DDAH2 (DDAH family member 2, ADMA-independent) - Rat Genome Database

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Gene: DDAH2 (DDAH family member 2, ADMA-independent) Chlorocebus sabaeus
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Symbol: DDAH2
Name: DDAH family member 2, ADMA-independent
RGD ID: 18340896
Description: ENCODES a protein that exhibits dimethylargininase activity (ortholog); INVOLVED IN citrulline metabolic process (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); pre-eclampsia (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dimethylarginine dimethylaminohydrolase 2; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,292,674 - 40,295,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,292,707 - 40,295,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,640,050 - 31,643,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DDAH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,292,674 - 40,295,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,292,707 - 40,295,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,640,050 - 31,643,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DDAH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,727,040 - 31,730,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,727,038 - 31,730,617 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,694,817 - 31,698,040 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,802,796 - 31,806,018 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,802,796 - 31,806,018NCBI
Celera633,293,042 - 33,296,264 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,481,041 - 31,484,263 (-)NCBIHuRef
CHM1_1631,696,934 - 31,700,156 (-)NCBICHM1_1
T2T-CHM13v2.0631,580,073 - 31,583,296 (-)NCBIT2T-CHM13v2.0
Ddah2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,278,011 - 35,281,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,278,011 - 35,281,071 (+)EnsemblGRCm39 Ensembl
GRCm381735,059,035 - 35,062,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,059,035 - 35,062,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,195,980 - 35,199,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,667,157 - 34,670,151 (+)NCBIMGSCv36mm8
Celera1738,155,720 - 38,158,784 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
Ddah2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,766,115 - 3,769,161 (-)NCBIGRCr8
mRatBN7.2203,761,460 - 3,764,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,761,465 - 3,764,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,460,950 - 4,463,996 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,823,004 - 3,826,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,360,895 - 4,363,941 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,049,260 - 5,052,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,049,496 - 5,052,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,122,457 - 7,125,503 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,829,767 - 3,836,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,829,994 - 3,831,997 (-)NCBI
Celera204,261,560 - 4,264,603 (+)NCBICelera
Cytogenetic Map20p12NCBI
Ddah2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437260,969 - 269,660 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437265,727 - 269,016 (-)NCBIChiLan1.0ChiLan1.0
DDAH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,204,269 - 46,207,547 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,165,770 - 42,169,008 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,388,401 - 31,391,637 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,277,102 - 32,280,336 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,277,102 - 32,280,338 (-)Ensemblpanpan1.1panPan2
DDAH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,206,180 - 1,209,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,206,309 - 1,208,389 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,342,719 - 1,346,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,351,545 - 1,354,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,351,552 - 1,354,808 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,210,814 - 1,214,096 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,278,042 - 1,281,342 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,345,682 - 1,348,984 (-)NCBIUU_Cfam_GSD_1.0
Ddah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,753,903 - 35,757,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,804,455 - 1,807,183 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,803,711 - 1,807,441 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDAH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,838,993 - 23,842,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,838,993 - 23,842,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Ddah2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,482,114 - 24,489,911 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,482,818 - 24,486,146 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DDAH2
23 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000006737   ⟹   ENSCSAP00000004935
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1740,292,707 - 40,295,712 (+)Ensembl
RefSeq Acc Id: XM_007973106   ⟹   XP_007971297
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,292,674 - 40,295,917 (+)NCBI
Vero_WHO_p1.0NW_02366604431,640,050 - 31,643,282 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007973108   ⟹   XP_007971299
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,292,994 - 40,295,917 (+)NCBI
Vero_WHO_p1.0NW_02366604431,640,050 - 31,642,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007973109   ⟹   XP_007971300
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,293,594 - 40,295,709 (+)NCBI
Vero_WHO_p1.0NW_02366604431,640,050 - 31,643,271 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038005917   ⟹   XP_037861845
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604431,640,050 - 31,642,939 (-)NCBI
RefSeq Acc Id: XM_038005918   ⟹   XP_037861846
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604431,640,050 - 31,643,297 (-)NCBI
RefSeq Acc Id: XM_038005919   ⟹   XP_037861847
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604431,640,050 - 31,642,939 (-)NCBI
RefSeq Acc Id: XP_007971297   ⟸   XM_007973106
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8J6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007971299   ⟸   XM_007973108
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8J6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007971300   ⟸   XM_007973109
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000004935   ⟸   ENSCSAT00000006737
RefSeq Acc Id: XP_037861846   ⟸   XM_038005918
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8J6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037861847   ⟸   XM_038005919
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8J6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037861845   ⟸   XM_038005917
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R8J6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008675 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006737.1 UniProtKB/TrEMBL
InterPro DDAH UniProtKB/TrEMBL
KEGG Report csab:103221752 UniProtKB/TrEMBL
NCBI Gene DDAH2 ENTREZGENE
PANTHER PTHR12737 UniProtKB/TrEMBL
  PTHR12737:SF16 UniProtKB/TrEMBL
Superfamily-SCOP Pentein UniProtKB/TrEMBL
UniProt A0A0D9R8J6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-25 DDAH2  DDAH family member 2, ADMA-independent  DDAH2  dimethylarginine dimethylaminohydrolase 2  Symbol and/or name change 5135510 APPROVED