BRIP1 (BRCA1 interacting DNA helicase 1) - Rat Genome Database

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Gene: BRIP1 (BRCA1 interacting DNA helicase 1) Chlorocebus sabaeus
Analyze
Symbol: BRIP1
Name: BRCA1 interacting DNA helicase 1 (Ensembl:BRCA1 interacting helicase 1)
RGD ID: 18398418
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN cellular response to angiotensin (ortholog); cellular response to hypoxia (ortholog); cellular response to vitamin (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); Bone Metastasis (ortholog); FOUND IN replication fork (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BRCA1 interacting helicase 1; BRCA1 interacting protein C-terminal helicase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,909,226 - 33,085,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,910,693 - 33,082,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,909,226 - 33,085,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,910,693 - 33,082,587 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
BRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381761,679,139 - 61,863,528 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1761,679,139 - 61,863,559 (-)EnsemblGRCh38hg38GRCh38
GRCh371759,756,500 - 59,940,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361757,114,767 - 57,295,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341757,114,766 - 57,295,537NCBI
Celera1758,857,566 - 59,042,100 (-)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1755,122,899 - 55,306,703 (-)NCBIHuRef
CHM1_11759,821,037 - 60,005,473 (-)NCBICHM1_1
T2T-CHM13v2.01762,547,944 - 62,734,245 (-)NCBIT2T-CHM13v2.0
Brip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,948,957 - 86,092,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,948,964 - 86,092,019 (-)EnsemblGRCm39 Ensembl
GRCm381186,058,136 - 86,201,215 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,058,138 - 86,201,193 (-)EnsemblGRCm38mm10GRCm38
MGSCv371185,871,640 - 86,014,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,874,331 - 86,017,388 (-)NCBIMGSCv36mm8
Celera1195,685,510 - 95,821,501 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.61NCBI
Brip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,402,035 - 71,528,083 (-)NCBIGRCr8
mRatBN7.21070,907,266 - 71,031,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,907,371 - 71,030,324 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01073,507,009 - 73,632,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,507,100 - 73,629,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,408,318 - 73,533,317 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,313,004 - 74,436,532 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,327,690 - 74,448,583 (-)NCBI
Celera1069,829,617 - 69,953,629 (-)NCBICelera
Cytogenetic Map10q26NCBI
Brip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554512,707,793 - 2,818,592 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554512,705,834 - 2,820,610 (-)NCBIChiLan1.0ChiLan1.0
BRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,877,272 - 78,065,251 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,695,007 - 82,883,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,786,568 - 55,973,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,901,073 - 61,083,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,901,073 - 61,083,462 (-)Ensemblpanpan1.1panPan2
BRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,804,285 - 34,984,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,806,535 - 34,983,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,033,470 - 34,213,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0935,614,312 - 35,794,767 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,614,404 - 35,793,717 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,396,970 - 34,580,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,682,046 - 34,865,676 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,768,817 - 34,949,171 (+)NCBIUU_Cfam_GSD_1.0
Brip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,935,468 - 34,073,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,003,484 - 3,137,479 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,001,445 - 3,139,538 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,498,138 - 36,639,847 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,498,138 - 36,639,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,871,343 - 37,957,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Brip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248712,052,863 - 2,198,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248712,051,044 - 2,195,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003956   ⟹   ENSCSAP00000002223
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1632,910,693 - 33,082,587 (-)Ensembl
RefSeq Acc Id: XM_008011223   ⟹   XP_008009414
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11632,909,226 - 33,085,551 (-)NCBI
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993750   ⟹   XP_037849678
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660773,666,211 - 3,849,859 (-)NCBI
RefSeq Acc Id: XM_037993751   ⟹   XP_037849679
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660773,666,211 - 3,831,311 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008009414 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849678 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849679 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002223.1
RefSeq Acc Id: XP_008009414   ⟸   XM_008011223
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R0T4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002223   ⟸   ENSCSAT00000003956
RefSeq Acc Id: XP_037849678   ⟸   XM_037993750
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R0T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849679   ⟸   XM_037993751
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R0T4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005928 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003956.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ATP-dep_Helicase_C UniProtKB/TrEMBL
  DEAD_2 UniProtKB/TrEMBL
  DinG/Rad3-like UniProtKB/TrEMBL
  Helic_SF1/SF2_ATP-bd_DinG/Rad3 UniProtKB/TrEMBL
  Helicase-like_DEXD_c2 UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rad3/Chl1-like UniProtKB/TrEMBL
NCBI Gene BRIP1 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP J PROTEIN UniProtKB/TrEMBL
  PTHR11472 UniProtKB/TrEMBL
Pfam DEAD_2 UniProtKB/TrEMBL
  Helicase_C_2 UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_2 UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  DEXDc2 UniProtKB/TrEMBL
  HELICc2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9R0T4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-25 BRIP1  BRCA1 interacting DNA helicase 1  BRIP1  BRCA1 interacting helicase 1  Symbol and/or name change 5135510 APPROVED
2021-03-16 BRIP1  BRCA1 interacting helicase 1  BRIP1  BRCA1 interacting protein C-terminal helicase 1  Symbol and/or name change 5135510 APPROVED