Prune1 (prune exopolyphosphatase 1) - Rat Genome Database

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Gene: Prune1 (prune exopolyphosphatase 1) Heterocephalus glaber
Analyze
Symbol: Prune1
Name: prune exopolyphosphatase 1
RGD ID: 18928460
Description: ENCODES a protein that exhibits phosphatase activity (ortholog); tubulin binding (ortholog); INVOLVED IN regulation of microtubule polymerization (ortholog); regulation of neurogenesis (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); immunodeficiency 42 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: exopolyphosphatase PRUNE1; protein prune homolog; PRUNE; prune-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,791,590 - 18,816,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,791,590 - 18,820,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prune1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,791,590 - 18,816,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,791,590 - 18,820,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PRUNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,008,449 - 151,035,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,008,420 - 151,035,713 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,980,925 - 151,008,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,247,597 - 149,274,813 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,794,045 - 147,821,262NCBI
Celera1124,096,668 - 124,123,871 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,357,970 - 122,385,385 (+)NCBIHuRef
CHM1_11152,376,283 - 152,403,499 (+)NCBICHM1_1
T2T-CHM13v2.01150,132,139 - 150,159,408 (+)NCBIT2T-CHM13v2.0
Prune1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,160,985 - 95,190,817 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,160,985 - 95,189,387 (-)EnsemblGRCm39 Ensembl
GRCm38395,253,674 - 95,283,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,253,674 - 95,282,076 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,057,596 - 95,085,998 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,339,078 - 95,367,480 (-)NCBIMGSCv36mm8
Celera396,684,727 - 96,713,378 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Prune1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,519,569 - 185,548,402 (-)NCBIGRCr8
mRatBN7.22182,830,575 - 182,859,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,830,578 - 182,859,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,497,112 - 190,524,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,292,694 - 188,320,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,129,602 - 183,157,163 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,427,714 - 196,457,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,427,710 - 196,456,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,924,545 - 215,954,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,165,356 - 190,192,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,128,110 - 190,155,561 (-)NCBI
Celera2175,365,417 - 175,393,016 (-)NCBICelera
Cytogenetic Map2q34NCBI
Prune1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588382,425 - 407,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955588379,793 - 408,441 (+)NCBIChiLan1.0ChiLan1.0
PRUNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,797,633 - 98,825,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,551,837 - 98,579,192 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,357,779 - 126,385,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,006,097 - 130,032,985 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,006,097 - 130,032,985 (+)Ensemblpanpan1.1panPan2
PRUNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,104,724 - 60,125,899 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,104,958 - 60,124,900 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,548,767 - 59,569,497 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,120,790 - 61,141,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,120,849 - 61,144,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,949,871 - 59,970,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,034,762 - 60,055,697 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,762,292 - 60,783,225 (+)NCBIUU_Cfam_GSD_1.0
Prune1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,200,841 - 22,223,304 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,230,820 - 1,254,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,231,197 - 1,253,686 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRUNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,194,139 - 98,216,932 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,194,138 - 98,218,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,447,181 - 107,470,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRUNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,241,883 - 12,273,052 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000013942   ⟹   ENSHGLP00000013801
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477218,791,590 - 18,816,679 (-)Ensembl
RefSeq Acc Id: XM_004854039   ⟹   XP_004854096
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,596 - 18,817,335 (-)NCBI
RefSeq Acc Id: XM_013075534   ⟹   XP_012930988
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,820,818 (-)NCBI
RefSeq Acc Id: XM_013075538   ⟹   XP_012930992
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,808,988 (-)NCBI
RefSeq Acc Id: XM_013075539   ⟹   XP_012930993
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,801,383 (-)NCBI
RefSeq Acc Id: XM_013075540   ⟹   XP_012930994
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,807,757 (-)NCBI
RefSeq Acc Id: XM_021265913   ⟹   XP_021121572
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,596 - 18,816,573 (-)NCBI
RefSeq Acc Id: XM_021265914   ⟹   XP_021121573
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,596 - 18,816,573 (-)NCBI
RefSeq Acc Id: XM_021265915   ⟹   XP_021121574
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,596 - 18,816,631 (-)NCBI
RefSeq Acc Id: XM_021265916   ⟹   XP_021121575
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,815,834 (-)NCBI
RefSeq Acc Id: XM_021265917   ⟹   XP_021121576
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477218,791,590 - 18,816,622 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012930988   ⟸   XM_013075534
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121576   ⟸   XM_021265917
- Peptide Label: isoform X5
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121575   ⟸   XM_021265916
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012930992   ⟸   XM_013075538
- Peptide Label: isoform X6
RefSeq Acc Id: XP_012930994   ⟸   XM_013075540
- Peptide Label: isoform X8
RefSeq Acc Id: XP_012930993   ⟸   XM_013075539
- Peptide Label: isoform X7
RefSeq Acc Id: XP_004854096   ⟸   XM_004854039
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121574   ⟸   XM_021265915
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121573   ⟸   XM_021265914
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021121572   ⟸   XM_021265913
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J4B1 (UniProtKB/TrEMBL),   G5AJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000013801   ⟸   ENSHGLT00000013942


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009857 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000013942 ENTREZGENE
Gene3D-CATH DHHA2 domain UniProtKB/TrEMBL
  inorganic pyrophosphatase (n-terminal core) UniProtKB/TrEMBL
InterPro DDH_dom UniProtKB/TrEMBL
  DHH_sf UniProtKB/TrEMBL
  DHHA2 UniProtKB/TrEMBL
  DHHA2_dom_sf UniProtKB/TrEMBL
NCBI Gene Prune1 ENTREZGENE
PANTHER BNIP - RELATED UniProtKB/TrEMBL
  EXOPOLYPHOSPHATASE PRUNE1 UniProtKB/TrEMBL
Pfam DHH UniProtKB/TrEMBL
  DHHA2 UniProtKB/TrEMBL
SMART DHHA2 UniProtKB/TrEMBL
Superfamily-SCOP DHH phosphoesterases UniProtKB/TrEMBL
UniProt A0A0P6J4B1 ENTREZGENE, UniProtKB/TrEMBL
  G5AJY5 ENTREZGENE, UniProtKB/TrEMBL