATCAAAAAGTTGAT
TCAAGAAAGGCTGCAACAAGACAAGTTGATCAGATACAAAATAAGTTGAAAGAAAAAGCCCACT
CTGAGAGAAGCGCTGAGTCCTTTGCCACAGGGAGAAAAGTGCACAAAGAGGACAAGCTGATTGG
ATTGACGAACAATGAAGTAGTTCAGGGAAGCACAAGAAGGCGACAGAAATACCATGAGTCTTCA
GAACTTCTGAATGAAGTAAACAGTTTCCCCCTCAAATCTAGCTATACATACTTCCCACAGTCAC
TTTATGAACCCTATCAAGATTTTACCAGTCCAGATAAGATCACCAAGTCGCAGTCTCCACCTTG
GTATGTGTACACTTCCACAACTGGTATGGAACTCGCAGACTTACAAAGTTCTGCAGGATTTTGG
TCTACAATTTCCCAGTTTACTCTGACTGAAGAGACAAAGGCAGATGTATACTTCTACAGCTCCA
TCATATTTTTGCTTCTGATACTGGTATGTCTTGCTCTATATTTTCTTTGAAAGTATCAAATAAA
ATTCTTCTGGTAGTTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013370122	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024124
	ENSCLAP00000024124.1

RefSeq Acc Id:

XP_013370122 ⟸ XM_013514668

- UniProtKB:

A0A8C2W296 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPRRNGKYKLPVPLPEGKVLDDTEGKQWVLGKMIGSGGFGLIYLAFPTNKQDRDASHVIKVEY
QENGPLFSELKFYQRAAKKDCIKKWIELKQLDYLGIPLFYGSGITEFKGRSYRFMVMERLGVDL
QKLSDQNGTFRKSTVLQLGLRMLDVLEYIHENEYVHGDIKAANLLLGYKSPDRVYLADYGLSYR
YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDIEILGYCMLRWLCGKLPWEKNLKD
PVAVQTAKTNLLAELPESVLKWAPSGSSCCEIAQFLSYVHSLAYDEKPNYQRLKKILNPGGVPL
GPLEFSANGQSVNVHTPTNQKVDSRKAATRQVDQIQNKLKEKAHSERSAESFATGRKVHKEDKL
IGLTNNEVVQGSTRRRQKYHESSELLNEVNSFPLKSSYTYFPQSLYEPYQDFTSPDKITKSQSP
PWYVYTSTTGMELADLQSSAGFWSTISQFTLTEETKADVYFYSSIIFLLLILVCLALYFL

hide sequence

RefSeq Acc Id:

ENSCLAP00000024124 ⟸ ENSCLAT00000024357

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016561	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000024357	ENTREZGENE
	ENSCLAT00000024357.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Vrk2	ENTREZGENE
PANTHER	CASEIN KINASE-RELATED	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE VRK2	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2W296	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-21	Vrk2	VRK serine/threonine kinase 2		vaccinia related kinase 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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