NEURL1B (neuralized E3 ubiquitin protein ligase 1B) - Rat Genome Database

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Gene: NEURL1B (neuralized E3 ubiquitin protein ligase 1B) Canis lupus familiaris
Analyze
Symbol: NEURL1B
Name: neuralized E3 ubiquitin protein ligase 1B
RGD ID: 12297884
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN ubiquitin-dependent endocytosis (ortholog); ASSOCIATED WITH atrial heart septal defect 7 (ortholog); Atrial Septal Defect with Atrioventricular Conduction Defects (ortholog); genetic disease (ortholog); FOUND IN early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase NEURL1B; neuralized homolog 1B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,657,036 - 39,677,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,600,677 - 39,640,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0440,027,529 - 40,067,458 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,843,120 - 39,882,737 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0440,032,759 - 40,072,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,542,825 - 40,582,703 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NEURL1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1439,657,036 - 39,677,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha439,600,677 - 39,640,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0440,027,529 - 40,067,458 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1439,843,120 - 39,882,737 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0440,032,759 - 40,072,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,542,825 - 40,582,703 (-)NCBIUU_Cfam_GSD_1.0
NEURL1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,641,263 - 172,691,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,641,263 - 172,691,540 (+)EnsemblGRCh38hg38GRCh38
GRCh375172,068,266 - 172,118,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,026,659 - 172,051,148 (+)NCBINCBI36Build 36hg18NCBI36
Celera5168,100,993 - 168,151,433 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5167,163,317 - 167,213,670 (+)NCBIHuRef
CHM1_15171,500,802 - 171,551,136 (+)NCBICHM1_1
T2T-CHM13v2.05173,181,429 - 173,231,748 (+)NCBIT2T-CHM13v2.0
Neurl1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,633,833 - 26,665,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,633,803 - 26,665,323 (+)EnsemblGRCm39 Ensembl
GRCm381726,414,859 - 26,446,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,414,829 - 26,446,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,551,910 - 26,583,294 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,149,664 - 26,169,395 (+)NCBIMGSCv36mm8
MGSCv361725,606,583 - 25,626,314 (+)NCBIMGSCv36mm8
Celera1726,947,469 - 26,978,761 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.18NCBI
Neurl1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,258,317 - 17,289,362 (-)NCBIGRCr8
mRatBN7.21016,754,002 - 16,785,049 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1016,757,208 - 16,785,119 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,507,817 - 21,534,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,996,410 - 21,023,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,486,310 - 16,513,110 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01017,048,251 - 17,075,139 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1017,048,251 - 17,075,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,945,337 - 16,972,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,020,612 - 17,048,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1016,410,661 - 16,437,321 (-)NCBICelera
Cytogenetic Map10q12NCBI
Neurl1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540825,369,490 - 25,403,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540825,369,440 - 25,404,308 (+)NCBIChiLan1.0ChiLan1.0
NEURL1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24167,780,067 - 167,830,808 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15165,919,624 - 165,970,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05167,994,646 - 168,045,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15174,932,924 - 174,956,840 (+)NCBIpanpan1.1PanPan1.1panPan2
Neurl1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,019,705 - 94,060,898 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366092,745,099 - 2,783,571 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366092,742,466 - 2,767,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEURL1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1651,536,573 - 51,581,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11651,536,564 - 51,581,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21655,910,012 - 55,954,132 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEURL1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,805,376 - 74,855,476 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2374,805,572 - 74,850,789 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660343,758,856 - 3,808,954 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neurl1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473317,343,107 - 17,381,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473317,342,993 - 17,381,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NEURL1B
163 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026634   ⟹   ENSCAFP00000024740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl439,661,213 - 39,696,336 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000066237   ⟹   ENSCAFP00000050093
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000072223   ⟹   ENSCAFP00000057188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000090505   ⟹   ENSCAFP00000044926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl439,660,576 - 39,696,336 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845001738   ⟹   ENSCAFP00845001374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845001752   ⟹   ENSCAFP00845001383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845001758   ⟹   ENSCAFP00845001388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl440,029,453 - 40,067,344 (-)Ensembl
RefSeq Acc Id: XM_022417991   ⟹   XP_022273699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1439,657,036 - 39,677,249 (-)NCBI
Dog10K_Boxer_Tasha439,600,677 - 39,640,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038473666   ⟹   XP_038329594
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1439,843,120 - 39,882,737 (-)NCBI
RefSeq Acc Id: XM_038473667   ⟹   XP_038329595
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1439,843,120 - 39,857,246 (-)NCBI
RefSeq Acc Id: XM_038494871   ⟹   XP_038350799
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha439,600,677 - 39,614,825 (-)NCBI
RefSeq Acc Id: XM_038534747   ⟹   XP_038390675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0440,542,825 - 40,582,703 (-)NCBI
RefSeq Acc Id: XM_038534748   ⟹   XP_038390676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0440,542,825 - 40,556,983 (-)NCBI
RefSeq Acc Id: XM_038599047   ⟹   XP_038454975
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0440,032,759 - 40,072,351 (-)NCBI
RefSeq Acc Id: XM_038599048   ⟹   XP_038454976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0440,032,759 - 40,046,858 (-)NCBI
RefSeq Acc Id: XM_038663349   ⟹   XP_038519277
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0440,027,529 - 40,067,458 (-)NCBI
RefSeq Acc Id: XM_038663350   ⟹   XP_038519278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0440,027,529 - 40,041,712 (-)NCBI
RefSeq Acc Id: XP_022273699   ⟸   XM_022417991
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LW32 (UniProtKB/TrEMBL),   A0A8I3RR77 (UniProtKB/TrEMBL),   A0A8C0KDR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000050093   ⟸   ENSCAFT00000066237
Ensembl Acc Id: ENSCAFP00000057188   ⟸   ENSCAFT00000072223
Ensembl Acc Id: ENSCAFP00000044926   ⟸   ENSCAFT00000090505
Ensembl Acc Id: ENSCAFP00000024740   ⟸   ENSCAFT00000026634
RefSeq Acc Id: XP_038329594   ⟸   XM_038473666
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038329595   ⟸   XM_038473667
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038454975   ⟸   XM_038599047
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038454976   ⟸   XM_038599048
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038519277   ⟸   XM_038663349
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LW32 (UniProtKB/TrEMBL),   A0A8I3RR77 (UniProtKB/TrEMBL),   A0A8C0KDR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519278   ⟸   XM_038663350
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM86 (UniProtKB/TrEMBL),   A0A8I3MJC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038350799   ⟸   XM_038494871
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM86 (UniProtKB/TrEMBL),   A0A8I3MJC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390675   ⟸   XM_038534747
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KDR3 (UniProtKB/TrEMBL),   A0A8C0LW32 (UniProtKB/TrEMBL),   A0A8I3RR77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390676   ⟸   XM_038534748
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PM86 (UniProtKB/TrEMBL),   A0A8I3MJC7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845001374   ⟸   ENSCAFT00845001738
Ensembl Acc Id: ENSCAFP00845001383   ⟸   ENSCAFT00845001752
Ensembl Acc Id: ENSCAFP00845001388   ⟸   ENSCAFT00845001758
Protein Domains
NHR   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016822 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001613 UniProtKB/TrEMBL
  ENSCAFG00040000351 UniProtKB/TrEMBL
  ENSCAFG00845000993 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000090505.2 UniProtKB/TrEMBL
  ENSCAFT00030002895.1 UniProtKB/TrEMBL
  ENSCAFT00030002903.1 UniProtKB/TrEMBL
  ENSCAFT00030002906.1 UniProtKB/TrEMBL
  ENSCAFT00040000593.1 UniProtKB/TrEMBL
  ENSCAFT00040000603.1 UniProtKB/TrEMBL
  ENSCAFT00040000613.1 UniProtKB/TrEMBL
  ENSCAFT00845001738 ENTREZGENE
  ENSCAFT00845001738.1 UniProtKB/TrEMBL
  ENSCAFT00845001752 ENTREZGENE
  ENSCAFT00845001752.1 UniProtKB/TrEMBL
  ENSCAFT00845001758.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  Neuralized UniProtKB/TrEMBL
  NHR_dom UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene NEURL1B ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEURL1B UniProtKB/TrEMBL
  PTHR12429 UniProtKB/TrEMBL
Pfam Neuralized UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE NHR UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART NEUZ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8C0KDR3 ENTREZGENE
  A0A8C0LW32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LZS8_CANLF UniProtKB/TrEMBL
  A0A8C0PM86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR79_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49893 ENTREZGENE