PLEKHF1 (pleckstrin homology and FYVE domain containing 1) - Rat Genome Database

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Gene: PLEKHF1 (pleckstrin homology and FYVE domain containing 1) Chlorocebus sabaeus
Analyze
Symbol: PLEKHF1
Name: pleckstrin homology and FYVE domain containing 1
RGD ID: 18348008
Description: ENCODES a protein that exhibits metal ion binding (inferred); phosphatidylinositol binding (inferred); phosphatidylinositol-3-phosphate binding (inferred); INVOLVED IN endosome organization (inferred); endosome to lysosome transport (inferred); positive regulation of autophagy (inferred); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN early endosome (inferred); endosome (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pleckstrin homology domain-containing family F member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1624,732,774 - 24,743,636 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl624,742,024 - 24,742,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660732,264,800 - 2,275,582 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
early endosome  (IEA)
endosome  (IEA)
lysosome  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLEKHF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1624,732,774 - 24,743,636 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl624,742,024 - 24,742,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660732,264,800 - 2,275,582 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PLEKHF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381929,665,461 - 29,675,477 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1929,665,459 - 29,675,477 (+)EnsemblGRCh38hg38GRCh38
GRCh371930,156,368 - 30,166,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361934,848,167 - 34,858,224 (+)NCBINCBI36Build 36hg18NCBI36
Build 341934,847,802 - 34,858,204NCBI
Celera1926,854,527 - 26,864,585 (+)NCBICelera
Cytogenetic Map19q12NCBI
HuRef1926,668,787 - 26,678,845 (+)NCBIHuRef
CHM1_11930,157,659 - 30,167,716 (+)NCBICHM1_1
T2T-CHM13v2.01932,191,180 - 32,201,225 (+)NCBIT2T-CHM13v2.0
Plekhf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39737,920,078 - 37,927,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl737,916,396 - 37,927,440 (-)EnsemblGRCm39 Ensembl
GRCm38738,220,654 - 38,227,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl738,216,972 - 38,228,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv37739,005,673 - 39,013,013 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36737,929,761 - 37,937,047 (-)NCBIMGSCv36mm8
Celera733,384,111 - 33,391,399 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map725.36NCBI
Plekhf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81100,045,340 - 100,046,817 (-)NCBIGRCr8
mRatBN7.2190,908,304 - 90,915,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl190,904,742 - 90,915,820 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx196,304,107 - 96,305,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01104,769,821 - 104,771,297 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0198,062,634 - 98,064,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0194,609,041 - 94,616,565 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl194,609,377 - 94,610,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0195,700,153 - 95,707,361 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4190,697,260 - 90,698,737 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1190,775,372 - 90,776,840 (-)NCBI
Celera185,240,535 - 85,242,012 (-)NCBICelera
Cytogenetic Map1q21NCBI
Plekhf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554687,934,024 - 7,943,499 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554687,934,024 - 7,943,499 (-)NCBIChiLan1.0ChiLan1.0
PLEKHF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22035,646,442 - 35,656,852 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11937,643,651 - 37,653,763 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01926,593,833 - 26,604,514 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11935,354,315 - 35,364,366 (+)NCBIpanpan1.1PanPan1.1panPan2
PLEKHF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,776,122 - 121,802,881 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,781,181 - 121,782,578 (-)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,781,181 - 121,782,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01122,402,959 - 122,431,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,409,980 - 122,411,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,982,589 - 122,011,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,595,581 - 121,618,885 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,654,118 - 122,682,943 (-)NCBIUU_Cfam_GSD_1.0
Plekhf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093495,976,223 - 5,987,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365705,658,052 - 5,666,358 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365705,658,052 - 5,666,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl639,786,199 - 39,797,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1639,786,201 - 39,797,578 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2635,145,695 - 35,157,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Plekhf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247944,843,635 - 4,852,346 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247944,843,342 - 4,852,346 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000018598   ⟹   ENSCSAP00000018047
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl624,742,024 - 24,742,863 (+)Ensembl
RefSeq Acc Id: XM_007996129   ⟹   XP_007994320
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1624,732,774 - 24,743,636 (+)NCBI
Vero_WHO_p1.0NW_0236660732,264,800 - 2,275,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996130   ⟹   XP_007994321
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1624,738,076 - 24,743,625 (+)NCBI
Vero_WHO_p1.0NW_0236660732,270,005 - 2,275,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007996132   ⟹   XP_007994323
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1624,733,460 - 24,743,625 (+)NCBI
Vero_WHO_p1.0NW_0236660732,265,291 - 2,275,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037991301   ⟹   XP_037847229
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660732,265,177 - 2,275,582 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007994320 (Get FASTA)   NCBI Sequence Viewer  
  XP_007994321 (Get FASTA)   NCBI Sequence Viewer  
  XP_007994323 (Get FASTA)   NCBI Sequence Viewer  
  XP_037847229 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000018047.1
RefSeq Acc Id: XP_007994320   ⟸   XM_007996129
- Peptide Label: isoform X2
- UniProtKB: A0A0D9SB08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994323   ⟸   XM_007996132
- Peptide Label: isoform X2
- UniProtKB: A0A0D9SB08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007994321   ⟸   XM_007996130
- Peptide Label: isoform X2
- UniProtKB: A0A0D9SB08 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000018047   ⟸   ENSCSAT00000018598
RefSeq Acc Id: XP_037847229   ⟸   XM_037991301
- Peptide Label: isoform X1
- UniProtKB: A0A0D9SB08 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018598.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_domain-containing_F UniProtKB/TrEMBL
  PH_Phafin UniProtKB/TrEMBL
  PKHF1_FYVE UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene PLEKHF1 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0D9SB08 ENTREZGENE, UniProtKB/TrEMBL