Nlrp14 (NLR family, pyrin domain containing 14) - Rat Genome Database

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Gene: Nlrp14 (NLR family, pyrin domain containing 14) Mus musculus
Analyze
Symbol: Nlrp14
Name: NLR family, pyrin domain containing 14
RGD ID: 1623111
MGI Page MGI
Description: Predicted to enable ATP binding activity. Predicted to be involved in regulation of inflammatory response and spermatogenesis. Predicted to act upstream of or within cell differentiation. Predicted to be active in cytoplasm. Is expressed in early conceptus; gonad; and uterus. Orthologous to human NLRP14 (NLR family pyrin domain containing 14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4921520L01Rik; GC-; GC-LRR; germ cell specific leucine-rich repeat NTPase; germ-cell specific leucine rich repeat NTPase; Na; NACHT, leucine rich repeat and PYD containing 14; NACHT, LRR and PYD domains-containing protein 14; Nalp-iota; Nalp14; Nalp14l; RNI-like protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397106,712,662 - 106,797,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7106,766,197 - 106,797,309 (+)EnsemblGRCm39 Ensembl
GRCm387107,113,455 - 107,198,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7107,166,990 - 107,198,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv377114,310,504 - 114,341,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367106,958,167 - 106,989,279 (+)NCBIMGSCv36mm8
Celera7107,162,901 - 107,194,394 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map756.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11416212   PMID:12466851   PMID:12477932   PMID:15317747   PMID:15590904   PMID:16141072   PMID:16141073  
PMID:17015433   PMID:17567914   PMID:21267068   PMID:21873635   PMID:24357321   PMID:32325033   PMID:34174788   PMID:36539615   PMID:37493331   PMID:38060382  


Genomics

Comparative Map Data
Nlrp14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397106,712,662 - 106,797,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7106,766,197 - 106,797,309 (+)EnsemblGRCm39 Ensembl
GRCm387107,113,455 - 107,198,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7107,166,990 - 107,198,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv377114,310,504 - 114,341,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367106,958,167 - 106,989,279 (+)NCBIMGSCv36mm8
Celera7107,162,901 - 107,194,394 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map756.1NCBI
NLRP14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38117,020,446 - 7,090,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl117,020,479 - 7,071,526 (+)EnsemblGRCh38hg38GRCh38
GRCh37117,041,710 - 7,092,757 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,998,276 - 7,049,333 (+)NCBINCBI36Build 36hg18NCBI36
Build 34117,016,372 - 7,049,333NCBI
Celera117,160,740 - 7,211,803 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,700,195 - 6,751,227 (+)NCBIHuRef
CHM1_1117,040,627 - 7,091,687 (+)NCBICHM1_1
T2T-CHM13v2.0117,078,824 - 7,149,635 (+)NCBIT2T-CHM13v2.0
Nlrp14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81170,472,956 - 170,500,962 (+)NCBIGRCr8
mRatBN7.21161,069,141 - 161,089,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1161,061,165 - 161,089,222 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01171,305,558 - 171,340,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,306,049 - 171,340,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01178,325,007 - 178,343,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,520,792 - 164,537,945 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1158,973,913 - 159,002,277 (+)NCBICelera
Cytogenetic Map1q33NCBI
Nlrp14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,885,205 - 22,914,343 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,885,226 - 22,914,254 (+)NCBIChiLan1.0ChiLan1.0
NLRP14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v299,426,349 - 9,549,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,391,774 - 9,443,639 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0117,122,928 - 7,174,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,805,331 - 6,856,718 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,805,331 - 6,856,718 (+)Ensemblpanpan1.1panPan2
NLRP14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12130,713,700 - 30,922,332 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2130,713,351 - 30,907,113 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2130,284,577 - 30,328,235 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02131,522,062 - 31,566,213 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2131,522,374 - 31,701,331 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12130,852,579 - 30,894,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02131,015,517 - 31,059,147 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02131,310,739 - 31,354,651 (+)NCBIUU_Cfam_GSD_1.0
Nlrp14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494754,715,514 - 54,745,817 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936841341,505 - 371,728 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.192,542,538 - 2,550,430 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,013,131 - 3,026,295 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NLRP14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1157,659,342 - 57,793,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl157,752,336 - 57,786,254 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038155,503,131 - 155,539,286 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlrp14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248178,804,529 - 8,832,874 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248178,804,708 - 8,832,251 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlrp14
1203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSMUST00000084763, ENSMUST00000142623
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse

Markers in Region
Nlrp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387107,191,182 - 107,192,617UniSTSGRCm38
MGSCv377114,334,696 - 114,336,131UniSTSGRCm37
Celera7107,187,449 - 107,188,886UniSTS
Cytogenetic Map7E3UniSTS
cM Map7 UniSTS
Nlrp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7E3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000084763   ⟹   ENSMUSP00000081819
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7106,766,197 - 106,797,300 (+)Ensembl
GRCm38.p6 Ensembl7107,166,990 - 107,198,093 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142623   ⟹   ENSMUSP00000145427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7106,786,335 - 106,797,309 (+)Ensembl
GRCm38.p6 Ensembl7107,187,128 - 107,198,102 (+)Ensembl
RefSeq Acc Id: NM_001002894   ⟹   NP_001002894
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397106,766,197 - 106,797,310 (+)NCBI
GRCm387107,166,990 - 107,198,103 (+)NCBI
MGSCv377114,310,504 - 114,341,617 (+)RGD
Celera7107,162,901 - 107,194,394 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011241938   ⟹   XP_011240240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397106,712,662 - 106,797,310 (+)NCBI
GRCm387107,113,455 - 107,198,103 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001002894   ⟸   NM_001002894
- UniProtKB: B2RUL1 (UniProtKB/Swiss-Prot),   Q66X14 (UniProtKB/Swiss-Prot),   Q6B966 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240240   ⟸   XM_011241938
- Peptide Label: isoform X1
- UniProtKB: B2RUL1 (UniProtKB/Swiss-Prot),   Q66X14 (UniProtKB/Swiss-Prot),   Q6B966 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000081819   ⟸   ENSMUST00000084763
RefSeq Acc Id: ENSMUSP00000145427   ⟸   ENSMUST00000142623
Protein Domains
NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6B966-F1-model_v2 AlphaFold Q6B966 1-993 view protein structure

Promoters
RGD ID:8665151
Promoter ID:EPDNEW_M10607
Type:single initiation site
Name:Nlrp14_1
Description:Mus musculus NLR family, pyrin domain containing 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387107,166,990 - 107,167,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924108 AgrOrtholog
Ensembl Genes ENSMUSG00000016626 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000084763 ENTREZGENE
  ENSMUST00000084763.5 UniProtKB/Swiss-Prot
  ENSMUST00000142623.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot
  NLRC_HD2 UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:76858 UniProtKB/Swiss-Prot
MGD MGI:1924108 ENTREZGENE
NCBI Gene 76858 ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot
  NLRC4_HD2 UniProtKB/Swiss-Prot
  NOD2_WH UniProtKB/Swiss-Prot
PhenoGen Nlrp14 PhenoGen
PROSITE NACHT UniProtKB/Swiss-Prot
SMART LRR_RI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0N4SW95_MOUSE UniProtKB/TrEMBL
  B2RUL1 ENTREZGENE
  NAL14_MOUSE UniProtKB/Swiss-Prot
  Q66X14 ENTREZGENE
  Q6B966 ENTREZGENE
UniProt Secondary B2RUL1 UniProtKB/Swiss-Prot
  Q66X14 UniProtKB/Swiss-Prot