DUSP18 (dual specificity phosphatase 18) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: DUSP18 (dual specificity phosphatase 18) Chlorocebus sabaeus
Analyze
Symbol: DUSP18
Name: dual specificity phosphatase 18
RGD ID: 18448150
Description: ENCODES a protein that exhibits calmodulin-dependent protein phosphatase activity (inferred); histone H2AXS140 phosphatase activity (inferred); histone H2AXY142 phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); peptidyl-threonine dephosphorylation (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); FOUND IN cytoplasm (inferred); mitochondrial inner membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity protein phosphatase 18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,542,987 - 13,549,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045112,576,644 - 112,585,080 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DUSP18Green Monkeychromatin remodeling involved_inIEAGO:0140791 and GO:0140793150520179 GOCGO_REF:0000108
DUSP18Green Monkeydephosphorylation involved_inISODUSP18 (Homo sapiens)9068941 PMID:24531476UniProtPMID:24531476
DUSP18Green Monkeypeptidyl-threonine dephosphorylation involved_inISODUSP18 (Homo sapiens)9068941 PMID:12591617UniProtPMID:12591617
DUSP18Green Monkeypeptidyl-tyrosine dephosphorylation involved_inISODUSP18 (Homo sapiens)9068941 PMID:12408986 and PMID:12591617UniProtPMID:12408986 and PMID:12591617
DUSP18Green Monkeyregulation of transcription by RNA polymerase II involved_inIEAGO:0180004150520179 GOCGO_REF:0000108

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DUSP18Green Monkeycytoplasm located_inIEAPANTHER:PTN000017486150520179 TreeGrafterGO_REF:0000118
DUSP18Green Monkeycytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
DUSP18Green Monkeycytoplasm located_inIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green Monkeymitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
DUSP18Green Monkeymitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
DUSP18Green Monkeymitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
DUSP18Green Monkeynucleoplasm located_inIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green Monkeynucleus located_inIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
DUSP18Green Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
1 to 10 of 10 rows

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DUSP18Green Monkeycalmodulin-dependent protein phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green Monkeyhistone H2AXS140 phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green Monkeyhistone H2AXY142 phosphatase activity enablesIEAEC:3.1.3.48150520179 UniProtGO_REF:0000003
DUSP18Green MonkeyMAP kinase serine/threonine phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green MonkeyMAP kinase tyrosine/serine/threonine phosphatase activity enablesIEAInterPro:IPR020420150520179 InterProGO_REF:0000002
DUSP18Green Monkeymyosin phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green Monkeynon-membrane spanning protein tyrosine phosphatase activity enablesIEAEC:3.1.3.48150520179 UniProtGO_REF:0000003
DUSP18Green Monkeyphosphatase activity enablesIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green Monkeyphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-0904150520179 UniProtGO_REF:0000043
DUSP18Green Monkeyphosphoprotein phosphatase activity enablesIEAARBA:ARBA00027651150520179 UniProtGO_REF:0000117
DUSP18Green Monkeyprotein binding enablesISOUniProtKB:P062139068941 PMID:28065597IntActPMID:28065597
DUSP18Green Monkeyprotein binding enablesISOUniProtKB:Q8WXH29068941 PMID:32814053IntActPMID:32814053
DUSP18Green Monkeyprotein tyrosine phosphatase activity enablesIEAPANTHER:PTN000017486150520179 TreeGrafterGO_REF:0000118
DUSP18Green Monkeyprotein tyrosine phosphatase activity enablesIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green Monkeyprotein tyrosine phosphatase activity, metal-dependent enablesIEAEC:3.1.3.48150520179 UniProtGO_REF:0000003
DUSP18Green Monkeyprotein tyrosine/serine/threonine phosphatase activity enablesIEAUniProtKB:Q8NEJ0 and ensembl:ENSP00000333917150520179 EnsemblGO_REF:0000107
DUSP18Green MonkeyRNA polymerase II CTD heptapeptide repeat S2 phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green MonkeyRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green MonkeyRNA polymerase II CTD heptapeptide repeat S7 phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
DUSP18Green MonkeyRNA polymerase II CTD heptapeptide repeat T4 phosphatase activity enablesIEAEC:3.1.3.16150520179 UniProtGO_REF:0000003
1 to 20 of 21 rows

PMID:22301074  



DUSP18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,542,987 - 13,549,157 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045112,576,644 - 112,585,080 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DUSP18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,652,051 - 30,667,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,652,051 - 30,667,887 (-)EnsemblGRCh38hg38GRCh38
GRCh372231,048,038 - 31,063,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,388,039 - 29,393,872 (-)NCBINCBI36Build 36hg18NCBI36
Build 342229,382,592 - 29,388,426NCBI
Celera2214,858,124 - 14,863,957 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,020,248 - 14,026,079 (-)NCBIHuRef
CHM1_12231,017,743 - 31,023,575 (-)NCBICHM1_1
T2T-CHM13v2.02231,115,603 - 31,131,414 (-)NCBIT2T-CHM13v2.0
Dusp18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,844,940 - 3,851,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,845,240 - 3,851,296 (+)EnsemblGRCm39 Ensembl
GRCm38113,894,935 - 3,901,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,895,240 - 3,901,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,795,243 - 3,801,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,795,284 - 3,801,299 (+)NCBIMGSCv36mm8
Celera114,388,963 - 4,395,825 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.74NCBI
Dusp18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,013,850 - 83,035,168 (+)NCBIGRCr8
mRatBN7.21478,790,183 - 78,811,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,787,505 - 78,811,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,231,297 - 83,237,917 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,471,379 - 84,477,999 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,917,014 - 80,923,636 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,150,484 - 84,169,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,150,908 - 84,157,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,834,633 - 84,851,316 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,555,975 - 84,560,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,575,119 - 84,579,510 (+)NCBI
Celera1477,702,267 - 77,708,887 (+)NCBICelera
Cytogenetic Map14q21NCBI
Dusp18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,899,090 - 4,906,785 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,899,090 - 4,906,785 (-)NCBIChiLan1.0ChiLan1.0
DUSP18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,609,377 - 40,625,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,307,833 - 43,323,692 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,678,146 - 11,693,956 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,478,686 - 29,494,499 (-)NCBIpanpan1.1PanPan1.1panPan2
DUSP18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,732,015 - 23,739,496 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,590,754 - 23,610,230 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,104,279 - 24,123,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,117,275 - 24,124,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,805,692 - 23,825,165 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,068,322 - 24,087,806 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,128,911 - 24,148,385 (-)NCBIUU_Cfam_GSD_1.0
DUSP18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,536,202 - 47,550,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,534,152 - 47,550,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,651,790 - 50,655,366 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Dusp18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247477,046,143 - 7,053,197 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in DUSP18
182 total Variants





RefSeq Transcripts XM_007975426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_007975426   ⟹   XP_007973617
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11913,542,987 - 13,549,157 (-)NCBI
Vero_WHO_p1.0NW_023666045112,576,644 - 112,585,080 (+)NCBI
Sequence:
Protein RefSeqs XP_007973617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005416.1
RefSeq Acc Id: XP_007973617   ⟸   XM_007975426
- UniProtKB: A0A0D9R9X7 (UniProtKB/TrEMBL)



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000009166 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007230.1 UniProtKB/TrEMBL
Gene3D-CATH Protein tyrosine phosphatase superfamily UniProtKB/TrEMBL
InterPro Atypical_DUSP_subfamB UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
NCBI Gene DUSP18 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 18 UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 21 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  ADSPHPHTASEB UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP (Phosphotyrosine protein) phosphatases II UniProtKB/TrEMBL
UniProt A0A0D9R9X7 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows