Crisp4 (cysteine-rich secretory protein 4) - Rat Genome Database

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Gene: Crisp4 (cysteine-rich secretory protein 4) Mus musculus
Analyze
Symbol: Crisp4
Name: cysteine-rich secretory protein 4
RGD ID: 1623883
MGI Page MGI
Description: Enables calcium channel regulator activity. Acts upstream of or within binding activity of sperm to zona pellucida and regulation of acrosome reaction. Predicted to be active in extracellular space. Orthologous to human CRISP1 (cysteine rich secretory protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230112K08Rik; cysteine-rich secretory protein 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39118,185,113 - 18,216,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl118,185,415 - 18,216,126 (-)EnsemblGRCm39 Ensembl
GRCm38118,114,889 - 18,145,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl118,115,191 - 18,145,902 (-)EnsemblGRCm38mm10GRCm38
MGSCv37118,105,272 - 18,127,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36118,100,405 - 18,122,265 (-)NCBIMGSCv36mm8
Celera118,019,226 - 18,041,066 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:15673606   PMID:16141072   PMID:16141073   PMID:16467491   PMID:21482758   PMID:21677750   PMID:21865554  
PMID:21873635   PMID:28911169   PMID:29361143   PMID:30510210   PMID:31218833   PMID:33037689   PMID:34422816  


Genomics

Comparative Map Data
Crisp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39118,185,113 - 18,216,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl118,185,415 - 18,216,126 (-)EnsemblGRCm39 Ensembl
GRCm38118,114,889 - 18,145,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl118,115,191 - 18,145,902 (-)EnsemblGRCm38mm10GRCm38
MGSCv37118,105,272 - 18,127,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36118,100,405 - 18,122,265 (-)NCBIMGSCv36mm8
Celera118,019,226 - 18,041,066 (-)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.65NCBI
CRISP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,834,257 - 49,877,096 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,834,257 - 49,877,096 (-)EnsemblGRCh38hg38GRCh38
GRCh37649,801,970 - 49,844,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,909,929 - 49,942,177 (-)NCBINCBI36Build 36hg18NCBI36
Celera651,358,053 - 51,390,301 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,532,400 - 49,575,243 (-)NCBIHuRef
CHM1_1649,804,885 - 49,847,721 (-)NCBICHM1_1
T2T-CHM13v2.0649,676,220 - 49,719,057 (-)NCBIT2T-CHM13v2.0
Crisp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8928,238,326 - 28,265,344 (-)NCBIGRCr8
mRatBN7.2920,741,775 - 20,768,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,741,777 - 20,768,796 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx929,272,264 - 29,299,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,375,604 - 34,415,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,686,420 - 32,726,441 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,356,577 - 24,383,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,356,579 - 24,383,679 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0923,218,716 - 23,245,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,975,151 - 17,002,149 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera918,378,604 - 18,405,902 (-)NCBICelera
Cytogenetic Map9q13NCBI
CRISP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2564,319,223 - 64,358,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1660,184,866 - 60,221,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,404,220 - 49,452,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,665,193 - 50,712,092 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,665,204 - 50,712,092 (-)Ensemblpanpan1.1panPan2
CRISP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,659,446 - 17,696,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,555,565 - 17,595,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01218,153,788 - 18,193,483 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01217,779,242 - 17,812,493 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01217,909,484 - 17,942,885 (-)NCBIUU_Cfam_GSD_1.0
Crisp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494653,207,268 - 53,230,604 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647610,729,610 - 10,752,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647610,729,598 - 10,753,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRISP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,883,539 - 43,911,664 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,883,536 - 43,911,877 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,275,809 - 50,303,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRISP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,539,467 - 22,581,428 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,551,309 - 22,579,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604449,798,950 - 49,845,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:185
Interacting mature miRNAs:211
Transcripts:ENSMUST00000026876, ENSMUST00000115340, ENSMUST00000115344, ENSMUST00000130669
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
4141646Fecq3_mfecundity QTL 3 (mouse)Not determined11291692026517685Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000026876   ⟹   ENSMUSP00000026876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl118,185,415 - 18,216,126 (-)Ensembl
GRCm38.p6 Ensembl118,115,191 - 18,145,902 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115340   ⟹   ENSMUSP00000110997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl118,185,428 - 18,207,275 (-)Ensembl
GRCm38.p6 Ensembl118,115,204 - 18,137,051 (-)Ensembl
Ensembl Acc Id: ENSMUST00000115344   ⟹   ENSMUSP00000111001
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl118,185,824 - 18,216,126 (-)Ensembl
GRCm38.p6 Ensembl118,115,600 - 18,145,902 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl118,185,415 - 18,216,120 (-)Ensembl
GRCm38.p6 Ensembl118,115,191 - 18,145,896 (-)Ensembl
RefSeq Acc Id: NM_001347047   ⟹   NP_001333976
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39118,185,415 - 18,216,126 (-)NCBI
GRCm38118,115,191 - 18,145,902 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001347048   ⟹   NP_001333977
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39118,185,415 - 18,216,126 (-)NCBI
GRCm38118,115,191 - 18,145,902 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006495589   ⟹   XP_006495652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39118,185,129 - 18,211,670 (-)NCBI
GRCm38118,114,905 - 18,141,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006495591   ⟹   XP_006495654
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39118,185,113 - 18,211,670 (-)NCBI
GRCm38118,114,889 - 18,141,446 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006495654   ⟸   XM_006495591
- Peptide Label: isoform X2
- UniProtKB: Q9D259 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495652   ⟸   XM_006495589
- Peptide Label: isoform X1
- UniProtKB: Q9D259 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333977   ⟸   NM_001347048
- Peptide Label: isoform 3
- UniProtKB: G5E862 (UniProtKB/TrEMBL),   Q9D259 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001333976   ⟸   NM_001347047
- Peptide Label: isoform 2
- UniProtKB: E9PVG4 (UniProtKB/TrEMBL),   Q9D259 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000026876   ⟸   ENSMUST00000026876
Ensembl Acc Id: ENSMUSP00000111001   ⟸   ENSMUST00000115344
Ensembl Acc Id: ENSMUSP00000110997   ⟸   ENSMUST00000115340
Protein Domains
ShKT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PVG4-F1-model_v2 AlphaFold E9PVG4 1-293 view protein structure

Promoters
RGD ID:6873246
Promoter ID:EPDNEW_M74
Type:initiation region
Name:Crisp4_1
Description:Mus musculus cysteine-rich secretory protein 4 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38118,145,902 - 18,145,962EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925331 AgrOrtholog
Ensembl Genes ENSMUSG00000025774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026876 ENTREZGENE
  ENSMUST00000026876.13 UniProtKB/TrEMBL
  ENSMUST00000115340.8 UniProtKB/TrEMBL
  ENSMUST00000115344 ENTREZGENE
  ENSMUST00000115344.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.740 UniProtKB/TrEMBL
  3.40.33.10 UniProtKB/TrEMBL
InterPro Allrgn_V5/Tpx1 UniProtKB/TrEMBL
  Allrgn_V5/Tpx1_CS UniProtKB/TrEMBL
  CAP_domain UniProtKB/TrEMBL
  CAP_sf UniProtKB/TrEMBL
  Crisp-like_dom UniProtKB/TrEMBL
  Cysteine_rich_secretory UniProtKB/TrEMBL
  SCP_CRISP UniProtKB/TrEMBL
  ShKT_dom UniProtKB/TrEMBL
KEGG Report mmu:78081 UniProtKB/TrEMBL
MGD MGI:1925331 ENTREZGENE
NCBI Gene 78081 ENTREZGENE
PANTHER Allrgn_V5/Tpx1 UniProtKB/TrEMBL
  CYSTEINE-RICH SECRETORY PROTEIN 1 UniProtKB/TrEMBL
Pfam CAP UniProtKB/TrEMBL
  Crisp UniProtKB/TrEMBL
PhenoGen Crisp4 PhenoGen
PRINTS V5TPXLIKE UniProtKB/TrEMBL
PROSITE CRISP_1 UniProtKB/TrEMBL
  SHKT UniProtKB/TrEMBL
SMART SCP UniProtKB/TrEMBL
Superfamily-SCOP Crisp domain-like UniProtKB/TrEMBL
  SCP-like_extracellular UniProtKB/TrEMBL
UniProt E9PVG4 ENTREZGENE, UniProtKB/TrEMBL
  G5E862 ENTREZGENE, UniProtKB/TrEMBL
  Q9D259 ENTREZGENE, UniProtKB/TrEMBL