NEURL1B (neuralized E3 ubiquitin protein ligase 1B) - Rat Genome Database

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Gene: NEURL1B (neuralized E3 ubiquitin protein ligase 1B) Chlorocebus sabaeus
Analyze
Symbol: NEURL1B
Name: neuralized E3 ubiquitin protein ligase 1B
RGD ID: 18437271
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); INVOLVED IN ubiquitin-dependent endocytosis (inferred); ASSOCIATED WITH atrial heart septal defect 7 (ortholog); Atrial Septal Defect with Atrioventricular Conduction Defects (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase NEURL1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,805,376 - 74,855,476 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,805,572 - 74,850,789 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,758,856 - 3,808,954 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEURL1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,805,376 - 74,855,476 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,805,572 - 74,850,789 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,758,856 - 3,808,954 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NEURL1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,641,263 - 172,691,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,641,263 - 172,691,540 (+)EnsemblGRCh38hg38GRCh38
GRCh375172,068,266 - 172,118,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,026,659 - 172,051,148 (+)NCBINCBI36Build 36hg18NCBI36
Celera5168,100,993 - 168,151,433 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,163,317 - 167,213,670 (+)NCBIHuRef
CHM1_15171,500,802 - 171,551,136 (+)NCBICHM1_1
T2T-CHM13v2.05173,181,429 - 173,231,748 (+)NCBIT2T-CHM13v2.0
Neurl1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,633,833 - 26,665,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,633,803 - 26,665,323 (+)EnsemblGRCm39 Ensembl
GRCm381726,414,859 - 26,446,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,414,829 - 26,446,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,551,910 - 26,583,294 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,149,664 - 26,169,395 (+)NCBIMGSCv36mm8
MGSCv361725,606,583 - 25,626,314 (+)NCBIMGSCv36mm8
Celera1726,947,469 - 26,978,761 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.18NCBI
Neurl1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,258,317 - 17,289,362 (-)NCBIGRCr8
mRatBN7.21016,754,002 - 16,785,049 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1016,757,208 - 16,785,119 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,507,817 - 21,534,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,996,410 - 21,023,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,486,310 - 16,513,110 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01017,048,251 - 17,075,139 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1017,048,251 - 17,075,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,945,337 - 16,972,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,020,612 - 17,048,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1016,410,661 - 16,437,321 (-)NCBICelera
Cytogenetic Map10q12NCBI
Neurl1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,369,490 - 25,403,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,369,440 - 25,404,308 (+)NCBIChiLan1.0ChiLan1.0
NEURL1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24167,780,067 - 167,830,808 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15165,919,624 - 165,970,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05167,994,646 - 168,045,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15174,932,924 - 174,956,840 (+)NCBIpanpan1.1PanPan1.1panPan2
NEURL1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,657,036 - 39,677,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,600,677 - 39,640,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0440,027,529 - 40,067,458 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,843,120 - 39,882,737 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0440,032,759 - 40,072,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,542,825 - 40,582,703 (-)NCBIUU_Cfam_GSD_1.0
Neurl1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,019,705 - 94,060,898 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,745,099 - 2,783,571 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,742,466 - 2,767,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEURL1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,536,573 - 51,581,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,536,564 - 51,581,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,910,012 - 55,954,132 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Neurl1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473317,343,107 - 17,381,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473317,342,993 - 17,381,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 15
Low 36 18 45
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007685   ⟹   ENSCSAP00000005853
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2374,805,572 - 74,850,789 (+)Ensembl
RefSeq Acc Id: XM_008015303   ⟹   XP_008013494
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12374,805,376 - 74,855,476 (+)NCBI
Vero_WHO_p1.0NW_0236660343,758,856 - 3,808,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038010381   ⟹   XP_037866309
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660343,758,856 - 3,808,953 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008013494 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005853
  ENSCSAP00000005853.1
Reference Protein Sequences
RefSeq Acc Id: XP_008013494   ⟸   XM_008015303
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RB64 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005853   ⟸   ENSCSAT00000007685
RefSeq Acc Id: XP_037866309   ⟸   XM_038010381
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009597 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007685.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  Neuralized UniProtKB/TrEMBL
  NHR_dom UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report csab:103244978 UniProtKB/TrEMBL
NCBI Gene NEURL1B ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEURL1B UniProtKB/TrEMBL
  PTHR12429 UniProtKB/TrEMBL
Pfam Neuralized UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE NHR UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART NEUZ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0D9RB64 ENTREZGENE, UniProtKB/TrEMBL