Dusp18 (dual specificity phosphatase 18) - Rat Genome Database

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Gene: Dusp18 (dual specificity phosphatase 18) Mus musculus
Analyze
Symbol: Dusp18
Name: dual specificity phosphatase 18
RGD ID: 1315822
MGI Page MGI
Description: Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein targeting to membrane; protein targeting to mitochondrion; and response to antibiotic. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and nucleoplasm. Predicted to be extrinsic component of mitochondrial inner membrane and intrinsic component of mitochondrial inner membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human DUSP18 (dual specificity phosphatase 18).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930527G07Rik; AI430870; BB028064; DSP; DSP18; dual specificity protein phosphatase 18; DUSP; DUSP20; LMWDS; LMWDSP20; low molecular weight dual specificity phosphatase 20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,844,940 - 3,851,299 (+)NCBIGRCm39mm39
GRCm39 Ensembl113,845,240 - 3,851,296 (+)Ensembl
GRCm38113,894,935 - 3,901,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,895,240 - 3,901,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,795,243 - 3,801,299 (+)NCBIGRCm37mm9NCBIm37
MGSCv36113,795,284 - 3,801,299 (+)NCBImm8
Celera114,388,963 - 4,395,825 (+)NCBICelera
Cytogenetic Map11A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17976645  
PMID:18385140   PMID:21267068  


Genomics

Comparative Map Data
Dusp18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,844,940 - 3,851,299 (+)NCBIGRCm39mm39
GRCm39 Ensembl113,845,240 - 3,851,296 (+)Ensembl
GRCm38113,894,935 - 3,901,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,895,240 - 3,901,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37113,795,243 - 3,801,299 (+)NCBIGRCm37mm9NCBIm37
MGSCv36113,795,284 - 3,801,299 (+)NCBImm8
Celera114,388,963 - 4,395,825 (+)NCBICelera
Cytogenetic Map11A1NCBI
DUSP18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,652,051 - 30,667,887 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,652,051 - 30,667,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,048,038 - 31,063,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,388,039 - 29,393,872 (-)NCBINCBI36hg18NCBI36
Build 342229,382,592 - 29,388,426NCBI
Celera2214,858,124 - 14,863,957 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,020,248 - 14,026,079 (-)NCBIHuRef
CHM1_12231,017,743 - 31,023,575 (-)NCBICHM1_1
Dusp18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21478,790,183 - 78,811,576 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1478,787,505 - 78,811,576 (+)Ensembl
Rnor_6.01484,150,484 - 84,169,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,150,908 - 84,157,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,834,633 - 84,851,316 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,555,975 - 84,560,365 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,575,119 - 84,579,510 (+)NCBI
Celera1477,702,267 - 77,708,887 (+)NCBICelera
Cytogenetic Map14q21NCBI
Dusp18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,899,090 - 4,906,785 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,899,090 - 4,906,785 (-)NCBIChiLan1.0ChiLan1.0
DUSP18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,478,686 - 29,494,499 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02211,678,146 - 11,693,956 (-)NCBIMhudiblu_PPA_v0panPan3
DUSP18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,732,015 - 23,739,496 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,590,754 - 23,610,230 (-)NCBI
ROS_Cfam_1.02624,104,279 - 24,123,767 (-)NCBI
ROS_Cfam_1.0 Ensembl2624,117,275 - 24,124,047 (-)Ensembl
UMICH_Zoey_3.12623,805,692 - 23,825,165 (-)NCBI
UNSW_CanFamBas_1.02624,068,322 - 24,087,806 (-)NCBI
UU_Cfam_GSD_1.02624,128,911 - 24,148,385 (-)NCBI
DUSP18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,536,198 - 47,550,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,534,152 - 47,550,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,651,790 - 50,655,366 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,542,987 - 13,549,157 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045112,576,644 - 112,585,080 (+)NCBIVero_WHO_p1.0
Dusp18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247477,046,143 - 7,053,197 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BB028064  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,901,112 - 3,901,212UniSTSGRCm38
MGSCv37113,801,115 - 3,801,215UniSTSGRCm37
Celera114,395,641 - 4,395,741UniSTS
Cytogenetic Map11A1UniSTS
Whitehead/MRC_RH117.22UniSTS
AI430870  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,897,671 - 3,897,750UniSTSGRCm38
MGSCv37113,797,674 - 3,797,753UniSTSGRCm37
Celera114,392,199 - 4,392,278UniSTS
Cytogenetic Map11A1UniSTS
Whitehead/MRC_RH1111.97UniSTS
Dusp18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS
UniSTS:236508  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,897,576 - 3,897,974UniSTSGRCm38
MGSCv37113,797,579 - 3,797,977UniSTSGRCm37
Celera114,392,104 - 4,392,502UniSTS
Cytogenetic Map11A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123930487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11126026374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11126026374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11126026374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1127705234277232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11272035536721472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11330000018200000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11330000018500000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11330000019800000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11330000034600000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11330000044200000Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11330000060800000Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2082
Count of miRNA genes:690
Interacting mature miRNAs:850
Transcripts:ENSMUST00000055931, ENSMUST00000109996
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000055931   ⟹   ENSMUSP00000057346
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,845,240 - 3,851,296 (+)Ensembl
GRCm38.p6 Ensembl113,895,240 - 3,901,296 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109996   ⟹   ENSMUSP00000105624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,845,240 - 3,849,353 (+)Ensembl
GRCm38.p6 Ensembl113,895,240 - 3,899,353 (+)Ensembl
RefSeq Acc Id: NM_173745   ⟹   NP_776106
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,845,240 - 3,851,296 (+)NCBI
GRCm38113,895,240 - 3,901,296 (+)NCBI
MGSCv37113,795,243 - 3,801,299 (+)RGD
Celera114,388,963 - 4,395,825 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514873   ⟹   XP_006514936
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,844,940 - 3,851,299 (+)NCBI
GRCm38113,894,935 - 3,901,299 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_776106   ⟸   NM_173745
- UniProtKB: Q8VE01 (UniProtKB/Swiss-Prot),   Q8BWD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514936   ⟸   XM_006514873
- Peptide Label: isoform X1
- UniProtKB: Q8VE01 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105624   ⟸   ENSMUST00000109996
RefSeq Acc Id: ENSMUSP00000057346   ⟸   ENSMUST00000055931
Promoters
RGD ID:6820178
Promoter ID:MM_KWN:6196
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000109996,   NM_026150,   NM_173745
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,794,801 - 3,795,301 (-)MPROMDB
RGD ID:8673756
Promoter ID:EPDNEW_M14909
Type:initiation region
Name:Dusp18_1
Description:Mus musculus dual specificity phosphatase 18 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,895,285 - 3,895,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922469 AgrOrtholog
Ensembl Genes ENSMUSG00000047205 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000057346 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105624 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000109996 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Atypical_DUSP_famB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:75219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1922469 ENTREZGENE
NCBI Gene 75219 ENTREZGENE
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp18 PhenoGen
PRINTS ADSPHPHTASEB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DUS18_MOUSE UniProtKB/Swiss-Prot
  Q8BWD7 ENTREZGENE, UniProtKB/TrEMBL
  Q8VE01 ENTREZGENE