KGD4 (alpha-ketoglutarate dehydrogenase subunit 4)

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Gene: KGD4 (alpha-ketoglutarate dehydrogenase subunit 4) Chlorocebus sabaeus

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Symbol:

KGD4

Name:

alpha-ketoglutarate dehydrogenase subunit 4

RGD ID:

18474353

Description:

ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); INVOLVED IN tricarboxylic acid cycle (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN oxoglutarate dehydrogenase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

28S ribosomal protein S36, mitochondrial; mitochondrial ribosomal protein S36; MRPS36

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,311,461 - 65,324,129 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666049	14,042,577 - 14,055,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2-oxoglutarate metabolic process (IEA)

tricarboxylic acid cycle (ISO)

Cellular Component

mitochondrion (IEA)

oxoglutarate dehydrogenase complex (ISO)

Molecular Function

oxoglutarate dehydrogenase (succinyl-transferring) activity (IEA)

protein-macromolecule adaptor activity (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

KGD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,311,461 - 65,324,129 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666049	14,042,577 - 14,055,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

KGD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	69,217,760 - 69,230,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	69,217,760 - 69,230,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	68,513,587 - 68,525,985 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	68,549,329 - 68,561,741 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	68,549,342 - 68,561,739	NCBI
Celera	5	65,512,825 - 65,528,390 (+)	NCBI		Celera
Cytogenetic Map	5	q13.2	NCBI
HuRef	5	65,469,537 - 65,482,195 (+)	NCBI		HuRef
CHM1_1	5	68,513,313 - 68,525,725 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	70,040,372 - 70,055,914 (+)	NCBI		T2T-CHM13v2.0

Mrps36
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,872,448 - 100,881,167 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,872,463 - 100,881,167 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	100,735,940 - 100,744,659 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	100,735,955 - 100,744,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	101,505,895 - 101,514,614 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,836,218 - 101,844,892 (-)	NCBI		MGSCv36	mm8
Celera	13	104,345,739 - 104,353,541 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	53.23	NCBI

Kgd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	33,604,611 - 33,614,988 (-)	NCBI		GRCr8
mRatBN7.2	2	31,870,549 - 31,878,335 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,870,551 - 31,880,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	39,004,585 - 39,012,399 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	37,045,627 - 37,053,481 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	31,903,759 - 31,911,592 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	30,740,620 - 30,750,916 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,739,855 - 30,748,428 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	49,899,207 - 49,909,508 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	31,530,724 - 31,538,504 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	31,451,100 - 31,490,839 (-)	NCBI
Celera	2	27,884,219 - 27,892,495 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Kgd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955446	38,161 - 50,167 (+)	NCBI	ChiLan1.0	ChiLan1.0

KGD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	44,689,561 - 44,705,131 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	42,843,883 - 42,858,731 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	44,770,401 - 44,785,945 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	46,339,397 - 46,345,053 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

KGD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	54,302,992 - 54,311,943 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	25,834,145 - 25,834,559 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	51,269,353 - 51,278,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	54,813,730 - 54,822,456 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	54,813,822 - 54,822,531 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	51,872,745 - 51,880,816 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	52,648,030 - 52,656,767 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	53,535,638 - 53,544,376 (+)	NCBI		UU_Cfam_GSD_1.0

Kgd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	191,408,431 - 191,417,382 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	344,670 - 353,871 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	345,332 - 353,828 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KGD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,386,323 - 47,405,904 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	47,386,412 - 47,405,342 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,279,820 - 51,298,746 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Kgd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624905	105,155 - 118,607 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007974692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007974692 ⟹ XP_007972883

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	4	65,311,461 - 65,324,129 (+)	NCBI
Vero_WHO_p1.0	NW_023666049	14,042,577 - 14,055,073 (+)	NCBI

Sequence:

show sequence

GCGACGTCCCGAGAAGCACCGCCCCCAGCCGCCCGGGACTCCGGTGATCGCCGCGGCTCGCTCG
CGCCCCGGAAACTGCCCCTTCTAGGGGTCATGATGGGCAGCAAGATGGCGTCTGCCAGTAGGGT
CGTTCAGGTAGTCAAACCACACACTCCATTAATAAGGTTTCCTGACAGAAGAGACAATCCTAAA
CCCAATGTATCGGAAGCTTTGAGATCAGCAGGGCTACCATCTCACTCTTCTGTAATTTCACAAC
ATTCTAAGGGAAGTAAATCACCAGATTTGTTGATGTATCAGGGTCCACCAGATACTGCAGAAAT
AATAAAAACATTACCTCAGAAATACAGAAGGAAACTTGTGTCTCAAGAAGAAATTGAATTTATC
CAACGTGGAGGTCCTGAATAACCATGGTGGCTGCTGTTTGTCATCAGACAATAGAATTGTCTTT
ACAATAAAGGACTTCCAAAACGACAGATGAGAAACTGTATATTAAACACCTTTAATAAATACTA
TGAAAAAAATGAAATATAGAAAATTTAGATGGACACTTGTATTTCCTAATTTATGTATCTTGGT
CAGCTTCTCCACAAGCTTACCTAATTATTTATACACTTTATACTTATTAAAGTATACATTTTTA
AATGTTAGCCTATTAATTTACTCTTGATTATCAAACATTACCAGTGTTGAACTATTAAAAGTAC
ATAATGTATAGTAAACTATCATAGGATTCTTATAATTTCACTTTTCCTTCTTTTTAGATATGGA
AAAATTTATCAGTCAGAATTGCTGTTTTAGGTACATGATTTTCCTGAAATTGGGTGAGGATCAG
TGAAATAATGACTCTATTACTTGTTCTTAATTCTCTGTTCTCTAATGTTTTTTCATTCACAAGT
TTACTGGAGTGTAACTGGCTTAGTAAGTATATCCTACTCTGAATGATAAAAAATATAGTCAAGC
TAAAATAGGTGACTATACTATTAAGATAGAGGAGATCATACAAAAGGTTCCAAGAAAGTCAAAG
AGTATAAAATGGAAAATAAGAGACCAAATGAATATAGCATAGGAATAAAGATTTCACTAGAAAT
TGCAATTTATTTTGTTTCGGAGGTTGTAAGGAAGTCTTGTTCTTTGGTTTATTTTACTGTTTTG
TGATCTTGTATGCAAATCCTGGTAACCATTAACTTTCTCAAACTTAATGTCTCAAAGCCTCATA
AAATCAACATAAATATTTACTTATTAAGCAGTTTATGAAACTTTAATGGGGCCCCTCCTGTGCC
AAGGGTATGTGTATTATGAAGTAAAACCTCACAAAGCTAAATAAATTCTCTTCCATACCTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007972883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000018020.1

RefSeq Acc Id:	XP_007972883 ⟸ XM_007974692
- UniProtKB:	A0A0D9SAY1 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018481	UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000018571.1	UniProtKB/TrEMBL
InterPro	Kgd4/YMR-31	UniProtKB/TrEMBL
NCBI Gene	MRPS36	ENTREZGENE
PANTHER	28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL	UniProtKB/TrEMBL
	28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	S36_mt	UniProtKB/TrEMBL
UniProt	A0A0D9SAY1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-10-03	KGD4	alpha-ketoglutarate dehydrogenase subunit 4	MRPS36	mitochondrial ribosomal protein S36	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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