PLEKHM2 (pleckstrin homology and RUN domain containing M2) - Rat Genome Database

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Gene: PLEKHM2 (pleckstrin homology and RUN domain containing M2) Chlorocebus sabaeus
Analyze
Symbol: PLEKHM2
Name: pleckstrin homology and RUN domain containing M2
RGD ID: 18431038
Description: ENCODES a protein that exhibits kinesin binding (inferred); INVOLVED IN natural killer cell mediated cytotoxicity (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); dilated cardiomyopathy (ortholog); Hereditary Pancreatitis (ortholog); FOUND IN lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family M member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,569,780 - 116,612,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,570,613 - 116,612,880 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605420,103,616 - 20,149,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PLEKHM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,569,780 - 116,612,906 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,570,613 - 116,612,880 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605420,103,616 - 20,149,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PLEKHM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,681,506 - 15,734,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,684,320 - 15,734,769 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,010,815 - 16,061,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,880,613 - 15,933,851 (+)NCBINCBI36Build 36hg18NCBI36
Celera114,493,710 - 14,544,281 (+)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,530,042 - 14,580,241 (+)NCBIHuRef
CHM1_1115,809,564 - 15,859,865 (+)NCBICHM1_1
T2T-CHM13v2.0115,125,588 - 15,179,507 (+)NCBIT2T-CHM13v2.0
Plekhm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,353,043 - 141,391,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,353,045 - 141,392,210 (-)EnsemblGRCm39 Ensembl
GRCm384141,625,732 - 141,664,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,625,734 - 141,664,899 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,181,649 - 141,220,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,897,810 - 140,944,739 (-)NCBIMGSCv36mm8
Celera4143,449,113 - 143,487,570 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.64NCBI
Plekhm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85159,222,620 - 159,261,666 (-)NCBIGRCr8
mRatBN7.25153,939,582 - 153,978,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,940,262 - 153,978,689 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,625,416 - 156,663,648 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,398,694 - 158,436,930 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,387,856 - 158,426,085 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,182,556 - 160,219,770 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,182,251 - 160,219,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,897,199 - 163,934,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,527,710 - 160,565,407 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,537,310 - 160,545,504 (-)NCBI
Celera5152,296,410 - 152,333,474 (-)NCBICelera
Cytogenetic Map5q36NCBI
Plekhm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,438,595 - 2,463,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,438,595 - 2,453,120 (-)NCBIChiLan1.0ChiLan1.0
PLEKHM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21211,181,303 - 211,231,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,429,902 - 210,480,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,826,604 - 14,877,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1115,850,776 - 15,869,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,846,673 - 15,869,327 (+)Ensemblpanpan1.1panPan2
PLEKHM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,864,958 - 81,902,682 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,865,640 - 81,880,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,402,921 - 78,440,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,513,537 - 82,551,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,513,540 - 82,551,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,266,903 - 79,305,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,284,931 - 80,323,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,350,810 - 81,389,227 (-)NCBIUU_Cfam_GSD_1.0
Plekhm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,523,883 - 37,541,272 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,348,487 - 3,365,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,348,661 - 3,366,054 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,864,968 - 74,907,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,865,116 - 74,907,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,396,273 - 69,435,738 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 11 60
Low 9
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000017696   ⟹   ENSCSAP00000017169
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20116,570,613 - 116,612,880 (-)Ensembl
RefSeq Acc Id: XM_007980426   ⟹   XP_007978617
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120116,569,780 - 116,612,906 (-)NCBI
Vero_WHO_p1.0NW_02366605420,103,616 - 20,149,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037984999   ⟹   XP_037840927
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605420,103,616 - 20,149,211 (-)NCBI
RefSeq Acc Id: XM_037985000   ⟹   XP_037840928
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605420,103,616 - 20,122,526 (-)NCBI
RefSeq Acc Id: XR_005235733
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605420,103,616 - 20,149,064 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007978617 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840927 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840928 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017169.1
Reference Protein Sequences
RefSeq Acc Id: XP_007978617   ⟸   XM_007980426
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S8I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017169   ⟸   ENSCSAT00000017696
RefSeq Acc Id: XP_037840927   ⟸   XM_037984999
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S8I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840928   ⟸   XM_037985000
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S8I0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000837 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017696.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_PLEKHM2 UniProtKB/TrEMBL
NCBI Gene PLEKHM2 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
SMART RUN UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF140741 UniProtKB/TrEMBL
UniProt A0A0D9S8I0 ENTREZGENE, UniProtKB/TrEMBL