Ptgs2os (prostaglandin-endoperoxide synthase 2, opposite strand) - Rat Genome Database

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Gene: Ptgs2os (prostaglandin-endoperoxide synthase 2, opposite strand) Mus musculus
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Symbol: Ptgs2os
Name: prostaglandin-endoperoxide synthase 2, opposite strand
RGD ID: 1621986
MGI Page MGI
Description: Acts upstream of or within negative regulation of toll-like receptor signaling pathway and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus.
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: 7530420F21Rik
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,950,624 - 149,975,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,909,888 - 149,975,714 (-)EnsemblGRCm39 Ensembl
GRCm381150,074,873 - 150,099,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,074,873 - 150,099,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,923,791 - 151,946,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,000,493 - 150,025,425 (-)NCBIMGSCv36mm8
Celera1152,523,330 - 152,546,370 (-)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgs2osMousealdehydo-D-glucose multiple interactionsEXP 6480464fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]CTDPMID:33448797
Ptgs2osMousealdehydo-D-glucose increases expressionEXP 6480464Glucose results in increased expression of PTGS2OS mRNACTDPMID:33448797
Ptgs2osMouseD-glucose multiple interactionsEXP 6480464fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]CTDPMID:33448797
Ptgs2osMouseD-glucose increases expressionEXP 6480464Glucose results in increased expression of PTGS2OS mRNACTDPMID:33448797
Ptgs2osMousefucoxanthin multiple interactionsEXP 6480464fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]CTDPMID:33448797
Ptgs2osMouseglucose increases expressionEXP 6480464Glucose results in increased expression of PTGS2OS mRNACTDPMID:33448797
Ptgs2osMouseglucose multiple interactionsEXP 6480464fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]CTDPMID:33448797


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgs2osMousenegative regulation of toll-like receptor signaling pathway acts_upstream_of_or_withinIDA 2290270 PMID:23907535MGIPMID:23907535
Ptgs2osMousenegative regulation of toll-like receptor signaling pathway acts_upstream_of_or_withinIMP 2290270 PMID:23907535MGIPMID:23907535
Ptgs2osMousenegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIGIMGI:104819|MGI:13302942290270 PMID:23907535MGIPMID:23907535
Ptgs2osMousetoll-like receptor signaling pathway acts_upstream_ofIDA 2290270 PMID:23907535MGIPMID:23907535
Ptgs2osMousetoll-like receptor signaling pathway acts_upstream_ofIMP 2290270 PMID:23907535MGIPMID:23907535

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgs2osMousecytosol located_inIDA 2290270 PMID:23907535MGIPMID:23907535
Ptgs2osMousenucleus located_inIDA 2290270 PMID:23907535MGIPMID:23907535

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgs2osMouseprotein binding enablesIPIPR:O88569|PR:Q990202290270 PMID:23907535MGIPMID:23907535

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptgs2osMouseabnormal chemokine level  IAGP 5509061 MGIPMID:35365562
Ptgs2osMousedecreased CCL3 level  IAGP 5509061 MGIPMID:35365562
Ptgs2osMousedecreased circulating CCL3 level  IAGP 5509061 MGIPMID:35365562
Ptgs2osMousedecreased circulating interleukin-6 level  IAGP 5509061 MGIPMID:35365562
Ptgs2osMousedecreased neutrophil cell number  IAGP 5509061 MGIPMID:35365562
Ptgs2osMouseincreased interferon-beta secretion  IAGP 5509061 MGIPMID:35365562
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068   PMID:35365562  



Ptgs2os
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,950,624 - 149,975,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,909,888 - 149,975,714 (-)EnsemblGRCm39 Ensembl
GRCm381150,074,873 - 150,099,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,074,873 - 150,099,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,923,791 - 151,946,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,000,493 - 150,025,425 (-)NCBIMGSCv36mm8
Celera1152,523,330 - 152,546,370 (-)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2os
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,710,129 - 64,713,837 (-)NCBIGRCr8
mRatBN7.21362,160,002 - 62,163,710 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1364,794,458 - 64,798,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,079,255 - 66,082,977 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,340,803 - 63,344,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,347,152 - 67,350,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01372,312,292 - 72,316,000 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1362,125,361 - 62,129,069 (-)NCBICelera
Cytogenetic Map13q21NCBI

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Variants in Ptgs2os
2403 total Variants

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:141
Interacting mature miRNAs:142
Transcripts:ENSMUST00000181460, ENSMUST00000181915
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 61 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse

1 to 10 of 61 rows






Ensembl Acc Id: ENSMUST00000181460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,973,932 - 149,975,714 (-)Ensembl
GRCm38.p6 Ensembl1150,098,181 - 150,099,963 (-)Ensembl
Ensembl Acc Id: ENSMUST00000181915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,950,624 - 149,975,568 (-)Ensembl
GRCm38.p6 Ensembl1150,074,873 - 150,099,817 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,909,904 - 149,975,652 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,909,888 - 149,975,431 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,919,694 - 149,963,096 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,952,769 - 149,975,571 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,967,129 - 149,975,675 (-)Ensembl
Ensembl Acc Id: ENSMUST00000342693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,972,892 - 149,975,668 (-)Ensembl
RefSeq Acc Id: NR_015466
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391149,950,624 - 149,975,625 (-)NCBI
GRCm381150,074,873 - 150,099,874 (-)NCBI
MGSCv371151,923,791 - 151,946,896 (-)RGD
Celera1152,521,541 - 152,546,478 (-)NCBI
cM Map1 ENTREZGENE
Sequence:


Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000097028 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000181915 ENTREZGENE
MGD MGI:2443180 ENTREZGENE
NCBI Gene 320019 ENTREZGENE
PhenoGen Ptgs2os PhenoGen
RNAcentral URS000075D46F RNACentral
  URS00009BB16D RNACentral


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-01-21 Ptgs2os  prostaglandin-endoperoxide synthase 2, opposite strand  7530420F21Rik  RIKEN cDNA 7530420F21 gene  Symbol and/or name change 5135510 APPROVED