PRUNE1 (prune exopolyphosphatase 1) - Rat Genome Database

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Gene: PRUNE1 (prune exopolyphosphatase 1) Chlorocebus sabaeus
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Symbol: PRUNE1
Name: prune exopolyphosphatase 1
RGD ID: 18474224
Description: ENCODES a protein that exhibits exopolyphosphatase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN regulation of microtubule polymerization (inferred); regulation of neurogenesis (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); immunodeficiency 42 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: exopolyphosphatase PRUNE1; protein prune homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,241,883 - 12,273,052 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRUNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,241,883 - 12,273,052 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRUNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,008,449 - 151,035,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,008,420 - 151,035,713 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,980,925 - 151,008,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,247,597 - 149,274,813 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,794,045 - 147,821,262NCBI
Celera1124,096,668 - 124,123,871 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,357,970 - 122,385,385 (+)NCBIHuRef
CHM1_11152,376,283 - 152,403,499 (+)NCBICHM1_1
T2T-CHM13v2.01150,132,139 - 150,159,408 (+)NCBIT2T-CHM13v2.0
Prune1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,160,985 - 95,190,817 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,160,985 - 95,189,387 (-)EnsemblGRCm39 Ensembl
GRCm38395,253,674 - 95,283,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,253,674 - 95,282,076 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,057,596 - 95,085,998 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,339,078 - 95,367,480 (-)NCBIMGSCv36mm8
Celera396,684,727 - 96,713,378 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Prune1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,519,569 - 185,548,402 (-)NCBIGRCr8
mRatBN7.22182,830,575 - 182,859,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,830,578 - 182,859,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,497,112 - 190,524,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,292,694 - 188,320,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,129,602 - 183,157,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,427,714 - 196,457,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,427,710 - 196,456,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,924,545 - 215,954,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,165,356 - 190,192,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,128,110 - 190,155,561 (-)NCBI
Celera2175,365,417 - 175,393,016 (-)NCBICelera
Cytogenetic Map2q34NCBI
Prune1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588382,425 - 407,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955588379,793 - 408,441 (+)NCBIChiLan1.0ChiLan1.0
PRUNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,797,633 - 98,825,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,551,837 - 98,579,192 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,357,779 - 126,385,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,006,097 - 130,032,985 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,006,097 - 130,032,985 (+)Ensemblpanpan1.1panPan2
PRUNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,104,724 - 60,125,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,104,958 - 60,124,900 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,548,767 - 59,569,497 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,120,790 - 61,141,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,120,849 - 61,144,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,949,871 - 59,970,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,034,762 - 60,055,697 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,762,292 - 60,783,225 (+)NCBIUU_Cfam_GSD_1.0
Prune1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,200,841 - 22,223,304 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,230,820 - 1,254,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,231,197 - 1,253,686 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRUNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,194,139 - 98,216,932 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,194,138 - 98,218,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,447,181 - 107,470,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Prune1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,791,590 - 18,816,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,791,590 - 18,820,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 34 20
Low 2 20 40
Below cutoff

Sequence


RefSeq Acc Id: XM_008019310   ⟹   XP_008017501
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,273,052 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008019311   ⟹   XP_008017502
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,272,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037997980   ⟹   XP_037853908
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,272,438 (-)NCBI
RefSeq Acc Id: XM_037997981   ⟹   XP_037853909
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,272,432 (-)NCBI
RefSeq Acc Id: XM_037997982   ⟹   XP_037853910
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,272,446 (-)NCBI
RefSeq Acc Id: XM_037997983   ⟹   XP_037853911
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603812,241,883 - 12,262,980 (-)NCBI
RefSeq Acc Id: XP_008017501   ⟸   XM_008019310
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RZJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037853910   ⟸   XM_037997982
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037853908   ⟸   XM_037997980
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037853909   ⟸   XM_037997981
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008017502   ⟸   XM_008019311
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037853911   ⟸   XM_037997983
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018020 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016117.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.310.20 UniProtKB/TrEMBL
  inorganic pyrophosphatase (n-terminal core) UniProtKB/TrEMBL
InterPro DDH_dom UniProtKB/TrEMBL
  DHH_sf UniProtKB/TrEMBL
  DHHA2 UniProtKB/TrEMBL
  DHHA2_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103247214 UniProtKB/TrEMBL
NCBI Gene PRUNE1 ENTREZGENE
PANTHER BNIP - RELATED UniProtKB/TrEMBL
  EXOPOLYPHOSPHATASE PRUNE1 UniProtKB/TrEMBL
Pfam DHH UniProtKB/TrEMBL
  DHHA2 UniProtKB/TrEMBL
SMART DHHA2 UniProtKB/TrEMBL
Superfamily-SCOP SSF64182 UniProtKB/TrEMBL
UniProt A0A0D9RZJ9 ENTREZGENE, UniProtKB/TrEMBL