KGD4 (alpha-ketoglutarate dehydrogenase subunit 4)

Gene: KGD4 (alpha-ketoglutarate dehydrogenase subunit 4) Sus scrofa

Analyze

Symbol:

KGD4 (Ensembl: MRPS36)

Name:

alpha-ketoglutarate dehydrogenase subunit 4 (Ensembl:mitochondrial ribosomal protein S36)

RGD ID:

14107097

Description:

ENCODES a protein that exhibits oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN 2-oxoglutarate metabolic process (inferred); tricarboxylic acid cycle (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN oxoglutarate dehydrogenase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

28S ribosomal protein S36, mitochondrial; mitochondrial ribosomal protein S36; MRPS36

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,386,323 - 47,405,904 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	47,386,412 - 47,405,342 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,279,820 - 51,298,746 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2-oxoglutarate metabolic process (IEA)

tricarboxylic acid cycle (IEA)

Cellular Component

mitochondrion (IEA)

oxoglutarate dehydrogenase complex (ISO)

ribosome (IEA)

Molecular Function

oxoglutarate dehydrogenase (succinyl-transferring) activity (IEA)

protein-macromolecule adaptor activity (IEA)

References

Additional References at PubMed

PMID:15679890	PMID:30032202

Genomics

Comparative Map Data

KGD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,386,323 - 47,405,904 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	47,386,412 - 47,405,342 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,279,820 - 51,298,746 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KGD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	69,217,760 - 69,230,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	69,217,760 - 69,230,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	68,513,587 - 68,525,985 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	68,549,329 - 68,561,741 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	68,549,342 - 68,561,739	NCBI
Celera	5	65,512,825 - 65,528,390 (+)	NCBI		Celera
Cytogenetic Map	5	q13.2	NCBI
HuRef	5	65,469,537 - 65,482,195 (+)	NCBI		HuRef
CHM1_1	5	68,513,313 - 68,525,725 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	70,040,372 - 70,055,914 (+)	NCBI		T2T-CHM13v2.0

Mrps36
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,872,448 - 100,881,167 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,872,463 - 100,881,167 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	100,735,940 - 100,744,659 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	100,735,955 - 100,744,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	101,505,895 - 101,514,614 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,836,218 - 101,844,892 (-)	NCBI		MGSCv36	mm8
Celera	13	104,345,739 - 104,353,541 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	53.23	NCBI

Kgd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	33,604,611 - 33,614,988 (-)	NCBI		GRCr8
mRatBN7.2	2	31,870,549 - 31,878,335 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,870,551 - 31,880,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	39,004,585 - 39,012,399 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	37,045,627 - 37,053,481 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	31,903,759 - 31,911,592 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	30,740,620 - 30,750,916 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,739,855 - 30,748,428 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	49,899,207 - 49,909,508 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	31,530,724 - 31,538,504 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	31,451,100 - 31,490,839 (-)	NCBI
Celera	2	27,884,219 - 27,892,495 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Kgd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955446	38,161 - 50,167 (+)	NCBI	ChiLan1.0	ChiLan1.0

KGD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	44,689,561 - 44,705,131 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	42,843,883 - 42,858,731 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	44,770,401 - 44,785,945 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	46,339,397 - 46,345,053 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

KGD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	54,302,992 - 54,311,943 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	25,834,145 - 25,834,559 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	51,269,353 - 51,278,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	54,813,730 - 54,822,456 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	54,813,822 - 54,822,531 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	51,872,745 - 51,880,816 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	52,648,030 - 52,656,767 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	53,535,638 - 53,544,376 (+)	NCBI		UU_Cfam_GSD_1.0

Kgd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	191,408,431 - 191,417,382 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	344,670 - 353,871 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	345,332 - 353,828 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KGD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,311,461 - 65,324,129 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666049	14,042,577 - 14,055,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kgd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624905	105,155 - 118,607 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in KGD4
370 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	10	4	3	5	2	23	2	3	3
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003134022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP085444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01039903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000044903 ⟹ ENSSSCP00000052261

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	16	47,386,323 - 47,405,904 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000069523 ⟹ ENSSSCP00000068456

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	16	47,400,827 - 47,405,904 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000077633 ⟹ ENSSSCP00000070012

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	16	47,386,460 - 47,404,756 (+)	Ensembl

RefSeq Acc Id:

XM_003134022 ⟹ XP_003134070

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	16	47,386,412 - 47,405,342 (+)	NCBI

Sequence:

show sequence

AGTGACGTCACTTGCAGGGCCCGCCCCCAGCCGCCCAGGACTCCTGATATAGCCGCTGCTAGCT
AGTGCTCCGGAAGCTGCCCCTCCTCGGGGGTCATGATGGGCAGTAAGATGGCGTCTGCCAGCAG
GGTCGTTCAGGTAGTCAAGCCACATACTCCATTAATAAGGTTCCCAGACAGAAGAGACAATCCT
AAACCCAATGTATCAGAAGTTTTGAGATCAGCAGCACTACCATCTCACCCTTCAATTTCACAGC
ATTCTAAGGGAAGTAAATCGCCAGACTGGCTGAAGCATCAGGGTCCACCAGACACTGCAGAGAT
AATAAAAACATTACCTCAGAAATACAGAAGGAAACTTGTGTCTCAGGAAGAAATGGAATTTATC
CAACGTGGAGGTCCAGAATAATTACTACCAATGTGGCTGCTGTTTGTCATCAAACAAAAGAATA
GTCTTTACATTAGAGGACTTCAGAATGACAGATGAAAAATTGTACATTAAGCAACTTTAATAAA
TACTCTGTAAAAAAAGAAAATGAAGTATAGAAAATTTAGATGGACACTTATATCTCCTAATTTA
TGTATCTGGGTCAGCTTCTCCACAAGCTTACCTAATTGTTTATATACTTTATACTTATTAAAGT
ATACATTTTTAAATGTTAGCCTATTAATTTACTCTTGATTATCAAGCATTACAGTGTTGAACTA
TTAAAAGCACACAATGTCTACTGAAGTATCATAGGTTTCCTATAATTTTACTTTTCTTTCAATT
TCTGTTTAAACATGGAAAGAATATCAGGCAGAATTGTAGCTTTCTGGGAAGTAATCTTCCTGAA
ATTGAAGGAGGATCAGTGAAATAATGACTCCATTATTTGTTCTTAACTCTCTTAATATTTTTGC
ATTCACAGAGTTAAACTGAAATATAACCAGCTTAATAAGCATATGGTACTCTAAATGATAAAAA
TATAGCCAAAGTAAAACAGGTGGCTTTGTGGTATTAAGACTAAGGAGTTAACACAAAAGATTAT
TTGTAACCTATATTCAGAAAAAAAATGTCAGTAGTTAAAATGGAAAATAAGAGATCAAAATGAA
TATAACATAGGAATAATGTTTGACCAGAAACTGCTTTTGTTTCTAGGGATGTTAAGAAAGTCTT
GTTCTTTGGTTTATTTTACTGTTTTGATTGTGATCATGTATATGAATCCTGATAATCATAAAAC
TTTCTCAAACTTATTGAAAACCTCATAAAATTAACCTATTTACCTTTTTATGCAATTTATGCAA
TTTTAATAGGGTCTTCCTTTGCCAAGGGTATGTATTATTGTGAAAGTAAAGCCTCACAAAGTGA
AATAAATTCTACTGCATACCTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003134070	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000052261.2
	ENSSSCP00000068456.1
	ENSSSCP00005024031.1
	ENSSSCP00005024056.1
	ENSSSCP00005024083.1
	ENSSSCP00015024793.1
	ENSSSCP00025026001.1
	ENSSSCP00030028273.1
	ENSSSCP00035019361.1
	ENSSSCP00040038533.1
	ENSSSCP00045016709.1
	ENSSSCP00050032128.1
	ENSSSCP00055031714.1
	ENSSSCP00060017687.1
	ENSSSCP00065045614.1
	ENSSSCP00070028714.1

RefSeq Acc Id:	XP_003134070 ⟸ XM_003134022
- UniProtKB:	A0A4X1UK37 (UniProtKB/TrEMBL), A0A480SMQ1 (UniProtKB/TrEMBL), A0A8D0NVV3 (UniProtKB/TrEMBL), A0A8D0S3P5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMGSKMASASRVVQVVKPHTPLIRFPDRRDNPKPNVSEVLRSAALPSHPSISQHSKGSKSPDWL KHQGPPDTAEIIKTLPQKYRRKLVSQEEMEFIQRGGPE hide sequence

RefSeq Acc Id:

ENSSSCP00000052261 ⟸ ENSSSCT00000044903

RefSeq Acc Id:

ENSSSCP00000068456 ⟸ ENSSSCT00000069523

RefSeq Acc Id:

ENSSSCP00000070012 ⟸ ENSSSCT00000077633

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000037463	Ensembl, UniProtKB/TrEMBL
	ENSSSCG00005024633	UniProtKB/TrEMBL
	ENSSSCG00015046256	UniProtKB/TrEMBL
	ENSSSCG00025045098	UniProtKB/TrEMBL
	ENSSSCG00030044332	UniProtKB/TrEMBL
	ENSSSCG00035036517	UniProtKB/TrEMBL
	ENSSSCG00040064210	UniProtKB/TrEMBL
	ENSSSCG00045014224	UniProtKB/TrEMBL
	ENSSSCG00050054622	UniProtKB/TrEMBL
	ENSSSCG00055020337	UniProtKB/TrEMBL
	ENSSSCG00060030809	UniProtKB/TrEMBL
	ENSSSCG00065074915	UniProtKB/TrEMBL
	ENSSSCG00070017415	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000044903.3	UniProtKB/TrEMBL
	ENSSSCT00000069523.2	UniProtKB/TrEMBL
	ENSSSCT00005039140.1	UniProtKB/TrEMBL
	ENSSSCT00005039187.1	UniProtKB/TrEMBL
	ENSSSCT00005039243.1	UniProtKB/TrEMBL
	ENSSSCT00015061726.1	UniProtKB/TrEMBL
	ENSSSCT00025061223.1	UniProtKB/TrEMBL
	ENSSSCT00030061832.1	UniProtKB/TrEMBL
	ENSSSCT00035048406.1	UniProtKB/TrEMBL
	ENSSSCT00040087700.1	UniProtKB/TrEMBL
	ENSSSCT00045024225.1	UniProtKB/TrEMBL
	ENSSSCT00050074500.1	UniProtKB/TrEMBL
	ENSSSCT00055039881.1	UniProtKB/TrEMBL
	ENSSSCT00060041647.1	UniProtKB/TrEMBL
	ENSSSCT00065103251.1	UniProtKB/TrEMBL
	ENSSSCT00070034372.1	UniProtKB/TrEMBL
InterPro	Ribosomal_S36_mt	UniProtKB/TrEMBL
KEGG Report	ssc:100516116	UniProtKB/TrEMBL
NCBI Gene	MRPS36	ENTREZGENE
PANTHER	28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR31601	UniProtKB/TrEMBL
UniProt	A0A480SMQ1	ENTREZGENE
	A0A4X1UK37	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0NVV3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0S3P5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1KI85_PIG	UniProtKB/TrEMBL
	A0A8D1N461_PIG	UniProtKB/TrEMBL
UniProt Secondary	A0A287B719	UniProtKB/TrEMBL
	A0A480SMQ1	UniProtKB/TrEMBL
	A0A5G2QU45	UniProtKB/TrEMBL
	A0A5G2R7A6	UniProtKB/TrEMBL
VGNC ID	VGNC:90397	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-10-02	KGD4	alpha-ketoglutarate dehydrogenase subunit 4	MRPS36	mitochondrial ribosomal protein S36	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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