ATXN2 (ataxin 2) - Rat Genome Database

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Gene: ATXN2 (ataxin 2) Chlorocebus sabaeus
Analyze
Symbol: ATXN2
Name: ataxin 2
RGD ID: 18435218
Description: ENCODES a protein that exhibits DNA binding domain binding (ortholog); epidermal growth factor receptor binding (ortholog); INVOLVED IN cerebellar Purkinje cell differentiation (ortholog); homeostasis of number of cells (ortholog); negative regulation of multicellular organism growth (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ataxin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,704,532 - 106,860,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,705,127 - 106,859,337 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,238,814 - 138,393,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATXN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,704,532 - 106,860,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,705,127 - 106,859,337 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,238,814 - 138,393,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ATXN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,452,214 - 111,599,673 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,443,485 - 111,599,676 (-)EnsemblGRCh38hg38GRCh38
GRCh3712111,890,018 - 112,037,477 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,374,401 - 110,521,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412110,352,737 - 110,500,200NCBI
Celera12111,516,452 - 111,663,853 (-)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12108,904,559 - 109,051,670 (-)NCBIHuRef
CHM1_112111,857,982 - 112,005,420 (-)NCBICHM1_1
T2T-CHM13v2.012111,432,772 - 111,576,594 (-)NCBIT2T-CHM13v2.0
Atxn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,849,794 - 121,954,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,849,400 - 121,954,556 (+)EnsemblGRCm39 Ensembl
GRCm385121,711,609 - 121,814,950 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,711,337 - 121,816,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv375122,161,618 - 122,264,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,972,226 - 122,075,325 (+)NCBIMGSCv36mm8
Celera5118,835,912 - 118,905,112 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.93NCBI
Atxn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,413,657 - 40,509,895 (-)NCBIGRCr8
mRatBN7.21234,754,132 - 34,851,175 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,754,137 - 34,851,479 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01240,264,601 - 40,335,637 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,266,662 - 40,332,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,137,228 - 42,206,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,962,308 - 36,009,114 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,822,590 - 35,875,779 (-)NCBI
Celera1236,417,282 - 36,487,757 (-)NCBICelera
Cytogenetic Map12q16NCBI
Atxn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,101,917 - 8,216,219 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,101,410 - 8,187,815 (-)NCBIChiLan1.0ChiLan1.0
ATXN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,518,592 - 119,667,397 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,514,982 - 119,663,635 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,024,620 - 109,174,135 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,419,337 - 112,565,096 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,419,337 - 112,566,360 (-)Ensemblpanpan1.1panPan2
ATXN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,073,667 - 9,188,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,073,809 - 9,188,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,236,242 - 9,351,196 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,333,114 - 9,448,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,333,120 - 9,448,072 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,289,083 - 9,404,017 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,351,063 - 9,466,629 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,304,823 - 9,419,816 (-)NCBIUU_Cfam_GSD_1.0
Atxn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,291,141 - 155,351,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,127,477 - 4,232,393 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,127,477 - 4,188,307 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATXN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,665,122 - 32,771,813 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11432,656,537 - 32,772,082 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,652,086 - 34,767,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Atxn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,590,906 - 20,727,962 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,603,319 - 20,728,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000605   ⟹   ENSCSAP00000015456
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11106,705,127 - 106,859,337 (-)Ensembl
RefSeq Acc Id: XM_008004728   ⟹   XP_008002919
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,449 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,880 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004729   ⟹   XP_008002920
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,449 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,880 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004731   ⟹   XP_008002922
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,448 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,881 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004732   ⟹   XP_008002923
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,532 - 106,860,448 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,814 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004733   ⟹   XP_008002924
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,447 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,882 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004734   ⟹   XP_008002925
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,450 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,879 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004735   ⟹   XP_008002926
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,446 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,884 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004736   ⟹   XP_008002927
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111106,704,535 - 106,860,450 (-)NCBI
Vero_WHO_p1.0NW_023666037138,238,876 - 138,393,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037996517   ⟹   XP_037852445
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037138,238,882 - 138,393,492 (+)NCBI
RefSeq Acc Id: XM_037996518   ⟹   XP_037852446
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037138,238,884 - 138,393,492 (+)NCBI
RefSeq Acc Id: XM_037996519   ⟹   XP_037852447
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037138,238,877 - 138,393,492 (+)NCBI
RefSeq Acc Id: XM_037996520   ⟹   XP_037852448
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037138,238,882 - 138,393,492 (+)NCBI
RefSeq Acc Id: XM_037996521   ⟹   XP_037852449
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037138,238,878 - 138,393,492 (+)NCBI
RefSeq Acc Id: XP_008002923   ⟸   XM_008004732
- Peptide Label: isoform X4
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002927   ⟸   XM_008004736
- Peptide Label: isoform X12
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002925   ⟸   XM_008004734
- Peptide Label: isoform X8
RefSeq Acc Id: XP_008002920   ⟸   XM_008004729
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002919   ⟸   XM_008004728
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002922   ⟸   XM_008004731
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002924   ⟸   XM_008004733
- Peptide Label: isoform X5
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002926   ⟸   XM_008004735
- Peptide Label: isoform X9
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000015456   ⟸   ENSCSAT00000000605
RefSeq Acc Id: XP_037852447   ⟸   XM_037996519
- Peptide Label: isoform X10
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037852449   ⟸   XM_037996521
- Peptide Label: isoform X13
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037852448   ⟸   XM_037996520
- Peptide Label: isoform X11
RefSeq Acc Id: XP_037852445   ⟸   XM_037996517
- Peptide Label: isoform X6
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037852446   ⟸   XM_037996518
- Peptide Label: isoform X7
- UniProtKB: A0A0D9S3L7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000605.1 UniProtKB/TrEMBL
InterPro Ataxin-2_C UniProtKB/TrEMBL
  ATXN2-like UniProtKB/TrEMBL
  IPR047575 UniProtKB/TrEMBL
  LSM_dom_sf UniProtKB/TrEMBL
  LsmAD_domain UniProtKB/TrEMBL
  SM_dom_ATX UniProtKB/TrEMBL
NCBI Gene ATXN2 ENTREZGENE
PANTHER PTHR12854 UniProtKB/TrEMBL
  PTHR12854:SF11 UniProtKB/TrEMBL
Pfam LsmAD UniProtKB/TrEMBL
  PAM2 UniProtKB/TrEMBL
  SM-ATX UniProtKB/TrEMBL
PROSITE PS52002 UniProtKB/TrEMBL
SMART LsmAD UniProtKB/TrEMBL
Superfamily-SCOP beta-sandwich domain of Sec23/24 UniProtKB/TrEMBL
  SSF50182 UniProtKB/TrEMBL
UniProt A0A0D9S3L7 ENTREZGENE, UniProtKB/TrEMBL