HADH (hydroxyacyl-CoA dehydrogenase)

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Gene: HADH (hydroxyacyl-CoA dehydrogenase) Chlorocebus sabaeus

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Symbol:

HADH

Name:

hydroxyacyl-CoA dehydrogenase

RGD ID:

18390169

Description:

ENCODES a protein that exhibits 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); negative regulation of insulin secretion (ortholog); response to activity (ortholog); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; butanoate metabolic pathway; ASSOCIATED WITH 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (ortholog); Congenital Hyperinsulinism (ortholog); diabetes mellitus (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	55,919,499 - 55,965,074 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	55,919,623 - 55,964,857 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	34,546,087 - 34,591,597 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxyacyl-CoA Dehydrogenase Deficiency (ISO)

Congenital Hyperinsulinism (ISO)

diabetes mellitus (ISO)

Experimental Diabetes Mellitus (ISO)

familial hyperinsulinemic hypoglycemia 1 (ISO)

familial hyperinsulinemic hypoglycemia 4 (ISO)

genetic disease (ISO)

hyperinsulinemic hypoglycemia (ISO)

hyperinsulinism (ISO)

myocardial infarction (ISO)

obesity (ISO)

pre-malignant neoplasm (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IEA,ISO)

fatty acid metabolic process (IEA)

negative regulation of insulin secretion (ISO)

positive regulation of cold-induced thermogenesis (IEA)

regulation of insulin secretion (IEA)

response to activity (ISO)

response to hormone (ISO)

response to insulin (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cytoplasm (IEA)

mitochondrial matrix (IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

Molecular Function

3-hydroxyacyl-CoA dehydrogenase activity (IEA,ISO)

identical protein binding (IEA)

NAD+ binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

2-aminoadipic 2-oxoadipic aciduria pathway (ISO)

3-hydroxyacyl-CoA dehydrogenase deficiency pathway (ISO)

butanoate metabolic pathway (ISO)

fatty acid beta degradation pathway (ISO)

forkhead class A signaling pathway (ISO)

glutaric aciduria type I pathway (ISO)

hyperlysinemia pathway (ISO)

lysine degradation pathway (ISO)

saccharopinuria pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HADH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	55,919,499 - 55,965,074 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	55,919,623 - 55,964,857 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	34,546,087 - 34,591,597 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HADH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	107,989,889 - 108,035,171 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	107,989,714 - 108,035,241 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	108,911,045 - 108,956,327 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	109,130,389 - 109,175,780 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	106,205,689 - 106,251,144 (+)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	104,642,283 - 104,687,973 (+)	NCBI		HuRef
CHM1_1	4	108,887,327 - 108,932,780 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	111,292,223 - 111,337,508 (+)	NCBI		T2T-CHM13v2.0

Hadh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	131,027,068 - 131,065,750 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	131,027,068 - 131,065,750 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	131,233,419 - 131,272,101 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	131,233,419 - 131,272,101 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	130,936,342 - 130,974,955 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	131,222,610 - 131,261,182 (-)	NCBI		MGSCv36	mm8
Celera	3	137,754,696 - 137,793,253 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	60.86	NCBI

Hadh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	222,462,049 - 222,504,446 (-)	NCBI		GRCr8
mRatBN7.2	2	219,787,935 - 219,830,335 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	219,787,927 - 219,830,353 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	227,444,166 - 227,486,582 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	225,343,838 - 225,386,248 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	220,201,461 - 220,243,878 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	236,353,445 - 236,395,067 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	236,353,445 - 236,395,067 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	254,902,140 - 254,944,001 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	228,698,545 - 228,751,691 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	228,685,284 - 228,738,431 (-)	NCBI
Celera	2	212,044,254 - 212,086,368 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

Hadh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	1,835,034 - 1,861,407 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	1,835,034 - 1,861,410 (-)	NCBI	ChiLan1.0	ChiLan1.0

HADH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	106,088,578 - 106,133,957 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	106,383,480 - 106,428,851 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	100,495,205 - 100,540,589 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	111,067,537 - 111,112,945 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	111,067,336 - 111,113,868 (+)	Ensembl	panpan1.1		panPan2

HADH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	28,460,445 - 28,506,141 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	28,460,193 - 28,531,280 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	13,516,288 - 13,562,132 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	28,689,480 - 28,735,351 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	28,689,484 - 28,780,497 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	28,682,743 - 28,728,360 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	28,427,283 - 28,473,178 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	11,383,587 - 11,429,427 (-)	NCBI		UU_Cfam_GSD_1.0

Hadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	12,605,927 - 12,654,203 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936818	575,023 - 623,568 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936818	575,272 - 623,496 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HADH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	113,950,034 - 114,005,511 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	113,952,561 - 114,005,510 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	122,212,898 - 122,265,850 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hadh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	1,426,775 - 1,451,440 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	1,429,989 - 1,451,447 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007999475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000002004 ⟹ ENSCSAP00000000335

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	7	55,919,623 - 55,964,857 (+)	Ensembl

RefSeq Acc Id:

XM_007999475 ⟹ XP_007997666

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	7	55,919,499 - 55,965,074 (+)	NCBI
Vero_WHO_p1.0	NW_023666037	34,546,087 - 34,591,597 (+)	NCBI

Sequence:

show sequence

CCCGCTCAGCGCTGGGACTTTACGGCCCAGGCCAATGGGAGGAGCGGGCCTCAAGGCCCCGCCC
CGCCGCCTGGTGACGTCACGGTGACGCCAGGGGAGCTCGGGAGGCAGGGCCGCGTAGGTCCCCA
CCCCCAAAGGCTGGCTTTCCGCTGCTACCCGCCACGCGCATCTTGTCCGCCCGCGTCTCGTTGC
TGTCGCCCCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCATGTCCTCCT
CGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGG
GCTGATGGGCGCCGGCATCGCCCAGGTTGCTGCAGCAACTGGTCACACAGTAGTGTTGGTAGAC
CAGACAGAGGACATTCTGGCAAAATCCAAAAAGGGAATTGAGGAAAGCCTTAGGAAAGTGGCAA
AGAAGAAGTTTGCAGAAAACCCTAAGGCTGGCGGTGAATTTGTGGAGAAGACCTTGAGCAGCAT
AGCGACCAGCACGGATGCAGCCTCTGTTGTCCACAGCACAGACTTGGTGGTGGAAGCCATCGTG
GAGAATCTGAAGGTGAAAAACGAGCTCTTCAAAAGGCTGGACAAGTTTGCTGCTGAACATACAA
TCTTTGCCAGCAACACTTCCTCCTTGCAGATTACAAGCATAGCTAATGCCACCACCAGACAAGA
CCGATTCGCTGGCCTCCATTTCTTCAACCCAGTGCCCCTGATGAAACTTGTGGAGGTCATTAAA
ACACCAATGACCAGCCAGAAGACATTTGAATCTTTGGTAGACTTTAGCAAAGCCCTGGGAAAGC
ATCCTGTTGCTTGCAAGGACACTCCTGGGTTTATTGTGAACCGCCTCCTGGTTCCATACCTCAT
GGAAGCAATCAGGCTGTATGAACGAGGTGATGCATCCAAAGAAGACATTGACACTGCTATGAAA
TTAGGAGCCGGTTACCCCATGGGCCCATTTGAGCTTCTAGATTATGTCGGACTAGATACTACAA
AGTTCATCGTGGATGGGTGGCATGAAATAGATGTGAAGAACCCATTACATCAGCCCAGCCCATT
CTTGAATAAGCTGGTAGCAGAGAACAAGTTCGGCAAGAAGACTGGAGAAGGATTTTACAAATAC
AAATGATGTGCAGCTTCTCCAGCTCTGAGAAGAACCCCTGAGAGCACTTTCCAGCCAGTGCCCC
GAGTGCCTGTGGGAATGCTCTTTGTTCTGACATTCTCTCACACAGCACAGTCTAATCAATGTGC
ATTTTGATTGTAATCTATCTGAAGTGATTATTACACCAGTTACAGCAGTAATAGATTCTCCATT
AAGAACTAATTCCCTTTTTTAGTCTGTTCACTTCTGTGTATTTTCTAAACAGCTTTATACCCTT
GGTGCCTTGGAGCAAACTTTTTTTTTTGAACCTTGTCATTTTTATGAAGAATTGCCTGGATTCG
TTCTCTCATCAAGGGAAAAGTACTTCCTCCGAGAGTGCGAGTGCACCATGCCCACTGTTGCTGC
ATGCGAGAGTGACAAGCCAATGGCACGATGTGGTATGTCTGTGAAGCACTGCAGCGAGCAGCAC
CTGGATCTTGCCTTTATAAGAACATTTTACTGCCTGCAGCTTTGAGTCTTGCCCTACATTCTGG
GCACGACATAAGATGTGTCTTTATTCAGTTCATCATGAAGATGCTGCTGCTGGATGGGTCGGCA
TATCTCTGTGTGCATGGTTTGCAGGAGGTCAGTTTTCATGTCGGTCAGTTCCACAGATCTGAAT
GATTACTGTCTGTCTGTGTCTTTTTTCCATGAGAAATCGCTGTTGCAAATTGCCTATAAATTGA
CTCTACTAAAATACAATGTTTTCGTCTGAAAATTTGAATTGAAAAAGAAATGTATAATATAAAA
TTGTAATACACTCAAACGTCTATAAAAGTAAAAAGTTGATAATTTAGCAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007997666	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000335
	ENSCSAP00000000335.1

RefSeq Acc Id:	XP_007997666 ⟸ XM_007999475
- UniProtKB:	A0A0D9QVE6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000000335 ⟸ ENSCSAT00000002004

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000003972	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002004.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	3-OHacyl-CoA_DH	UniProtKB/TrEMBL
	3-OHacyl-CoA_DH_CS	UniProtKB/TrEMBL
	3-OHacyl-CoA_DH_NAD-bd	UniProtKB/TrEMBL
	3HC_DH_C	UniProtKB/TrEMBL
	6-PGluconate_DH-like_C_sf	UniProtKB/TrEMBL
	6PGD_dom2	UniProtKB/TrEMBL
	Mito_3-hydroxyacyl-CoA_DH	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103236085	UniProtKB/TrEMBL
NCBI Gene	HADH	ENTREZGENE
PANTHER	HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR43561	UniProtKB/TrEMBL
Pfam	3HCDH	UniProtKB/TrEMBL
	3HCDH_N	UniProtKB/TrEMBL
PIRSF	HCDH	UniProtKB/TrEMBL
PROSITE	3HCDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9QVE6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)