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Gene: Dusp13a (dual specificity phosphatase 13a) Mus musculus

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Symbol:

Dusp13a

Name:

dual specificity phosphatase 13a

RGD ID:

163705727

MGI Page

MGI

Description:

Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

dual specificity protein phosphatase 13; dual specificity protein phosphatase 13 isoform A; dual specificity protein phosphatase 13A; Dusp13; muscle-restricted DSP; uncharacterized LOC128932648

RGD Orthologs

Human

Rat

Bonobo

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	21,796,386 - 21,798,662 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	21,783,463 - 21,801,249 (-)	Ensembl		GRCm39 Ensembl

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dusp13a	Mouse	alpha-Zearalanol	multiple interactions	ISO	RGD:163748611	6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of DUSP13A mRNA	CTD	PMID:35163327
Dusp13a	Mouse	perfluorooctanoic acid	multiple interactions	ISO	RGD:163748611	6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of DUSP13A mRNA	CTD	PMID:35163327

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dusp13a	Mouse	chromatin remodeling	involved_in	IEA	GO:0140791\|GO:0140793	2290270		GOC	GO_REF:0000108
Dusp13a	Mouse	dephosphorylation	involved_in	ISO	RGD:158012654	9068941	PMID:24531476	UniProt	PMID:24531476
Dusp13a	Mouse	regulation of transcription by RNA polymerase II	involved_in	IEA	GO:0180004	2290270		GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dusp13a	Mouse	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	2290270		UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dusp13a	Mouse	calmodulin-dependent protein phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	histone H2AXS140 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	histone H2AXY142 phosphatase activity	enables	IEA	EC:3.1.3.48	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	MAP kinase serine/threonine phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	myosin phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	non-membrane spanning protein tyrosine phosphatase activity	enables	IEA	EC:3.1.3.48	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	phosphatase activity	enables	ISO	RGD:158012654	9068941	PMID:24531476	UniProt	PMID:24531476
Dusp13a	Mouse	protein tyrosine phosphatase activity, metal-dependent	enables	IEA	EC:3.1.3.48	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003
Dusp13a	Mouse	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	enables	IEA	EC:3.1.3.16	2290270		UniProt	GO_REF:0000003

PMID:15252030	PMID:38975693

Dusp13a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	21,796,386 - 21,798,662 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	21,783,463 - 21,801,249 (-)	Ensembl		GRCm39 Ensembl

DUSP13A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	75,105,669 - 75,109,157 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	75,094,434 - 75,109,221 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	76,865,427 - 76,868,915 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	10	q22.2	NCBI
T2T-CHM13v2.0	10	75,979,167 - 75,982,656 (-)	NCBI		T2T-CHM13v2.0

Dusp13a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	2,609,091 - 2,611,707 (+)	NCBI		GRCr8
mRatBN7.2	15	2,559,763 - 2,562,379 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	2,533,547 - 2,575,539 (+)	Ensembl		mRatBN7.2 Ensembl
Cytogenetic Map	15	p16	NCBI

DUSP13A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	87,266,976 - 87,271,205 (-)	NCBI		NHGRI_mPanPan1

Variants in Dusp13a
104 total Variants

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357589	Kdnw2_m	kidney weight 2 (mouse)			Not determined		14	20887473	121269804	Mouse
27226748	Femd8_m	femur midshaft diameter 8, 10 week (mouse)					14	13769273	46737457	Mouse
1357527	Epfpq1_m	epididymal fat percentage QTL 1 (mouse)			Not determined		14	21062450	71885801	Mouse
11532711	Sluc40_m	susceptibility to lung cancer 40 (mouse)					14	1	27379943	Mouse
4141265	Appd2_m	APP associated premature death 2 (mouse)			Not determined		14	5945552	30114862	Mouse
1301372	Sluc13_m	susceptibility to lung cancer 13 (mouse)			Not determined		14	18827604	52827726	Mouse
4141550	Dbm3_m	diabetes modifier 3 (mouse)			Not determined			5143473	39143596	Mouse
1300544	Hypn_m	hyperinsulinemia (mouse)			Not determined		14	15160616	49160765	Mouse
1301991	Wta3_m	weight adult 3 (mouse)			Not determined		14	3887473	37887650	Mouse
4141864	Mrdq4_m	modifier of retinal degeneration QTL 4 (mouse)			Not determined			9923245	48765082	Mouse
1300779	Dyscalc4_m	dystrophic cardiac calcinosis 4 (mouse)			Not determined		14	12212871	46213007	Mouse
10412071	Ssen3_m	suseptibility to Sendai virus 3 (mouse)			Not determined		14	1	26987934	Mouse
27226752	Femd4_m	femur midshaft diameter 4, 5 week (mouse)					14	13769273	47237457	Mouse

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001007268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC151533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY674052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001007268 ⟹ NP_001007269

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	14	21,796,386 - 21,798,662 (-)	NCBI

Sequence:

show sequence

GCAGGCAGAGGGGTAGGCAGGCTGGCCCATGGCTGATGCCTCCATCCCAAAACCTGGGGAAGAAAAAGAAGCCACACCTTGCCCCAGTATCCTGCAGCTAGAGGAGCTCCTGAGGGCCGGGAGAGCCT
CTTGTAGTAGAGTGGATGAAGTCTGGCCCAACCTTTTCATCGGAGATGCGGCCACGGCAAATAACCGATTTGAGCTGTGGAAGTTGGGGATCACCCATGTGCTGAATGCCGCCCACGGAGGACTCTAC
TGTCAGGGGGGTCCTGACTTCTACGGCAGCAGTGTGTGCTACCTGGGGATCCCAGCCCACGACCTCCCTGATTTCAATATCAGCCCCTACTTCTCCTCAGCAGCTGACTTCATCCACCGAGCCCTCAC
CGTACCTGGAGCTAAGGTGCTGGTGCACTGCGTGGTGGGTGTGAGCCGATCTGCCACACTGGTCCTGGCTTACCTCATGCTCCACCAGCAGCTGTCCTTGCAGCAGGCCATAATCACTGTGAGGGAGC
GCCGATGGATCTTCCCCAATCGTGGCTTCCTCCGACAGCTCTGCCAGCTGGACCAGCAACTTCGGGGTGCAGGTCAGAGCTAAGGAGCCAGAGCCAGTCCTTCCGCTCTGCCGCCAGGCTCTGCCAGT
TTGCTACTCTTGCCCTGGCCCTGATGGCAGCCTTAGCCCAAGTGGACGCCCAGAAGATGAAAAGGGCCCAGCGTGGCGCTCACCGTCGAACCCGCCACTCCAACAGCCTCCTCCAGCATTCCACGTGC
CCTCTCAGCCACTGTCTTCAGTTTCCACAGAAACAGCATCAGGTGTGCGGAGCCAGGCGGCTAGAATCCAGCGGCACAAGCTGTGGGTCGGAGAAGACTACAGCCCGGTCAGGATCTCCCCACAGAAT
GGACTCGCTACAGAAGCAGGAACTTCGGAGGCCAAAGATTCATGGGGCAGTCCAGGTGTCCCCCTACCAGCCACCCACACTGGCCTCTCTGCAGCGATTGCTGTGGGTCCGTCGGACTGCCACACTGA
CCCACATCAATGAGGTCTGGCCCAACCTTTTCTTGGGAGATGCGTATGCTGCCAGAGACAAGGGTCGTCTAATCCAGCTGGGCATTACCCATGTTGTGAATGTGGCTGCGGGCAAGTTCCAGGTGGAC
ACAGGTGCCAAGTTCTACCGTGGAACACCTCTGGAGTACTATGGCATTGAGGCTGATGACAACCCCTTCTTTGACCTCAGCGTCCACTTTCTGCCTGTTGCTCGTTACATCAGAGATGCCCTCAATAT
TCCCCGAAGCCGAGTGCTGGTCCACTGCGCTATGGGGGTGAGTCGCTCTGCCACAATTGTCTTGGCCTTCCTCATGATCTTCGAGAACATGACACTGGTAGATGCCATCCAGACGGTGCAGGCCCACC
GAGATATCTGTCCCAACTCAGGCTTCCTCCGACAGCTCCAGGTTCTGGACAACAGGCTGAGGCGGGAAACAGGAAGACTCTGAATTAGGGAGCACCTGAGGCCCTGACCCCTCCATCCAGCGTGGCCT
AACCTGACCTACCTGGCCCTGGGAATGGTAGCCTCTGCTGTTTCCAGAGATCCTGAGATGGCACCAGCAAGTCAGGGCTCCGCTGAGGCAGAGGCAGGGTGGGCTGGGTGGCACCCCTCAGCAAGTGG
AGTCCCCTGACACAGTACAGAAACTCTTTATACAGAAGAAATTTCAGACTGTCTCTATAATAAAAGGTTCATCATAATAAA

hide sequence


Protein RefSeqs	NP_001007269	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT79357	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000074553
	ENSMUSP00000074553.3
GenBank Protein	Q6B8I0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007269 ⟸ NM_001007268
- UniProtKB:	Q6B8I0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MADASIPKPGEEKEATPCPSILQLEELLRAGRASCSRVDEVWPNLFIGDAATANNRFELWKLGITHVLNAAHGGLYCQGGPDFYGSSVCYLGIPAHDLPDFNISPYFSSAADFIHRALTVPGAKVLVH CVVGVSRSATLVLAYLMLHQQLSLQQAIITVRERRWIFPNRGFLRQLCQLDQQLRGAGQS hide sequence

Protein Domains

Dual specificity phosphatase catalytic Tyrosine-protein phosphatase

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000121906	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000075040	ENTREZGENE
	ENSMUST00000075040.9	UniProtKB/Swiss-Prot
Gene3D-CATH	Protein tyrosine phosphatase superfamily	UniProtKB/Swiss-Prot
InterPro	Atypical_DUSP_subfamA	UniProtKB/Swiss-Prot
	Dual-sp_phosphatase_cat-dom	UniProtKB/Swiss-Prot
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot
	Tyr_Pase_AS	UniProtKB/Swiss-Prot
	Tyr_Pase_cat	UniProtKB/Swiss-Prot
	Tyr_Pase_dom	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/Swiss-Prot
KEGG Report	mmu:128932648	UniProtKB/Swiss-Prot
MGD	MGI:7470874	ENTREZGENE
NCBI Gene	Dusp13	ENTREZGENE
PANTHER	AGAP008228-PA	UniProtKB/Swiss-Prot
	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot
Pfam	DSPc	UniProtKB/Swiss-Prot
PhenoGen	Dusp13a	PhenoGen
PRINTS	ADSPHPHTASE	UniProtKB/Swiss-Prot
	ADSPHPHTASEA	UniProtKB/Swiss-Prot
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL	UniProtKB/Swiss-Prot
SMART	DSPc	UniProtKB/Swiss-Prot
	PTPc_motif	UniProtKB/Swiss-Prot
Superfamily-SCOP	(Phosphotyrosine protein) phosphatases II	UniProtKB/Swiss-Prot
UniProt	DS13A_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	V9GXG6_MOUSE	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-06-06	Dusp13a	dual specificity phosphatase 13a	Dusp13a	dual specificity phosphatase 13A	Symbol and/or name change	5135510	APPROVED
2023-04-18	Dusp13a	dual specificity phosphatase 13A	Dusp13	uncharacterized LOC128932648	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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