Ces1a (carboxylesterase 1A) - Rat Genome Database

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Gene: Ces1a (carboxylesterase 1A) Mus musculus
Analyze
No known orthologs.
Symbol: Ces1a
Name: carboxylesterase 1A
RGD ID: 1622913
MGI Page MGI
Description: Predicted to enable carboxylesterase activity and sterol ester esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in ductus deferens and testis. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 1-like; Ces1l; EG244595; Gm4976; MGC102259
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,746,842 - 93,774,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,746,842 - 93,774,820 (-)EnsemblGRCm39 Ensembl
GRCm38893,020,214 - 93,048,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,020,214 - 93,048,192 (-)EnsemblGRCm38mm10GRCm38
MGSCv37895,544,113 - 95,572,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,909,342 - 95,937,320 (-)NCBIMGSCv36mm8
Celera897,349,716 - 97,376,822 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ces1aMousebuta-1,3-diene increases expressionEXP 64804641 and 3-butadiene results in increased expression of CES1A mRNACTDPMID:29038090
Ces1aMousecalcium silicate increases expressionEXP 6480464calcium silicate results in increased expression of CES1A mRNACTDPMID:29279043
Ces1aMousegenistein increases expressionEXP 6480464Genistein results in increased expression of CES1A mRNACTDPMID:24967385
Ces1aMouseTriptolide increases expressionEXP 6480464triptolide results in increased expression of CES1A mRNACTDPMID:32835833


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ces1aMousecellular response to cholesterol involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousecellular response to low-density lipoprotein particle stimulus involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousecholesterol biosynthetic process involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousecholesterol homeostasis involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousecholesterol metabolic process involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouseepithelial cell differentiation involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouselipid catabolic process involved_inIBAPANTHER:PTN000168833 more ...2290270 GO_CentralGO_REF:0000033
Ces1aMousemedium-chain fatty acid metabolic process involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousenegative regulation of cholesterol storage involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousepositive regulation of cholesterol efflux involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousepositive regulation of cholesterol metabolic process involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouseregulation of bile acid biosynthetic process involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouseregulation of bile acid secretion involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousereverse cholesterol transport involved_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ces1aMousecytoplasm located_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouseendoplasmic reticulum located_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMouseendoplasmic reticulum is_active_inIBAPANTHER:PTN000168833 more ...2290270 GO_CentralGO_REF:0000033
Ces1aMouselipid droplet is_active_inIBAPANTHER:PTN000168833 more ...2290270 GO_CentralGO_REF:0000033
Ces1aMouselipid droplet located_inISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ces1aMousecarboxylesterase activity enablesISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119
Ces1aMousecarboxylic ester hydrolase activity enablesIBAPANTHER:PTN000168833 more ...2290270 GO_CentralGO_REF:0000033
Ces1aMousesterol ester esterase activity enablesISOUniProtKB:P231412290270 GO_CentralGO_REF:0000119

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ces1aMouseincreased cardiac output  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:20931200   PMID:21677750   PMID:21873635   PMID:24194600   PMID:36174736   PMID:38355793  



.

.
Variants in Ces1a
2523 total Variants

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:92
Interacting mature miRNAs:93
Transcripts:ENSMUST00000095211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse

1 to 10 of 30 rows
CES2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,044,918 - 93,045,068UniSTSGRCm38
MGSCv37895,568,817 - 95,568,967UniSTSGRCm37
Celera897,373,537 - 97,373,687UniSTS
Cytogenetic Map8C5UniSTS







Ensembl Acc Id: ENSMUST00000095211   ⟹   ENSMUSP00000092836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,746,842 - 93,774,820 (-)Ensembl
GRCm38.p6 Ensembl893,020,214 - 93,048,192 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209753
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl893,762,578 - 93,767,731 (-)Ensembl
GRCm38.p6 Ensembl893,035,950 - 93,041,103 (-)Ensembl
RefSeq Acc Id: NM_001013764   ⟹   NP_001013786
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,746,842 - 93,774,820 (-)NCBI
GRCm38893,020,214 - 93,048,192 (-)ENTREZGENE
MGSCv37895,544,113 - 95,572,091 (-)RGD
Celera897,349,716 - 97,376,822 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530999   ⟹   XP_006531062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,746,847 - 93,767,159 (-)NCBI
GRCm38893,020,219 - 93,040,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312820   ⟹   XP_017168309
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,746,847 - 93,767,572 (-)NCBI
GRCm38893,020,219 - 93,041,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243550   ⟹   XP_030099410
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39893,746,847 - 93,767,590 (-)NCBI
GRCm38893,020,219 - 93,041,511 (-)NCBI
Sequence:
Protein RefSeqs NP_001013786 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531062 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168309 (Get FASTA)   NCBI Sequence Viewer  
  XP_030099410 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89371 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000092836
  ENSMUSP00000092836.5
RefSeq Acc Id: NP_001013786   ⟸   NM_001013764
- Peptide Label: precursor
- UniProtKB: E9PYP1 (UniProtKB/TrEMBL),   Q5FWH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531062   ⟸   XM_006530999
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017168309   ⟸   XM_017312820
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030099410   ⟸   XM_030243550
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000092836   ⟸   ENSMUST00000095211
Carboxylesterase type B

Name Modeler Protein Id AA Range Protein Structure
AF-E9PYP1-F1-model_v2 AlphaFold E9PYP1 1-563 view protein structure



1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000071047 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095211 ENTREZGENE
  ENSMUST00000095211.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Type-B_Carboxylest/Lipase UniProtKB/TrEMBL
KEGG Report mmu:244595 UniProtKB/TrEMBL
MGD MGI:3648919 ENTREZGENE
NCBI Gene 244595 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PhenoGen Ces1a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt E9PYP1 ENTREZGENE, UniProtKB/TrEMBL
  Q5FWH4 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Ces1a  carboxylesterase 1A  Gm4976  predicted gene 4976  Symbol and/or name change 5135510 APPROVED